PLS3 and TGIF2

		PLS3	TGIF2
Description		plastin 3	TGFB induced factor homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Plasma Membrane Neuromuscular Junction Actin Filament Bundle	Chromatin Nucleus Nucleoplasm Centrosome
	Molecular Function	Actin Binding Calcium Ion Binding Metal Ion Binding Actin Filament Binding Structural Constituent Of Presynaptic Actin Cytoskeleton	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Actin Filament Bundle Assembly Actin Filament Network Formation Bone Development Regulation Of Synaptic Vesicle Cycle Presynaptic Actin Cytoskeleton Organization	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Gastrulation Neuron Differentiation Amacrine Cell Differentiation Nodal Signaling Pathway Retina Development In Camera-type Eye Positive Regulation Of Amacrine Cell Differentiation
Pathways			Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Negative Regulation of CDH1 Gene Transcription
Drugs
Diseases
GWAS		Gestational age at birth (maternal effect) ( 28877031) Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494) Preterm birth (maternal effect) ( 28877031)
Interacting Genes		5 interacting genes: APP ATXN2 FILNC1 OGT SNCA	5 interacting genes: FBXO7 HDAC1 RBBP8 SMAD3 TARBP2
Entrez ID		5358	60436
HPRD ID		02133	06293
Ensembl ID		ENSG00000102024	ENSG00000118707
Uniprot IDs		B4DPW9 P13797	Q9GZN2
PDB IDs		1AOA 1WJO 7R94 7SX8 7SX9 7SXA
Enriched GO Terms of Interacting Partners?		Growth Cone Amyloid-beta Complex Regulation Of Synapse Assembly Growth Cone Lamellipodium Regulation Of Presynapse Organization Response To Copper Ion Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Neuron Differentiation Regulation Of Presynapse Assembly Regulation Of Protein Catabolic Process Amyloid Fibril Formation Regulation Of Neurotransmitter Uptake Microglial Cell Activation Regulation Of Generation Of Precursor Metabolites And Energy Leukocyte Activation Involved In Inflammatory Response Cellular Response To Copper Ion Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cysteine-type Endopeptidase Inhibitor Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Neuron Differentiation	RNA Polymerase II-specific DNA-binding Transcription Factor Binding Endoderm Development MiRNA Processing Enzyme Binding Transcription Repressor Complex Promoter-specific Chromatin Binding Transcription Corepressor Binding Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Structural Constituent Of Presynaptic Actin Cytoskeleton Regulation Of SiRNA Processing Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Ubiquitin Binding Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Krueppel-associated Box Domain Binding Positive Regulation Of Transforming Growth Factor Beta3 Production Regulation Of Muscle Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Decrotonylase Activity Negative Regulation Of Cell Differentiation Histone Decrotonylase Activity Protein Lysine Delactylase Activity Fungiform Papilla Formation Regulation Of Cell Differentiation Sterol Response Element Binding Regulation Of Lung Blood Pressure Paraxial Mesoderm Morphogenesis Negative Regulation Of Mitotic Cell Cycle Phase Transition Global Gene Silencing By MRNA Cleavage Negative Regulation Of Defense Response To Virus By Host Lewy Body Core Negative Regulation Of Intracellular Signal Transduction DNA-binding Transcription Factor Binding Hair Follicle Placode Formation Regulation Of Intrinsic Apoptotic Signaling Pathway Mesoderm Morphogenesis Immune System Development Transcription Corepressor Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Transdifferentiation SMAD Protein Complex Pericardium Development Trophoblast Cell Migration Presynaptic Cytoskeleton Organization Presynaptic Actin Cytoskeleton Organization
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