PLS3 and ZBTB33

		PLS3	ZBTB33
Description		plastin 3	zinc finger and BTB domain containing 33
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GO Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Plasma Membrane Neuromuscular Junction Actin Filament Bundle	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Actin Binding Calcium Ion Binding Metal Ion Binding Actin Filament Binding Structural Constituent Of Presynaptic Actin Cytoskeleton	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Actin Filament Bundle Assembly Actin Filament Network Formation Bone Development Regulation Of Synaptic Vesicle Cycle Presynaptic Actin Cytoskeleton Organization	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process Wnt Signaling Pathway Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription
Pathways			Negative Regulation of CDH1 Gene Transcription
Drugs
Diseases
GWAS		Gestational age at birth (maternal effect) ( 28877031) Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494) Preterm birth (maternal effect) ( 28877031)
Interacting Genes		5 interacting genes: APP ATXN2 FILNC1 OGT SNCA	9 interacting genes: CBFA2T3 CTNND1 GSDMD GYS1 NCOR1 NUDT22 SUMO2 SUMO3 TRIM28
Entrez ID		5358	10009
HPRD ID		02133	02269
Ensembl ID		ENSG00000102024	ENSG00000177485
Uniprot IDs		B4DPW9 P13797	Q86T24
PDB IDs		1AOA 1WJO 7R94 7SX8 7SX9 7SXA	2LT7 3FKC 3M4T 3M8V 4F6M 4F6N 5VMU 5VMV 5VMW 5VMX 5VMY 5VMZ 6DF5 6DF8 6DF9 6DFA 6DFB 6DFC 6V8U
Enriched GO Terms of Interacting Partners?		Growth Cone Amyloid-beta Complex Regulation Of Synapse Assembly Growth Cone Lamellipodium Regulation Of Presynapse Organization Response To Copper Ion Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Neuron Differentiation Regulation Of Presynapse Assembly Regulation Of Protein Catabolic Process Amyloid Fibril Formation Regulation Of Neurotransmitter Uptake Microglial Cell Activation Regulation Of Generation Of Precursor Metabolites And Energy Leukocyte Activation Involved In Inflammatory Response Cellular Response To Copper Ion Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cysteine-type Endopeptidase Inhibitor Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Neuron Differentiation	Protein Sumoylation Negative Regulation Of Glycolytic Process Regulation Of Generation Of Precursor Metabolites And Energy Protein Tag Activity SUMO Transferase Activity Negative Regulation Of D-glucose Transmembrane Transport Negative Regulation Of ATP Metabolic Process Ubiquitin-like Protein Ligase Binding Transcription Corepressor Activity Regulation Of Glycolytic Process Negative Regulation Of Blood Vessel Branching Structural Constituent Of Presynaptic Actin Cytoskeleton GDP-mannose Hydrolase Activity Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of D-glucose Transmembrane Transport Glycogen Synthase Activity, Transferring Glucose-1-phosphate Krueppel-associated Box Domain Binding Derlin-1-VIMP Complex UDP-sugar Diphosphatase Activity Alpha-1,4-glucan Glucosyltransferase (UDP-glucose Donor) Activity Ubiquitin-like Protein Ligase Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Negative Regulation Of Small Molecule Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Transmembrane Transport Positive Regulation Of Protein Localization To Cell-cell Junction Embryonic Placenta Morphogenesis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Localization To Cell-cell Junction Presynaptic Actin Cytoskeleton Organization Actin Filament Network Formation Convergent Extension Involved In Axis Elongation Chromo Shadow Domain Binding Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus
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