PLS3 and ZNF195

		PLS3	ZNF195
Description		plastin 3	zinc finger protein 195
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Plasma Membrane Neuromuscular Junction Actin Filament Bundle	Nucleus
	Molecular Function	Actin Binding Calcium Ion Binding Metal Ion Binding Actin Filament Binding Structural Constituent Of Presynaptic Actin Cytoskeleton	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Actin Filament Bundle Assembly Actin Filament Network Formation Bone Development Regulation Of Synaptic Vesicle Cycle Presynaptic Actin Cytoskeleton Organization	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways			Generic Transcription Pathway
Drugs
Diseases
GWAS		Gestational age at birth (maternal effect) ( 28877031) Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494) Preterm birth (maternal effect) ( 28877031)	Malaria ( 31844061)
Interacting Genes		5 interacting genes: APP ATXN2 FILNC1 OGT SNCA	1 interacting genes: PCBD1
Entrez ID		5358	7748
HPRD ID		02133	03718
Ensembl ID		ENSG00000102024	ENSG00000005801
Uniprot IDs		B4DPW9 P13797	O14628
PDB IDs		1AOA 1WJO 7R94 7SX8 7SX9 7SXA
Enriched GO Terms of Interacting Partners?		Growth Cone Amyloid-beta Complex Regulation Of Synapse Assembly Growth Cone Lamellipodium Regulation Of Presynapse Organization Response To Copper Ion Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Neuron Differentiation Regulation Of Presynapse Assembly Regulation Of Protein Catabolic Process Amyloid Fibril Formation Regulation Of Neurotransmitter Uptake Microglial Cell Activation Regulation Of Generation Of Precursor Metabolites And Energy Leukocyte Activation Involved In Inflammatory Response Cellular Response To Copper Ion Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cysteine-type Endopeptidase Inhibitor Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Neuron Differentiation	4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Structural Constituent Of Presynaptic Actin Cytoskeleton Intracellular Protein-containing Complex Positive Regulation Of Vesicle Transport Along Microtubule Presynaptic Actin Cytoskeleton Organization Actin Filament Network Formation LRR Domain Binding Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Tetrahydrobiopterin Biosynthetic Process Presynaptic Cytoskeleton Organization Tetrahydrobiopterin Metabolic Process Actin Filament Bundle Regulation Of Organelle Transport Along Microtubule Epithelial Cell Proliferation Involved In Prostate Gland Development Dendrite Extension Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Thymic T Cell Selection Anoikis Pteridine-containing Compound Biosynthetic Process Regulation Of Synaptic Vesicle Cycle Positive T Cell Selection Cellular Response To UV-B Golgi Localization G1 To G0 Transition Tyrosine Metabolic Process Serine/threonine Protein Kinase Complex Thymic T Cell Selection Peptidyl-threonine Phosphorylation Response To UV-B Diol Metabolic Process T Cell Selection Pteridine-containing Compound Metabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
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