PLS3 and WFDC2

		PLS3	WFDC2
Description		plastin 3	WAP four-disulfide core domain 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Plasma Membrane Neuromuscular Junction Actin Filament Bundle	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Actin Binding Calcium Ion Binding Metal Ion Binding Actin Filament Binding Structural Constituent Of Presynaptic Actin Cytoskeleton	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Aspartic-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity
	Biological Process	Actin Filament Bundle Assembly Actin Filament Network Formation Bone Development Regulation Of Synaptic Vesicle Cycle Presynaptic Actin Cytoskeleton Organization	Proteolysis Spermatogenesis Antibacterial Humoral Response Innate Immune Response
Pathways			Formation of the nephric duct
Drugs
Diseases
GWAS		Gestational age at birth (maternal effect) ( 28877031) Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494) Preterm birth (maternal effect) ( 28877031)	Brain structure ( 20171287)
Interacting Genes		5 interacting genes: APP ATXN2 FILNC1 OGT SNCA	15 interacting genes: ARL13B CD79A COQ9 CPLX4 CREB3L1 CYB5R3 FAM209A FKBP7 GORAB LMNA PANX1 PTN SLC22A23 STOM TMX2
Entrez ID		5358	10406
HPRD ID		02133	11684
Ensembl ID		ENSG00000102024	ENSG00000101443
Uniprot IDs		B4DPW9 P13797	A0A384MTN6 Q14508
PDB IDs		1AOA 1WJO 7R94 7SX8 7SX9 7SXA
Enriched GO Terms of Interacting Partners?		Growth Cone Amyloid-beta Complex Regulation Of Synapse Assembly Growth Cone Lamellipodium Regulation Of Presynapse Organization Response To Copper Ion Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Neuron Differentiation Regulation Of Presynapse Assembly Regulation Of Protein Catabolic Process Amyloid Fibril Formation Regulation Of Neurotransmitter Uptake Microglial Cell Activation Regulation Of Generation Of Precursor Metabolites And Energy Leukocyte Activation Involved In Inflammatory Response Cellular Response To Copper Ion Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cysteine-type Endopeptidase Inhibitor Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Neuron Differentiation
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