PLS3

Name	plastin 3
Structure
Novel Interactors	14 novel interactors: ACRV1 ASGR1 CUL4B CXCR5 FRYL LRCH2 NRSN1 PTPN5 TGIF2 TRPC5 TSPAN32 WFDC2 ZBTB33 ZNF195
Interactors	5 interactors: APP ATXN2 FILNC1 OGT SNCA
GO Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Plasma Membrane Neuromuscular Junction Actin Filament Bundle
	Molecular Function	Actin Binding Calcium Ion Binding Metal Ion Binding Actin Filament Binding Structural Constituent Of Presynaptic Actin Cytoskeleton
	Biological Process	Actin Filament Bundle Assembly Actin Filament Network Formation Bone Development Regulation Of Synaptic Vesicle Cycle Presynaptic Actin Cytoskeleton Organization
GWAS	Gestational age at birth (maternal effect) ( 28877031 ) Mean platelet volume ( 32888494 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 ) Preterm birth (maternal effect) ( 28877031 )
Entrez ID	5358
HPRD ID	02133
Ensembl ID	ENSG00000102024
Uniprot IDs	B4DPW9 P13797
PDB IDs	1AOA 1WJO 7R94 7SX8 7SX9 7SXA
GO Terms Enriched among Interactors ?	Growth Cone Amyloid-beta Complex Regulation Of Synapse Assembly Growth Cone Lamellipodium Regulation Of Presynapse Organization Response To Copper Ion Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Neuron Differentiation Regulation Of Presynapse Assembly Regulation Of Protein Catabolic Process Amyloid Fibril Formation Regulation Of Neurotransmitter Uptake Microglial Cell Activation Regulation Of Generation Of Precursor Metabolites And Energy Leukocyte Activation Involved In Inflammatory Response Cellular Response To Copper Ion Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cysteine-type Endopeptidase Inhibitor Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Neuron Differentiation