SFPQ and SNRPA

Number of citations of the paper that reports this interaction (PMID 17507659)
24

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		SFPQ	SNRPA
Gene Name		splicing factor proline/glutamine-rich	small nuclear ribonucleoprotein polypeptide A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Paraspeckles	Nucleoplasm Spliceosomal Complex U1 SnRNP Nucleolus Cytoplasm
	Molecular Function	Nucleotide Binding Transcription Regulatory Region Sequence-specific DNA Binding Core Promoter Binding Protein Binding Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding	Nucleotide Binding RNA Binding Protein Binding SnRNA Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Alternative MRNA Splicing, Via Spliceosome DNA Repair DNA Recombination Transcription, DNA-templated MRNA Processing RNA Splicing Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Rhythmic Process Histone H3 Deacetylation Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression
Pathways			Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Endometrial cancer ( 21499250)
Protein-Protein Interactions		27 interactors: APBB1 AR CSNK2A1 ERG EXOSC5 FHL2 FUS GAS7 HIST3H3 HN1 NONO PIN1 PPARG PPP1CA PRPF40A PSPC1 PTBP1 RAC1 SIN3A SMAD5 SNRPA SREK1 TCERG1 TOP1 UBC WBP4 ZMYM2	27 interactors: C19orf43 CDKN2A CIRBP ENOX2 GABPB1 HNRNPK IL7R LENG8 METTL13 MTUS2 NDUFAF3 PAPOLA PCBP1 PCBP2 PTBP1 PTBP2 QKI RBM3 RBM42 RBMX SFPQ SMAD5 SNRPA1 TRIM27 U2AF2 UBC WBP4
Entrez ID		6421	6626
HPRD ID		07284	01658
Ensembl ID		ENSG00000116560	ENSG00000077312
Uniprot IDs		P23246 Q86VG2	B4DDC7 P09012
PDB IDs			1AUD 1CX0 1DRZ 1DZ5 1FHT 1M5K 1M5O 1M5P 1M5V 1NU4 1OIA 1SJ3 1SJ4 1SJF 1U6B 1URN 1VBX 1VBY 1VBZ 1VC0 1VC5 1VC6 1VC7 1ZZN 2A3J 2NZ4 2OIH 2OJ3 2U1A 3BO2 3BO3 3BO4 3CUL 3CUN 3EGZ 3G8S 3G8T 3G96 3G9C 3HHN 3IIN 3IRW 3IWN 3K0J 3L3C 3MUM 3MUR 3MUT 3MUV 3MXH 3P49 3PGW 3R1H 3R1L 3UCU 3UCZ 3UD3 3UD4 3UTR
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Rhythmic Process Regulation Of Circadian Rhythm RNA Splicing MRNA Metabolic Process Transcription, DNA-templated MRNA Processing RNA Biosynthetic Process Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Apoptotic Process RNA Processing Regulation Of Cell Death Cellular Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Circadian Rhythm Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Regulation Of Transcription, DNA-templated Intracellular Receptor Signaling Pathway Negative Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cell Cycle Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Biosynthetic Process	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing RNA Processing MRNA Processing MRNA Metabolic Process Negative Regulation Of RNA Splicing RNA Metabolic Process Gene Expression Negative Regulation Of MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Regulation Of MRNA Processing Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immune System Process Positive Regulation Of Cellular Metabolic Process Protein K63-linked Ubiquitination Positive Regulation Of RNA Splicing Negative Regulation Of Adaptive Immune Response Protein Polyubiquitination Termination Of RNA Polymerase II Transcription Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Type I Interferon Production Biosynthetic Process Ultradian Rhythm Negative Regulation Of Cytokine Production Cellular Metabolic Process Regulation Of MRNA Stability
Tagcloud ?			adh1c aldh6a1 aldob apom ces1 fads1 ftl glo1 hemopexin hnrpdl loc644587 lrrc28 methylglyoxal orosomucoid pabpc1 pla2g10 polr2k rpl14 rpl41 rpl8 rps17 rps24 rps5 srp9 ssh subtractive underexpressed zbtb11 zip14
Tagcloud (Difference) ?			adh1c aldh6a1 aldob apom ces1 fads1 ftl glo1 hemopexin hnrpdl loc644587 lrrc28 methylglyoxal orosomucoid pabpc1 pla2g10 polr2k rpl14 rpl41 rpl8 rps17 rps24 rps5 srp9 ssh subtractive underexpressed zbtb11 zip14
Tagcloud (Intersection) ?