SFPQ and FUS

Number of citations of the paper that reports this interaction (PMID 15975576)
10

Data Source:
HPRD (in vivo)

		SFPQ	FUS
Gene Name		splicing factor proline/glutamine-rich	FUS RNA binding protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Paraspeckles	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Nucleotide Binding Transcription Regulatory Region Sequence-specific DNA Binding Core Promoter Binding Protein Binding Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding	Nucleotide Binding DNA Binding RNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Alternative MRNA Splicing, Via Spliceosome DNA Repair DNA Recombination Transcription, DNA-templated MRNA Processing RNA Splicing Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Rhythmic Process Histone H3 Deacetylation Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression
Pathways			Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Endometrial cancer ( 21499250)
Protein-Protein Interactions		27 interactors: APBB1 AR CSNK2A1 ERG EXOSC5 FHL2 FUS GAS7 HIST3H3 HN1 NONO PIN1 PPARG PPP1CA PRPF40A PSPC1 PTBP1 RAC1 SIN3A SMAD5 SNRPA SREK1 TCERG1 TOP1 UBC WBP4 ZMYM2	39 interactors: ATXN1L CTNNB1 ESRRA EWSR1 GRIN1 GRIN2D IL7R ILF3 KHDRBS3 MAX MDH1 NKD2 NUPR1 PA2G4 POLR2A PRMT1 PSMB7 PTBP1 RBMX RELA RXRA SAFB2 SF1 SFPQ SPI1 SRRM1 SRSF10 SRSF2 SRSF4 SRSF9 SUV39H1 TAF15 TARDBP TDRD3 THRA TNIP1 WBP4 YBX1 ZMYM2
Entrez ID		6421	2521
HPRD ID		07284	00660
Ensembl ID		ENSG00000116560	ENSG00000089280
Uniprot IDs		P23246 Q86VG2	P35637 Q13344 Q6IBQ5
PDB IDs			2LA6 2LCW 4FDD 4FQ3
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Rhythmic Process Regulation Of Circadian Rhythm RNA Splicing MRNA Metabolic Process Transcription, DNA-templated MRNA Processing RNA Biosynthetic Process Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Apoptotic Process RNA Processing Regulation Of Cell Death Cellular Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Circadian Rhythm Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Regulation Of Transcription, DNA-templated Intracellular Receptor Signaling Pathway Negative Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cell Cycle Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Biosynthetic Process	Gene Expression Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Macromolecule Biosynthetic Process RNA Splicing Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process MRNA Processing Transcription From RNA Polymerase II Promoter Biosynthetic Process MRNA Metabolic Process Regulation Of Transcription, DNA-templated RNA Processing Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Splicing Positive Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Splicing Regulation Of Cellular Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Transcription, DNA-templated MRNA Export From Nucleus RNA Export From Nucleus Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter
Tagcloud ?			antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed
Tagcloud (Difference) ?			antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed
Tagcloud (Intersection) ?