HIST1H1B and MELK

Number of citations of the paper that reports this interaction (PMID 16216881)
21

Data Source:
HPRD (in vitro)

		HIST1H1B	MELK
Gene Name		histone cluster 1, H1b	maternal embryonic leucine zipper kinase
Image
Gene Ontology Annotations	Cellular Component	Nucleosome Nuclear Chromatin Nuclear Heterochromatin Extracellular Vesicular Exosome	Plasma Membrane Cell Cortex Membrane
	Molecular Function	Chromatin DNA Binding Histone Deacetylase Binding Poly(A) RNA Binding	Protein Serine/threonine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Lipid Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Nucleosome Assembly Positive Regulation Of Cell Growth Protein Stabilization Positive Regulation Of Histone H3-K9 Methylation Establishment Of Protein Localization To Chromatin	G2/M Transition Of Mitotic Cell Cycle Apoptotic Process Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Peptidyl-tyrosine Phosphorylation Hemopoiesis Positive Regulation Of Apoptotic Process Protein Autophosphorylation Neural Precursor Cell Proliferation
Pathways		DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Cellular Senescence Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: CBX5 CCNA1 CCNA2 CCNB1 CCNE1 CDK1 CDK2 CDK5 CDKN1A CDKN1B EHMT2 IRAK4 KAT2A KAT2B L3MBTL1 LOX MELK MLLT1 NSD1 PRKCA PRKCB PRKCD PRKCZ RPS6KA5 SERPINH1 SIRT1	9 interactors: CDC25B CDC5L EIF2S1 HIST1H1B LMNB1 MBP PPP1R8 SF3B1 ZNF622
Entrez ID		3009	9833
HPRD ID		00821	06119
Ensembl ID		ENSG00000184357	ENSG00000165304
Uniprot IDs		P16401	B7Z1G6 Q14680
PDB IDs		2FE2 2RHI	4BKY 4BKZ 4BL1 4IXP
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Histone Modification Peptidyl-amino Acid Modification Chromatin Modification Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Cell Cycle Regulation Of Cell Cycle Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Chromatin Organization Histone Phosphorylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Nitrogen Compound Metabolic Process Cellular Protein Modification Process Regulation Of Mitotic Cell Cycle Cell Cycle Process Negative Regulation Of Protein Phosphorylation Negative Regulation Of Cellular Metabolic Process G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Gene Expression Mitotic Cell Cycle Chromosome Organization Regulation Of Catalytic Activity Negative Regulation Of Phosphorylation Protein Phosphorylation G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cellular Protein Metabolic Process Response To Stress Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Metabolic Process Protein Metabolic Process Response To Wounding Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cellular Protein Metabolic Process Peptidyl-threonine Phosphorylation Peptidyl-serine Phosphorylation Regulation Of RNA Metabolic Process Negative Regulation Of Protein Kinase Activity Regulation Of Metabolic Process Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Kinase Activity Positive Regulation Of Cell Proliferation Negative Regulation Of Protein Serine/threonine Kinase Activity Wound Healing	RNA Splicing MRNA Processing Positive Regulation Of Kinase Activity MRNA Metabolic Process Positive Regulation Of Transferase Activity RNA Processing Defense Response To Nematode
Tagcloud ?			axis caenorhabditis catalytic coexpressed collectively contributes driven elegans evolutionarily ezh2 foxm1 gbm glioblastoma gsc gscs inversely irradiation mitotic oncogenic phosphorylates polycomb possibility postirradiation radioresistance raise repressive serve tumorigenic turn
Tagcloud (Difference) ?			axis caenorhabditis catalytic coexpressed collectively contributes driven elegans evolutionarily ezh2 foxm1 gbm glioblastoma gsc gscs inversely irradiation mitotic oncogenic phosphorylates polycomb possibility postirradiation radioresistance raise repressive serve tumorigenic turn
Tagcloud (Intersection) ?