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HIST1H1B and KAT2A
Number of citations of the paper that reports this interaction (PMID
10373431
)
62
Data Source:
BioGRID
(enzymatic study)
HIST1H1B
KAT2A
Gene Name
histone cluster 1, H1b
K(lysine) acetyltransferase 2A
Image
Gene Ontology Annotations
Cellular Component
Nucleosome
Nuclear Chromatin
Nuclear Heterochromatin
Extracellular Vesicular Exosome
Extracellular Space
Nucleoplasm
Ada2/Gcn5/Ada3 Transcription Activator Complex
STAGA Complex
Transcription Factor TFTC Complex
Mitotic Spindle
Molecular Function
Chromatin DNA Binding
Histone Deacetylase Binding
Poly(A) RNA Binding
Chromatin Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Protein Binding
H3 Histone Acetyltransferase Activity
Histone Deacetylase Binding
Histone Acetyltransferase Activity (H4-K12 Specific)
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Chromatin Organization
Nucleosome Assembly
Positive Regulation Of Cell Growth
Protein Stabilization
Positive Regulation Of Histone H3-K9 Methylation
Establishment Of Protein Localization To Chromatin
In Utero Embryonic Development
Somitogenesis
Neural Tube Closure
Chromatin Organization
Chromatin Remodeling
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Cell Proliferation
Viral Process
Histone Deubiquitination
Telencephalon Development
Metencephalon Development
Midbrain Development
Regulation Of Protein Stability
Multicellular Organism Growth
Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter
Histone H3 Acetylation
Histone H4-K12 Acetylation
Histone H3-K14 Acetylation
Pathways
DNA Damage/Telomere Stress Induced Senescence
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Activation of DNA fragmentation factor
Apoptosis induced DNA fragmentation
Cellular Senescence
Programmed Cell Death
Apoptotic execution phase
Signaling by NOTCH1 HD Domain Mutants in Cancer
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Clearance
HATs acetylate histones
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Generic Transcription Pathway
Pre-NOTCH Transcription and Translation
Signaling by NOTCH1
Pre-NOTCH Expression and Processing
Signaling by NOTCH1 in Cancer
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
FBXW7 Mutants and NOTCH1 in Cancer
Chromatin organization
RNA Polymerase I Transcription
Signaling by NOTCH
Notch-HLH transcription pathway
NOTCH1 Intracellular Domain Regulates Transcription
Chromatin modifying enzymes
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS
Protein-Protein Interactions
26 interactors:
CBX5
CCNA1
CCNA2
CCNB1
CCNE1
CDK1
CDK2
CDK5
CDKN1A
CDKN1B
EHMT2
IRAK4
KAT2A
KAT2B
L3MBTL1
LOX
MELK
MLLT1
NSD1
PRKCA
PRKCB
PRKCD
PRKCZ
RPS6KA5
SERPINH1
SIRT1
45 interactors:
ATXN7
BATF2
BRCA1
CDK2
CEBPB
COMMD1
CREBBP
CRX
CTNNB1
CUL2
DTL
EID1
EP300
GATA2
HIST1H1B
HIST1H3A
HIST1H4A
HIST2H2AC
HIST2H2BE
HIST2H3C
HIST2H4A
HIST3H3
HIST4H4
HSD11B2
IRF1
IRF2
IRF7
MYB
MYC
NOTCH1
PBX1
PPARG
PRKDC
PYGO2
RBPJ
RELA
SIRT2
SUMO1
TACC1
TACC2
TACC3
TADA2A
TCF3
TRRAP
XRCC6
Entrez ID
3009
2648
HPRD ID
00821
03807
Ensembl ID
ENSG00000184357
ENSG00000108773
Uniprot IDs
P16401
Q92830
PDB IDs
2FE2
2RHI
1F68
1Z4R
3D7C
Enriched GO Terms of Interacting Partners
?
Regulation Of Protein Kinase Activity
Regulation Of Kinase Activity
Regulation Of Protein Phosphorylation
Histone Modification
Peptidyl-amino Acid Modification
Chromatin Modification
Regulation Of Phosphorylation
Regulation Of Cellular Protein Metabolic Process
Cell Cycle
Regulation Of Cell Cycle
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Metabolic Process
Chromatin Organization
Histone Phosphorylation
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Nitrogen Compound Metabolic Process
Cellular Protein Modification Process
Regulation Of Mitotic Cell Cycle
Cell Cycle Process
Negative Regulation Of Protein Phosphorylation
Negative Regulation Of Cellular Metabolic Process
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Process
Regulation Of Gene Expression
Mitotic Cell Cycle
Chromosome Organization
Regulation Of Catalytic Activity
Negative Regulation Of Phosphorylation
Protein Phosphorylation
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Cellular Protein Metabolic Process
Response To Stress
Response To Organic Substance
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Protein Metabolic Process
Protein Metabolic Process
Response To Wounding
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Cellular Protein Metabolic Process
Peptidyl-threonine Phosphorylation
Peptidyl-serine Phosphorylation
Regulation Of RNA Metabolic Process
Negative Regulation Of Protein Kinase Activity
Regulation Of Metabolic Process
Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Kinase Activity
Positive Regulation Of Cell Proliferation
Negative Regulation Of Protein Serine/threonine Kinase Activity
Wound Healing
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription, DNA-templated
Regulation Of Gene Expression
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Chromosome Organization
Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Response To Stress
Gene Expression
Cell Cycle
Chromatin Organization
Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
RNA Biosynthetic Process
Chromatin Silencing At RDNA
Regulation Of Cell Differentiation
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Type I Interferon Production
Organelle Organization
Regulation Of Metabolic Process
Immune System Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Regulation Of Type I Interferon Production
Negative Regulation Of Cell Differentiation
Chromatin Modification
DNA Methylation On Cytosine
Response To Abiotic Stimulus
Regulation Of Histone Modification
Chromatin Silencing
Regulation Of Chromosome Organization
Tagcloud
?
acetyltransferase
antiviral
correlates
cytoplasm
dispensable
enriched
establish
gcn5
h3k9
h3k9ac
hat
ifn
ifnb
immune
immunity
inhibiting
innate
instead
kat2b
pcaf
production
redundancy
regulators
repress
surprisingly
tbk1
triggers
turn
vast
Tagcloud (Difference)
?
acetyltransferase
antiviral
correlates
cytoplasm
dispensable
enriched
establish
gcn5
h3k9
h3k9ac
hat
ifn
ifnb
immune
immunity
inhibiting
innate
instead
kat2b
pcaf
production
redundancy
regulators
repress
surprisingly
tbk1
triggers
turn
vast
Tagcloud (Intersection)
?