SFPQ and LINC00624

Number of citations: 50 (PubMedID 36252997)
Data Source: BioGRID (unspecified method)

		SFPQ	LINC00624
Name		splicing factor proline and glutamine rich	long intergenic non-protein coding RNA 624
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Matrix Nuclear Speck Dendrite Paraspeckles RNA Polymerase II Transcription Regulator Complex	None
	Molecular Function	Transcription Cis-regulatory Region Binding Nucleic Acid Binding DNA Binding Chromatin Binding RNA Binding Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding	None
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Alternative MRNA Splicing, Via Spliceosome Double-strand Break Repair Via Homologous Recombination Activation Of Innate Immune Response Immune System Process DNA Repair DNA Recombination Chromatin Remodeling Regulation Of DNA-templated Transcription MRNA Processing DNA Damage Response RNA Splicing Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Innate Immune Response Positive Regulation Of Sister Chromatid Cohesion Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Chromosome Organization Regulation Of Cell Cycle Dendritic Transport Of Messenger Ribonucleoprotein Complex Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	None
Pathways		PTK6 Regulates Proteins Involved in RNA Processing Suppression of apoptosis	None
Drugs		Copper Artenimol	None
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Endometrial cancer ( 21499250 ) Hip circumference ( 28552196 )	Body mass index and systolic blood pressure (bivariate analysis) ( 33539483 ) End-stage kidney disease ( 31178898 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) Height ( 31562340 ) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483 ) Waist circumference adjusted for body mass index ( 28552196 )
Interacting Genes		120 interacting genes: APBB1 AR CD2BP2 CEBPA CEP55 CPSF7 CSNK2A1 CTTN DDX17 DMRTB1 ERG ESR1 EXOSC5 EXOSC8 FHL2 FMR1 FUS FXR1 FXR2 GAS7 H3-4 JPT1 KRT31 LAMTOR5 LINC00624 LINC01554 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NONO OGT PIN1 PPARG PRPF40A PSPC1 PTBP1 RAC1 SF1 SF3B4 SIN3A SMAD5 SNRPA SREK1 TCERG1 TFIP11 TOP1 UBC UBE2I VIM WBP4 ZMYM2	38 interacting genes: ACTA1 ACTC1 ADAR ALB CCT2 CCT4 CPNE3 DDX42 DDX5 EIF2AK2 FUBP3 G6PD H2BC18 HDAC6 HNRNPL HNRNPM HNRNPU HRNR ILF3 MCCC1 MCCC2 NONO PARP1 PTBP1 PTBP2 PTBP3 SERBP1 SFPQ SND1 SRRT STAU1 STAU2 TRIM28 TUBA1B TUBA1C UBAP2L YBX3 ZNF354C
Entrez ID		6421	100289211
HPRD ID		07284	Not available
Ensembl ID		ENSG00000116560	ENSG00000278811
Uniprot IDs		A0A384N5Z8 P23246 Q86VG2	Not available
PDB IDs		4WII 4WIJ 4WIK 5WPA 6NCQ 6OWJ 6WMZ 7LRQ 7LRU 7PU5 7SP0 7UJ1 7UK1	Not available
GO Terms Enriched among Interactors		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Gene Expression Extracellular Vesicle Negative Regulation Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility Regulation Of Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Locomotion Regulation Of MRNA Stability Positive Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Negative Regulation Of Angiogenesis Negative Regulation Of Cytokine Production Negative Regulation Of Vasculature Development Regulation Of Translation Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Angiogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of MRNA Metabolic Process Regulation Of Vasculature Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Endothelial Cell Migration Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Developmental Process	RNA Binding RNA Localization Nucleic Acid Binding Double-stranded RNA Binding MRNA Processing MRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Viral Genome Replication Negative Regulation Of Metabolic Process Dendritic Transport Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression RNA Splicing Regulation Of Viral Life Cycle RNA Processing Cytoskeleton-dependent Intracellular Transport Alternative MRNA Splicing, Via Spliceosome Regulation Of Viral Process RNA Metabolic Process Cell Body Nucleus Axo-dendritic Transport Paraspeckles Regulation Of Macromolecule Biosynthetic Process Intracellular MRNA Localization Extracellular Exosome Regulation Of RNA Splicing Methylcrotonoyl-CoA Carboxylase Complex Methylcrotonoyl-CoA Carboxylase Activity Regulation Of Telomere Maintenance Via Telomere Lengthening Pre-mRNA Binding Cytoplasm Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Dendritic Transport Of Messenger Ribonucleoprotein Complex Anterograde Dendritic Transport Of Messenger Ribonucleoprotein Complex Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Response To Chemical Stress Negative Regulation Of RNA Splicing Negative Regulation Of RNA Metabolic Process Regulatory NcRNA-mediated Gene Silencing Transport Along Microtubule Binding Of Sperm To Zona Pellucida Mesenchyme Migration ScaRNA Localization To Cajal Body