CXCR5 and DPAGT1

Data Source: HiPPIP (Novel)

		CXCR5	DPAGT1
Name		C-X-C motif chemokine receptor 5	dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase Activity UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Phosphotransferase Activity, For Other Substituted Phosphate Groups Identical Protein Binding Metal Ion Binding
	Biological Process	Chemotaxis Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Leukocyte Chemotaxis Positive Regulation Of Cytokinesis B Cell Activation Lymph Node Development Cell Chemotaxis Chemokine-mediated Signaling Pathway	Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective DPAGT1 causes CDG-1j, CMSTA2
Diseases		None	Congenital disorders of glycosylation (CDG) type I
GWAS		Albumin-globulin ratio ( 29403010 ) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic rhinitis ( 30013184 ) Allergy ( 27182965 ) Asthma ( 34103634 32296059 31959851 30929738 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 30929738 31036433 ) Asthma onset (childhood vs adult) ( 30929738 ) Celiac disease and Rheumatoid arthritis ( 26546613 ) Follicular lymphoma ( 25279986 ) Human herpes virus 7 U14 antibody levels ( 33204752 ) Inflammatory bowel disease ( 23128233 ) Multiple sclerosis ( 21833088 24076602 ) Post-bronchodilator lung function in asthma (FVC) ( 32989782 ) Primary biliary cholangitis ( 21399635 26394269 28425483 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 30423114 24390342 ) Sjögren's syndrome ( 24097067 ) Systemic lupus erythematosus ( 32771030 ) Trunk fat mass ( 28552196 ) Vitiligo ( 22951725 )	Estimated glomerular filtration rate ( 31152163 ) Lymphocyte percentage of white cells ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 )
Interacting Genes		1 interacting genes: CXCL13	2 interacting genes: LSM8 SLC33A2
Entrez ID		643	1798
HPRD ID		03367	01879
Ensembl ID		ENSG00000160683	ENSG00000172269
Uniprot IDs		A0N0R2 A8K647 P32302 Q2YD84	A0A804HI18 A0A804HKZ3 Q9H3H5
PDB IDs		Not available	5LEV 5O5E 6BW5 6BW6 6FM9 6FWZ 6JQ3
GO Terms Enriched among Interactors		Regulation Of Rap Protein Signal Transduction UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase Activity Mitochondrial Double-strand Break Repair Via Homologous Recombination Structural Constituent Of Presynaptic Actin Cytoskeleton CXCR5 Chemokine Receptor Binding Lymphocyte Chemotaxis Across High Endothelial Venule Endothelial Cell Chemotaxis To Fibroblast Growth Factor Cerebellar Purkinje Cell Layer Maturation UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase Activity Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Negative Regulation Of Cell Chemotaxis To Fibroblast Growth Factor CCR10 Chemokine Receptor Binding Ubiquitin-dependent Endocytosis Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Meiotic DNA Double-strand Break Formation Mre11 Complex BRCA1-C Complex Chromosomal Region Telomeric 3' Overhang Formation Presynaptic Actin Cytoskeleton Organization Actin Filament Network Formation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin CXCR3 Chemokine Receptor Binding Negative Regulation Of Endothelial Cell Chemotaxis B Cell Chemotaxis DNA Damage Response Regulation Of Mitotic Recombination Presynaptic Cytoskeleton Organization Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor	None