IRF1

Description		interferon regulatory factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Immune System Process Regulation Of Adaptive Immune Response Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Interferon-beta CD8-positive, Alpha-beta T Cell Differentiation Innate Immune Response Regulation Of Innate Immune Response Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Regulation Of Cell Cycle Type II Interferon-mediated Signaling Pathway Cellular Response To Mechanical Stimulus Regulation Of CD8-positive, Alpha-beta T Cell Proliferation
Pathways		Pyroptosis Interferon gamma signaling Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Asthma ( 29273806 30929738 31619474 31959851) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433) Asthma (sex interaction) ( 24824216) Asthma or allergic disease (pleiotropy) ( 29785011) C-reactive protein levels ( 21300955) Carotid plaque maximum area ( 32469969) Crohn's disease ( 28067908 21102463) Crohn's disease or systemic sclerosis ( 32024964) Diastolic blood pressure ( 27841878) Fibrinogen ( 20031577 20031576 23969696) Inflammatory bowel disease ( 28067908 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Maximum stenosis ( 32469969) Mean area of carotid plaque ( 32469969) Mean degree of stenosis ( 32469969) Platelet count ( 22139419 32888494) Plateletcrit ( 27863252 32888494) Polycystic ovary syndrome ( 30566500) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum of carotid plaque area ( 32469969) Systemic lupus erythematosus ( 33272962) Type 1 diabetes ( 34012112) Ulcerative colitis ( 28067908)
Novel Interacting Genes		1 novel interacting genes: IL3
Interacting Genes		23 interacting genes: CDKN1B CREBBP DCAF1 EP300 GSK3B HMGA1 IRF8 IRF9 KAT2A KAT2B KEAP1 MDM2 NFKB1 NPM1 QARS1 RELA SET SPI1 SPOP STAT1 TRAF3 TRIM28 YBX1
Entrez ID		3659
HPRD ID		00961
Ensembl ID		ENSG00000125347
Uniprot IDs		A0A7P0TAL6 P10914 Q6FHN8 X5D3F6
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation DNA-binding Transcription Factor Binding Chromatin Organization Chromatin Remodeling Transcription Coactivator Binding Acetyltransferase Activity Transcription Coregulator Activity Positive Regulation Of Gene Expression Regulation Of Cellular Response To Stress Response To Stress Histone Acetyltransferase Complex Protein-containing Complex Protein-lysine-acetyltransferase Activity Cellular Response To Cytokine Stimulus Transcription Coactivator Activity Histone Acetyltransferase Activity NF-kappaB Binding
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