PLS3 and TSPAN32

		PLS3	TSPAN32
Description		plastin 3	tetraspanin 32
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Plasma Membrane Neuromuscular Junction Actin Filament Bundle	Plasma Membrane Cell Surface Membrane Integrin AlphaIIb-beta3 Complex
	Molecular Function	Actin Binding Calcium Ion Binding Metal Ion Binding Actin Filament Binding Structural Constituent Of Presynaptic Actin Cytoskeleton
	Biological Process	Actin Filament Bundle Assembly Actin Filament Network Formation Bone Development Regulation Of Synaptic Vesicle Cycle Presynaptic Actin Cytoskeleton Organization	Cytoskeleton Organization Cell Communication Integrin-mediated Signaling Pathway Cell-cell Signaling Blood Coagulation Hemostasis Signaling Negative Regulation Of Myeloid Dendritic Cell Activation T Cell Proliferation Negative Regulation Of T Cell Proliferation Defense Response To Protozoan Regulation Of Defense Response To Virus Platelet Aggregation Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Gestational age at birth (maternal effect) ( 28877031) Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494) Preterm birth (maternal effect) ( 28877031)	Chronic lymphocytic leukemia ( 24292274 28165464 23770605) Clostridioides difficle infection ( 33841421) Cuneus cortex volume ( 31530798) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Lymphocyte percentage of white cells ( 32888494) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Pericalcarine cortex volume ( 31530798) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Systemic sclerosis ( 31672989)
Interacting Genes		5 interacting genes: APP ATXN2 FILNC1 OGT SNCA
Entrez ID		5358	10077
HPRD ID		02133	04834
Ensembl ID		ENSG00000102024	ENSG00000064201
Uniprot IDs		B4DPW9 P13797	Q96QS1
PDB IDs		1AOA 1WJO 7R94 7SX8 7SX9 7SXA
Enriched GO Terms of Interacting Partners?		Growth Cone Amyloid-beta Complex Regulation Of Synapse Assembly Growth Cone Lamellipodium Regulation Of Presynapse Organization Response To Copper Ion Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Neuron Differentiation Regulation Of Presynapse Assembly Regulation Of Protein Catabolic Process Amyloid Fibril Formation Regulation Of Neurotransmitter Uptake Microglial Cell Activation Regulation Of Generation Of Precursor Metabolites And Energy Leukocyte Activation Involved In Inflammatory Response Cellular Response To Copper Ion Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cysteine-type Endopeptidase Inhibitor Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Neuron Differentiation	Structural Constituent Of Presynaptic Actin Cytoskeleton Presynaptic Cytoskeleton Organization Presynaptic Actin Cytoskeleton Organization Actin Filament Network Formation Actin Filament Bundle Regulation Of Synaptic Vesicle Cycle Actin Filament Neuromuscular Junction Bone Development Actin Filament Bundle Assembly Actin Filament Bundle Organization Actin Filament Binding Actin Filament Organization
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