IPO7 and H1-0

Number of citations of the paper that reports this interaction (PubMedID 10228156)
63

Data Source:
HPRD (in vitro)

		IPO7	H1-0
Description		importin 7	H1.0 linker histone
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm Chromosome Golgi Apparatus Actin Cytoskeleton Nuclear Body Transcription Repressor Complex
	Molecular Function	Protein Binding GTPase Regulator Activity Small GTPase Binding Histone Binding SMAD Binding	DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosome Binding Nucleosomal DNA Binding
	Biological Process	Protein Import Into Nucleus Intracellular Protein Transport Protein Transport Innate Immune Response Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Odontoblast Differentiation	Nucleosome Assembly Chromosome Condensation Heterochromatin Formation Negative Regulation Of DNA Recombination Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways			Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Interleukin-10 levels ( 22205395)
Interacting Genes		14 interacting genes: AKTIP CEBPA H1-0 KPNB1 LIMS1 LINC01554 NOSIP PTEN RAN RNF10 RPL23A RPL5 RPS7 SRP19	20 interacting genes: APP CCNE1 CDK1 CDK2 CDK4 CDK5 FBXO7 GRB2 HPF1 IKBKG IPO5 IPO7 KPNA2 KPNB1 NEDD4L NOA1 PARP2 PRKCB RAD51B XBP1
Entrez ID		10527	3005
HPRD ID		09280	00819
Ensembl ID		ENSG00000205339	ENSG00000189060
Uniprot IDs		B3KNG9 O95373	P07305
PDB IDs			6HQ1 6LA2 6LA8 6LA9 6LAB 6N88 6N89 7COW 7DBP 7K5X 7XVL 7XX6 8TB9 9IPU
Enriched GO Terms of Interacting Partners?		Cytosolic Ribosome RNA Import Into Nucleus RNA Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Importin-alpha Family Protein Binding Negative Regulation Of Ubiquitin Protein Ligase Activity Ubiquitin Ligase Inhibitor Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Nucleolus Cytoplasmic Translation Regulation Of Proteolysis MRNA 5'-UTR Binding Regulation Of Ubiquitin-protein Transferase Activity Ribonucleoprotein Complex Structural Constituent Of Ribosome Protein-containing Complex Nucleus Spindle Organization Negative Regulation Of Catalytic Activity Ribosome RRNA Binding Positive Regulation Of Binding Protein Domain Specific Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Catalytic Activity Protein Stabilization Cytosolic Large Ribosomal Subunit Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Negative Regulation Of Cell Development Response To Vitamin B2 C/EBP Complex Regulation Of Focal Adhesion Assembly Regulation Of Protein Modification Process Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Protein Ubiquitination Regulation Of Cell-substrate Junction Organization Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Chromatin DNA Binding CHOP-C/EBP Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleoplasm Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Positive Regulation Of Mitotic Cell Cycle Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Regulation Of Protein Localization To Nucleus Cytosol Regulation Of Mitotic Cell Cycle Acetylcholine Receptor Activator Activity Positive Regulation Of Establishment Of Protein Localization Nucleus Nuclear Import Signal Receptor Activity Regulation Of Mitotic Cell Cycle Phase Transition Nuclear Localization Sequence Binding G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Cell Cycle G1/S Phase Transition NLS-bearing Protein Import Into Nucleus Apoptotic Process Cyclin E1-CDK2 Complex Cyclin-dependent Protein Kinase Activity Positive Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Organelle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Nucleus Programmed Cell Death Cell Death Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Protein Transport Positive Regulation Of Protein Localization Positive Regulation Of Protein Transport Cyclin Binding Ribosomal Protein Import Into Nucleus Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle Phase Transition Regulation Of Nucleocytoplasmic Transport Intracellular Protein Localization Regulation Of Cell Cycle G2/M Phase Transition Protein Import Into Nucleus DNA Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Protein Import Into Nucleus Import Into Nucleus DNA Damage Response Histone Kinase Activity Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Protein Transport
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