H1-5 and SERPINH1

Number of citations of the paper that reports this interaction (PubMedID 11581402)
52

Data Source:
BioGRID (pull down)

		H1-5	SERPINH1
Description		H1.5 linker histone, cluster member	serpin family H member 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleosome Euchromatin Heterochromatin Nucleus Nucleoplasm Chromosome Nucleolus	Extracellular Space Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Extracellular Matrix Membrane Raft
	Molecular Function	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding Histone Deacetylase Binding	RNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Collagen Binding Unfolded Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Muscle Organ Development Chromosome Condensation Negative Regulation Of DNA Recombination Protein Stabilization Establishment Of Protein Localization To Chromatin	Chondrocyte Development Involved In Endochondral Bone Morphogenesis Response To Unfolded Protein Collagen Fibril Organization Collagen Biosynthetic Process Protein Maturation
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	Collagen biosynthesis and modifying enzymes
Drugs
Diseases
GWAS			A body shape index ( 34021172) Coronary artery disease ( 33020668 29212778) Height ( 22021425 33713608 31562340 28552196 28270201 25429064 25282103 20881960) Hip circumference adjusted for BMI ( 25673412 34021172) Myocardial infarction ( 33532862) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172)
Interacting Genes		32 interacting genes: CBX5 CCNA1 CCNA2 CCNB1 CCNE1 CDC42 CDK1 CDK2 CDK5 CDKN1A CDKN1B CEBPA EHMT2 HPF1 IRAK4 KAT2A KAT2B L3MBTL1 LOX MELK MLLT1 NSD1 PARP1 PARP2 PRKCA PRKCB PRKCD PRKCZ RIPK3 RPS6KA5 SERPINH1 SIRT1	20 interacting genes: BAG6 BRCA2 C1QL3 CD9 CDK9 CEP70 COL26A1 ESR2 FEZ1 H1-5 KAT2B KLF13 LINC01554 NSG2 OGT PPARG SLC2A4 SLC35F6 UBQLN4 UBTF
Entrez ID		3009	871
HPRD ID		00821	02968
Ensembl ID		ENSG00000184357	ENSG00000149257
Uniprot IDs		P16401	A8K259 P50454
PDB IDs		2RHI
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Protein Modification Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Chromatin Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Protein Serine Kinase Activity Chromatin Binding Protein Serine/threonine Kinase Activity Transferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of RNA Metabolic Process Kinase Activity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Nucleoplasm Regulation Of DNA Metabolic Process Protein Kinase Activity Regulation Of Cell Cycle Cellular Response To Oxygen-containing Compound Cellular Response To Stress Regulation Of Gene Expression Regulation Of Cell Cycle Process Regulation Of Macromolecule Biosynthetic Process Response To Stress Nucleus Protein Kinase Binding Cyclin A2-CDK2 Complex Negative Regulation Of Macromolecule Biosynthetic Process Protein Phosphorylation Protein Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Cycle Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Intracellular Signal Transduction Phosphorylation Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Positive Regulation Of DNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Negative Regulation Of RNA Metabolic Process Cell Cycle G2/M Phase Transition	Gamma-tubulin Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Carbon Catabolite Regulation Of Transcription Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Response To Insulin Regulation Of Transcription By Glucose Internal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation Negative Regulation Of Cellular Component Organization Cellular Response To Insulin Stimulus Regulation Of Cellular Response To Stress Chromatin Organization Regulation Of Cellular Component Organization Regulation Of Organelle Organization Histone Acetyltransferase Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Peptide Hormone Histone Acetyltransferase Activity Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Lipid Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Metabolic Process Response To Nutrient Protein Acetylation Replication Fork Processing BRCA2-MAGE-D1 Complex Positive Regulation Of RNA Metabolic Process Cellular Response To Lipoprotein Particle Stimulus Host-mediated Activation Of Viral Process Pyruvate Carboxylase Activity Positive Regulation Of Fatty Acid Metabolic Process Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Cellular Response To Nutrient Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Negative Regulation Of Macroautophagy Collagen Type XXVI Trimer Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
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