PLS3 and LRCH2

		PLS3	LRCH2
Description		plastin 3	leucine rich repeats and calponin homology domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Plasma Membrane Neuromuscular Junction Actin Filament Bundle
	Molecular Function	Actin Binding Calcium Ion Binding Metal Ion Binding Actin Filament Binding Structural Constituent Of Presynaptic Actin Cytoskeleton	Protein Binding
	Biological Process	Actin Filament Bundle Assembly Actin Filament Network Formation Bone Development Regulation Of Synaptic Vesicle Cycle Presynaptic Actin Cytoskeleton Organization
Pathways
Drugs
Diseases
GWAS		Gestational age at birth (maternal effect) ( 28877031) Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494) Preterm birth (maternal effect) ( 28877031)
Interacting Genes		5 interacting genes: APP ATXN2 FILNC1 OGT SNCA	1 interacting genes: TEX11
Entrez ID		5358	57631
HPRD ID		02133	06602
Ensembl ID		ENSG00000102024	ENSG00000130224
Uniprot IDs		B4DPW9 P13797	Q5VUJ6
PDB IDs		1AOA 1WJO 7R94 7SX8 7SX9 7SXA
Enriched GO Terms of Interacting Partners?		Growth Cone Amyloid-beta Complex Regulation Of Synapse Assembly Growth Cone Lamellipodium Regulation Of Presynapse Organization Response To Copper Ion Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Neuron Differentiation Regulation Of Presynapse Assembly Regulation Of Protein Catabolic Process Amyloid Fibril Formation Regulation Of Neurotransmitter Uptake Microglial Cell Activation Regulation Of Generation Of Precursor Metabolites And Energy Leukocyte Activation Involved In Inflammatory Response Cellular Response To Copper Ion Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cysteine-type Endopeptidase Inhibitor Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Neuron Differentiation	Structural Constituent Of Presynaptic Actin Cytoskeleton Meiotic Gene Conversion Gene Conversion Male Meiosis Chromosome Segregation Presynaptic Actin Cytoskeleton Organization Actin Filament Network Formation Chiasma Assembly Presynaptic Cytoskeleton Organization Central Element Actin Filament Bundle Regulation Of Synaptic Vesicle Cycle Meiotic Chromosome Segregation Resolution Of Meiotic Recombination Intermediates Ectopic Germ Cell Programmed Cell Death Synaptonemal Complex Programmed Cell Death Involved In Cell Development Synaptonemal Complex Assembly Synaptonemal Complex Organization Reciprocal Meiotic Recombination Homologous Recombination Chromosome Organization Involved In Meiotic Cell Cycle Condensed Nuclear Chromosome Nuclear Chromosome Segregation Male Meiotic Nuclear Division Animal Organ Development Bone Development Actin Filament Bundle Assembly Actin Filament Bundle Organization Negative Regulation Of Reproductive Process Meiosis I Cell Cycle Process Meiotic Nuclear Division Neuromuscular Junction Actin Filament Nuclear Division Male Gonad Development Meiotic Cell Cycle Chromosome Segregation Fertilization Gonad Development Cellular Component Assembly Organelle Organization Regulation Of Reproductive Process Reproductive Structure Development Actin Filament Binding
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