CXCR5 and PLS3

Data Source: HiPPIP (Novel)

		CXCR5	PLS3
Name		C-X-C motif chemokine receptor 5	plastin 3
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Cytoplasm Cytosol Actin Filament Plasma Membrane Neuromuscular Junction Actin Filament Bundle
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding	Actin Binding Calcium Ion Binding Metal Ion Binding Actin Filament Binding Structural Constituent Of Presynaptic Actin Cytoskeleton
	Biological Process	Chemotaxis Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Leukocyte Chemotaxis Positive Regulation Of Cytokinesis B Cell Activation Lymph Node Development Cell Chemotaxis Chemokine-mediated Signaling Pathway	Actin Filament Bundle Assembly Actin Filament Network Formation Bone Development Regulation Of Synaptic Vesicle Cycle Presynaptic Actin Cytoskeleton Organization
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	None
GWAS		Albumin-globulin ratio ( 29403010 ) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic rhinitis ( 30013184 ) Allergy ( 27182965 ) Asthma ( 34103634 32296059 31959851 30929738 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 30929738 31036433 ) Asthma onset (childhood vs adult) ( 30929738 ) Celiac disease and Rheumatoid arthritis ( 26546613 ) Follicular lymphoma ( 25279986 ) Human herpes virus 7 U14 antibody levels ( 33204752 ) Inflammatory bowel disease ( 23128233 ) Multiple sclerosis ( 21833088 24076602 ) Post-bronchodilator lung function in asthma (FVC) ( 32989782 ) Primary biliary cholangitis ( 21399635 26394269 28425483 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 30423114 24390342 ) Sjögren's syndrome ( 24097067 ) Systemic lupus erythematosus ( 32771030 ) Trunk fat mass ( 28552196 ) Vitiligo ( 22951725 )	Gestational age at birth (maternal effect) ( 28877031 ) Mean platelet volume ( 32888494 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 ) Preterm birth (maternal effect) ( 28877031 )
Novel Interactors		6 novel interactors: ARCN1 CBL DPAGT1 MRE11 PLS3 TLK1	14 novel interactors: ACRV1 ASGR1 CUL4B CXCR5 FRYL LRCH2 NRSN1 PTPN5 TGIF2 TRPC5 TSPAN32 WFDC2 ZBTB33 ZNF195
Interacting Genes		1 interacting genes: CXCL13	5 interacting genes: APP ATXN2 FILNC1 OGT SNCA
Entrez ID		643	5358
HPRD ID		03367	02133
Ensembl ID		ENSG00000160683	ENSG00000102024
Uniprot IDs		A0N0R2 A8K647 P32302 Q2YD84	B4DPW9 P13797
PDB IDs		Not available	1AOA 1WJO 7R94 7SX8 7SX9 7SXA
GO Terms Enriched among Interactors		Regulation Of Rap Protein Signal Transduction UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase Activity Mitochondrial Double-strand Break Repair Via Homologous Recombination Structural Constituent Of Presynaptic Actin Cytoskeleton CXCR5 Chemokine Receptor Binding Lymphocyte Chemotaxis Across High Endothelial Venule Endothelial Cell Chemotaxis To Fibroblast Growth Factor Cerebellar Purkinje Cell Layer Maturation UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase Activity Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Negative Regulation Of Cell Chemotaxis To Fibroblast Growth Factor CCR10 Chemokine Receptor Binding Ubiquitin-dependent Endocytosis Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Meiotic DNA Double-strand Break Formation Mre11 Complex BRCA1-C Complex Chromosomal Region Telomeric 3' Overhang Formation Presynaptic Actin Cytoskeleton Organization Actin Filament Network Formation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin CXCR3 Chemokine Receptor Binding Negative Regulation Of Endothelial Cell Chemotaxis B Cell Chemotaxis DNA Damage Response Regulation Of Mitotic Recombination Presynaptic Cytoskeleton Organization Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor	Growth Cone Amyloid-beta Complex Regulation Of Synapse Assembly Growth Cone Lamellipodium Regulation Of Presynapse Organization Response To Copper Ion Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Neuron Differentiation Regulation Of Presynapse Assembly Regulation Of Protein Catabolic Process Amyloid Fibril Formation Regulation Of Neurotransmitter Uptake Microglial Cell Activation Regulation Of Generation Of Precursor Metabolites And Energy Leukocyte Activation Involved In Inflammatory Response Cellular Response To Copper Ion Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cysteine-type Endopeptidase Inhibitor Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Neuron Differentiation