CXCR5 and ARCN1

Data Source: HiPPIP (Novel)

		CXCR5	ARCN1
Name		C-X-C motif chemokine receptor 5	archain 1 coat protein complex I subunit delta
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane COPI Vesicle Coat Transport Vesicle COPI-coated Vesicle COPI-coated Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding	RNA Binding Protein Binding
	Biological Process	Chemotaxis Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Leukocyte Chemotaxis Positive Regulation Of Cytokinesis B Cell Activation Lymph Node Development Cell Chemotaxis Chemokine-mediated Signaling Pathway	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Adult Locomotory Behavior Protein Transport Vesicle-mediated Transport Cerebellar Purkinje Cell Layer Maturation Pigmentation Golgi Vesicle Transport Golgi Localization Establishment Of Localization In Cell
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
GWAS		Albumin-globulin ratio ( 29403010 ) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic rhinitis ( 30013184 ) Allergy ( 27182965 ) Asthma ( 34103634 32296059 31959851 30929738 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 30929738 31036433 ) Asthma onset (childhood vs adult) ( 30929738 ) Celiac disease and Rheumatoid arthritis ( 26546613 ) Follicular lymphoma ( 25279986 ) Human herpes virus 7 U14 antibody levels ( 33204752 ) Inflammatory bowel disease ( 23128233 ) Multiple sclerosis ( 21833088 24076602 ) Post-bronchodilator lung function in asthma (FVC) ( 32989782 ) Primary biliary cholangitis ( 21399635 26394269 28425483 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 30423114 24390342 ) Sjögren's syndrome ( 24097067 ) Systemic lupus erythematosus ( 32771030 ) Trunk fat mass ( 28552196 ) Vitiligo ( 22951725 )	Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 )
Novel Interactors		6 novel interactors: ARCN1 CBL DPAGT1 MRE11 PLS3 TLK1	1 novel interactors: CXCR5
Interacting Genes		1 interacting genes: CXCL13	13 interacting genes: APP COPA COPB1 COPB2 COPG1 COPG2 COPZ2 DSCAM HMGB2 LBHD1 PDE4B TMED10 WBP2
Entrez ID		643	372
HPRD ID		03367	02893
Ensembl ID		ENSG00000160683	ENSG00000095139
Uniprot IDs		A0N0R2 A8K647 P32302 Q2YD84	B0YIW5 P48444
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of Rap Protein Signal Transduction UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase Activity Mitochondrial Double-strand Break Repair Via Homologous Recombination Structural Constituent Of Presynaptic Actin Cytoskeleton CXCR5 Chemokine Receptor Binding Lymphocyte Chemotaxis Across High Endothelial Venule Endothelial Cell Chemotaxis To Fibroblast Growth Factor Cerebellar Purkinje Cell Layer Maturation UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase Activity Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Negative Regulation Of Cell Chemotaxis To Fibroblast Growth Factor CCR10 Chemokine Receptor Binding Ubiquitin-dependent Endocytosis Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Meiotic DNA Double-strand Break Formation Mre11 Complex BRCA1-C Complex Chromosomal Region Telomeric 3' Overhang Formation Presynaptic Actin Cytoskeleton Organization Actin Filament Network Formation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin CXCR3 Chemokine Receptor Binding Negative Regulation Of Endothelial Cell Chemotaxis B Cell Chemotaxis DNA Damage Response Regulation Of Mitotic Recombination Presynaptic Cytoskeleton Organization Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor	COPI Vesicle Coat COPI-coated Vesicle Membrane Intra-Golgi Vesicle-mediated Transport Transport Vesicle Membrane Coat COPI-coated Vesicle Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Vesicle Transport Cytoplasmic Vesicle Intracellular Protein Transport Structural Molecule Activity Golgi Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Vesicle-mediated Transport Intracellular Transport Establishment Of Protein Localization Golgi Apparatus Growth Cone Cellular Localization Establishment Of Localization In Cell Endoplasmic Reticulum Membrane Protein Transport RAGE Receptor Binding Golgi-associated Vesicle Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Chemotaxis Locomotion Intracellular Protein Localization Chemoattractant Activity Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Cytokine Production Regulation Of CAMP/PKA Signal Transduction Positive Chemotaxis Neuron Recognition Cell Chemotaxis Secretion Amyloid-beta Complex Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Microtubule-based Transport Amylin Binding Positive Regulation Of Toll Signaling Pathway Cytosol To ERGIC Protein Transport Cis-Golgi Network Protein Localization To ERGIC COPI-coated Vesicle Budding Positive Regulation Of Gene Expression, Epigenetic