HIST1H1B and KAT2B

Number of citations of the paper that reports this interaction (PMID 10373431)
62

Data Source:
BioGRID (enzymatic study)

		HIST1H1B	KAT2B
Gene Name		histone cluster 1, H1b	K(lysine) acetyltransferase 2B
Image
Gene Ontology Annotations	Cellular Component	Nucleosome Nuclear Chromatin Nuclear Heterochromatin Extracellular Vesicular Exosome	PCAF Complex Kinetochore Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex A Band I Band Actomyosin
	Molecular Function	Chromatin DNA Binding Histone Deacetylase Binding Poly(A) RNA Binding	Transcription Cofactor Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Transcription Factor Binding Acetyltransferase Activity Protein Kinase Binding Protein Complex Binding Histone Deacetylase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Nucleosome Assembly Positive Regulation Of Cell Growth Protein Stabilization Positive Regulation Of Histone H3-K9 Methylation Establishment Of Protein Localization To Chromatin	Chromatin Organization Chromatin Remodeling Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase II Promoter Protein Acetylation Cell Cycle Arrest Notch Signaling Pathway Negative Regulation Of Cell Proliferation Gene Expression Regulation Of Protein ADP-ribosylation Viral Process N-terminal Peptidyl-lysine Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Cellular Response To Insulin Stimulus Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3 Acetylation Histone H3-K9 Acetylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process
Pathways		DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Cellular Senescence Programmed Cell Death Apoptotic execution phase	Signaling by NOTCH1 HD Domain Mutants in Cancer RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HATs acetylate histones Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Chromatin organization RNA Polymerase I Transcription Signaling by NOTCH Notch-HLH transcription pathway NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer YAP1- and WWTR1 (TAZ)-stimulated gene expression Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: CBX5 CCNA1 CCNA2 CCNB1 CCNE1 CDK1 CDK2 CDK5 CDKN1A CDKN1B EHMT2 IRAK4 KAT2A KAT2B L3MBTL1 LOX MELK MLLT1 NSD1 PRKCA PRKCB PRKCD PRKCZ RPS6KA5 SERPINH1 SIRT1	116 interactors: ACTN1 ACTN2 AKT1 AR ARNTL ATF4 ATXN3 BRCA2 CCNA2 CCND1 CCNT1 CDC25B CDCA4 CDK2 CDKN1B CDT1 CEBPB CEP250 CIITA CLOCK CNTN2 CREBBP CTBP1 CTNNB1 CUX1 DACH2 DEK EP300 ESRRA ETV1 GATAD2A GATAD2B H3F3A HIPK2 HIST1H1A HIST1H1B HIST1H2AB HIST1H2BB HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST2H3C HIST3H3 HIST4H4 HMGA1 HMGN2 HNF1A HNRNPU HSD11B2 HTT ING1 IRF1 IRF2 IRF7 JDP2 KLF10 KLF13 KLF2 MAPK14 MAPRE1 MDM2 MECOM MYC MYOD1 NCOA1 NCOA3 NCOA4 NFATC1 NFE2 NFE4 NOTCH1 NOTCH3 NPAS2 NR1H3 NR4A1 NRIP1 ONECUT1 PARP1 PDK1 PGR PLAGL1 PNMA1 POLR2A PTF1A RAB11A RARA RB1 RBPJ RELA RPS6KB1 RPS6KB2 SAT2 SATB1 SERBP1 SERTAD1 SERTAD2 SIRT2 SMAD1 SMAD2 SMAD3 SRC SRCAP TACC2 TAL1 TCF3 TMF1 TP53 TP63 TP73 TTF1 TWIST1 UBE2D1 UBE2D3 XRCC6 YY1
Entrez ID		3009	8850
HPRD ID		00821	06780
Ensembl ID		ENSG00000184357	ENSG00000114166
Uniprot IDs		P16401	Q92831
PDB IDs		2FE2 2RHI	1CM0 1JM4 1N72 1WUG 1WUM 1ZS5 2RNW 2RNX 3GG3
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Histone Modification Peptidyl-amino Acid Modification Chromatin Modification Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Cell Cycle Regulation Of Cell Cycle Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Chromatin Organization Histone Phosphorylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Nitrogen Compound Metabolic Process Cellular Protein Modification Process Regulation Of Mitotic Cell Cycle Cell Cycle Process Negative Regulation Of Protein Phosphorylation Negative Regulation Of Cellular Metabolic Process G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Gene Expression Mitotic Cell Cycle Chromosome Organization Regulation Of Catalytic Activity Negative Regulation Of Phosphorylation Protein Phosphorylation G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cellular Protein Metabolic Process Response To Stress Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Metabolic Process Protein Metabolic Process Response To Wounding Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Protein Metabolic Process Peptidyl-threonine Phosphorylation Peptidyl-serine Phosphorylation Regulation Of RNA Metabolic Process Negative Regulation Of Protein Kinase Activity Regulation Of Metabolic Process Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Kinase Activity Positive Regulation Of Cell Proliferation Negative Regulation Of Protein Serine/threonine Kinase Activity Wound Healing	Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Chromosome Organization Chromatin Organization Response To Stress Regulation Of Cell Differentiation Response To Organic Substance Regulation Of Cell Proliferation Regulation Of Cellular Process Regulation Of Cell Cycle Cellular Response To Organic Substance Organelle Organization System Development Developmental Process Cellular Metabolic Process Anatomical Structure Development
Tagcloud ?			accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 homer1 kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1
Tagcloud (Difference) ?			accumbens brn2 decondensed dmnt1 dnmt3a erg1 exceptionally fox3 foxg1 gadd45a gadd45b hdac11 homer1 kat3a kat3b kat5 multilineage multipotent nef1 neg neun neurobiol neurobiology neuroplasticity nfl nuclei periodicals pons syt1
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