SOX17 and PKD1

  • Data Source: HiPPIP (Novel)

SOX17

PKD1

Name SRY-box transcription factor 17 polycystin 1, transient receptor potential channel interacting
Structure PDB 2YUL PDB 1B4R
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Diseases
GWAS
  • Apolipoprotein B levels ( 32203549 )
  • Cholesterol, total ( 24097068 )
  • Factor VIII levels ( 30586737 )
  • Intracranial aneurysm ( 20364137 33199917 18997786 )
  • LDL cholesterol ( 24097068 )
  • LDL cholesterol levels ( 28334899 30698716 32203549 )
  • LDL cholesterol levels in current drinkers ( 30698716 )
  • LDL cholesterol levels in HIV infection ( 33109212 )
  • LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 )
  • LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 )
  • Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 )
  • Lung cancer ( 28604730 )
  • Lung cancer in ever smokers ( 28604730 )
  • Pulmonary arterial hypertension ( 30527956 )
  • Total cholesterol levels ( 28334899 )
  • Appendicular lean mass ( 33097823 )
  • Dilated cardiomyopathy ( 33677556 )
  • Estimated glomerular filtration rate ( 31451708 )
  • Estimated glomerular filtration rate in non-diabetics ( 31451708 )
  • Heel bone mineral density ( 30598549 )
  • Height ( 28552196 )
  • High light scatter reticulocyte count ( 32888494 )
  • Hypertrophic cardiomyopathy (MTAG) ( 33495596 )
  • Low hand grip strength (60 years and older) (EWGSOP) ( 33510174 )
  • Major depressive disorder ( 29317602 )
  • Neutrophil count ( 32888494 )
  • Systolic blood pressure ( 30578418 )
  • Waist circumference adjusted for body mass index ( 34021172 )
Novel Interactors 1 novel interactors: PKD1 9 novel interactors: NADSYN1 NTHL1 NTN3 OR1F1 PDPK1 PPL RIGI RPL3L SOX17
Interacting Genes 4 interacting genes: CTNNB1 HNF1B NFIC NFIX 31 interacting genes: ACTN1 ATF7IP BCAR1 CDH1 COL1A1 COL2A1 CTNNA1 CTNNB1 DES FN1 HDAC9 JAK2 JUP KRT18 KRT8 LTB4R2 MARK2 NCF1 NCK2 PIP5K1C PKD2 PTK2 PTPRG PXN RGS7 RUNX1 SIAH1 SRC TLN1 VCL VIM
Entrez ID 64321 5310
HPRD ID 18085 03203
Ensembl ID ENSG00000164736 ENSG00000008710
Uniprot IDs Q9H6I2 P98161
PDB IDs 2YUL 4A3N 1B4R 6A70
GO Terms Enriched among Interactors