SOX17 and NFIX

Number of citations: 106 (PubMedID 35140242)
Data Source: BioGRID (pull down)

		SOX17	NFIX
Name		SRY-box transcription factor 17	nuclear factor I X
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Chromatin Nucleus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Angiogenesis Vasculogenesis Metanephros Development Endoderm Formation Endodermal Cell Fate Specification Inner Cell Mass Cellular Morphogenesis Heart Looping Cardiogenic Plate Morphogenesis Embryonic Heart Tube Morphogenesis Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Gastrulation Endoderm Development Endodermal Cell Fate Determination Heart Development Tissue Development Gene Expression Positive Regulation Of Gene Expression Wnt Signaling Pathway Rostrocaudal Neural Tube Patterning Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Protein Destabilization Embryonic Heart Tube Development Endodermal Cell Differentiation Cell Migration Involved In Gastrulation Response To Alkaloid Regulation Of Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Embryonic Organ Development Embryonic Foregut Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Stem Cell Differentiation Stem Cell Fate Specification Protein Stabilization Endocardium Formation Cardiac Cell Fate Determination Heart Formation Endocardial Cell Differentiation Common Bile Duct Development Gallbladder Development Endodermal Digestive Tract Morphogenesis Regulation Of Stem Cell Proliferation Ureter Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Endodermal Cell Differentiation Cellular Response To Leukemia Inhibitory Factor Regulation Of Stem Cell Division Regulation Of Cardiac Cell Fate Specification Positive Regulation Of Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Deactivation of the beta-catenin transactivating complex Formation of definitive endoderm Specification of primordial germ cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells	RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Diseases		Vesicoureteral reflux	None
GWAS		Apolipoprotein B levels ( 32203549 ) Cholesterol, total ( 24097068 ) Factor VIII levels ( 30586737 ) Intracranial aneurysm ( 20364137 33199917 18997786 ) LDL cholesterol ( 24097068 ) LDL cholesterol levels ( 28334899 30698716 32203549 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels in HIV infection ( 33109212 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Lung cancer ( 28604730 ) Lung cancer in ever smokers ( 28604730 ) Pulmonary arterial hypertension ( 30527956 ) Total cholesterol levels ( 28334899 )	Bipolar disorder ( 28115744 ) Body mass index ( 25673413 ) Brain morphology (MOSTest) ( 32665545 ) Clozapine-induced agranulocytosis ( 25187353 ) Cortical surface area ( 32963231 ) Cortical volume ( 32963231 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Heel bone mineral density ( 30598549 ) Hemoglobin ( 32888494 ) Hip index ( 34021172 ) Intelligence (MTAG) ( 29326435 ) Lymphocyte count ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Monocyte count ( 32888494 27863252 ) Monocyte percentage of white cells ( 32888494 27863252 ) Plateletcrit ( 32888494 ) Refractive error ( 32231278 )
Novel Interactors		1 novel interactors: PKD1	8 novel interactors: ARL4A GADD45B GZMA MATK MLLT1 NRTN POLR2E RWDD1
Interacting Genes		4 interacting genes: CTNNB1 HNF1B NFIC NFIX	24 interacting genes: JMJD6 LHX4 NFIB PAX2 PAX6 PAX7 PAX8 PIR PRDM1 QRICH1 RFX1 SKI SOX10 SOX15 SOX17 SOX5 SOX6 SOX9 SP7 TBR1 TLX2 TLX3 YY1 ZNF614
Entrez ID		64321	4784
HPRD ID		18085	01234
Ensembl ID		ENSG00000164736	ENSG00000008441
Uniprot IDs		Q9H6I2	B4DHW2 D2DXM9 Q14938
PDB IDs		2YUL 4A3N	7QQD 7QQE
GO Terms Enriched among Interactors		Genitalia Development Nephric Duct Development Mesonephric Duct Development Positive Regulation Of Transcription By RNA Polymerase II Nephron Tubule Formation Epithelial Tube Morphogenesis Animal Organ Morphogenesis Branching Morphogenesis Of An Epithelial Tube Nephron Tubule Morphogenesis Positive Regulation Of RNA Biosynthetic Process Kidney Morphogenesis Kidney Development Morphogenesis Of A Branching Structure Morphogenesis Of A Branching Epithelium Positive Regulation Of DNA-templated Transcription Renal Tubule Morphogenesis Hindbrain Development Positive Regulation Of RNA Metabolic Process Reproductive Structure Development Nephron Tubule Development Embryonic Epithelial Tube Formation Tube Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Renal Tubule Development Pancreas Development Epithelium Development Epithelial Tube Formation Gland Development Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Tube Morphogenesis Regulation Of Transcription By RNA Polymerase II Transcription Coregulator Binding Detection Of Mechanical Stimulus Morphogenesis Of An Epithelium Positive Regulation Of Macromolecule Biosynthetic Process Mesonephric Tubule Development Mesonephric Epithelium Development Skin Development Positive Regulation Of Biosynthetic Process Tissue Morphogenesis DNA-templated Transcription Lateral Plasma Membrane Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Odontogenesis Of Dentin-containing Tooth Kidney Epithelium Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Chromatin DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Animal Organ Development Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cellular Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Positive Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Metanephric Nephron Tubule Formation Regulation Of Gene Expression Cell Fate Commitment Gene Expression Regulation Of Macromolecule Biosynthetic Process Glial Cell Differentiation Negative Regulation Of Developmental Process Metanephric Tubule Formation Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Macromolecule Metabolic Process Lacrimal Gland Development Developmental Process Glial Cell Fate Specification Ureter Development Regulation Of Developmental Process Regulation Of Cell Differentiation Neuron Differentiation Positive Regulation Of Macromolecule Metabolic Process Retina Development In Camera-type Eye Regulation Of Stem Cell Differentiation Pattern Specification Process Regionalization