SFPQ and LAMTOR5

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		SFPQ	LAMTOR5
Description		splicing factor proline and glutamine rich	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Matrix Nuclear Speck Dendrite Paraspeckles RNA Polymerase II Transcription Regulator Complex	Cytoplasm Lysosome Lysosomal Membrane Cytosol Late Endosome Membrane Protein-containing Complex Ragulator Complex FNIP-folliculin RagC/D GAP
	Molecular Function	Transcription Cis-regulatory Region Binding Nucleic Acid Binding DNA Binding Chromatin Binding RNA Binding Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Alternative MRNA Splicing, Via Spliceosome Double-strand Break Repair Via Homologous Recombination Activation Of Innate Immune Response Immune System Process DNA Repair DNA Recombination Chromatin Remodeling Regulation Of DNA-templated Transcription MRNA Processing DNA Damage Response RNA Splicing Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Innate Immune Response Positive Regulation Of Sister Chromatid Cohesion Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Chromosome Organization Regulation Of Cell Cycle Dendritic Transport Of Messenger Ribonucleoprotein Complex Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Regulation Of Cell Size Response To Virus Positive Regulation Of Gene Expression Viral Genome Replication Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-8 Production TORC1 Signaling Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of TORC1 Signaling
Pathways		PTK6 Regulates Proteins Involved in RNA Processing Suppression of apoptosis	Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs		Copper Artenimol
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Endometrial cancer ( 21499250) Hip circumference ( 28552196)
Interacting Genes		120 interacting genes: APBB1 AR CD2BP2 CEBPA CEP55 CPSF7 CSNK2A1 CTTN DDX17 DMRTB1 ERG ESR1 EXOSC5 EXOSC8 FHL2 FMR1 FUS FXR1 FXR2 GAS7 H3-4 JPT1 KRT31 LAMTOR5 LINC00624 LINC01554 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NONO OGT PIN1 PPARG PRPF40A PSPC1 PTBP1 RAC1 SF1 SF3B4 SIN3A SMAD5 SNRPA SREK1 TCERG1 TFIP11 TOP1 UBC UBE2I VIM WBP4 ZMYM2	63 interacting genes: ACAA2 AKR1C2 ALB ANKRD46 ASGR1 BHMT C9 CD74 CEP126 CEP70 CFB CLIC5 DBI DNAJA3 ECT2 EEF1A1 EIF3A EIF4B GAPDH GIT1 GIT2 GPRASP1 HEBP2 HSPA9 ITGB1 KEAP1 KIF1B KMT2E LRIF1 MAF1 MCPH1 MED12L MEOX2 MKLN1 MT2A MYF6 MYH3 MYOG NCOA6 PDK1 PEG10 PPARA RABIF RBP4 SERPINA1 SFPQ SHB SKP1 SMAD4 SNX5 TAF9 TBC1D4 TCAP TCF12 TGFB1 TOP2B TP53 TRIM55 TRIM63 UTP14A YTHDC1 ZBTB16 ZNF592
Entrez ID		6421	10542
HPRD ID		07284	09773
Ensembl ID		ENSG00000116560	ENSG00000134248
Uniprot IDs		A0A384N5Z8 P23246 Q86VG2	A0A8Z5A536 O43504
PDB IDs		4WII 4WIJ 4WIK 5WPA 6NCQ 6OWJ 6WMZ 7LRQ 7LRU 7PU5 7SP0 7UJ1 7UK1	3MS6 3MSH 5VOK 5X6U 5X6V 5Y38 5Y39 5Y3A 5YK3 5YK5 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Gene Expression Extracellular Vesicle Negative Regulation Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility Regulation Of Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Locomotion Regulation Of MRNA Stability Positive Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Negative Regulation Of Angiogenesis Negative Regulation Of Cytokine Production Negative Regulation Of Vasculature Development Regulation Of Translation Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Angiogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Endothelial Cell Migration Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Developmental Process	Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Animal Organ Development Negative Regulation Of Glycolytic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Glucose Metabolic Process Muscle Organ Development Regulation Of Skeletal Muscle Tissue Development Regulation Of Carbohydrate Catabolic Process Negative Regulation Of ATP Metabolic Process Disordered Domain Specific Binding Cell Activation Centrosome Striated Muscle Tissue Development RNA Polymerase II Transcription Regulator Complex Regulation Of Nucleobase-containing Compound Metabolic Process Response To Muscle Activity Muscle Structure Development Muscle Tissue Morphogenesis Negative Regulation Of Growth Regulation Of MiRNA Transcription Protein Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Small Molecule Metabolic Process Leukocyte Activation Positive Regulation Of RNA Metabolic Process Muscle Tissue Development Regulation Of Purine Nucleotide Metabolic Process Striated Muscle Atrophy Regulation Of Muscle Cell Differentiation Lymphocyte Activation Lymphocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of DNA-templated Transcription Hexose Metabolic Process Protein-containing Complex Binding Germ Cell Migration Regulation Of MiRNA Metabolic Process Anterior/posterior Pattern Specification Positive Regulation Of Skeletal Muscle Fiber Development Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Sarcomere Organization Regulation Of Striated Muscle Tissue Development Muscle Atrophy Heart Development Identical Protein Binding
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