SELL and VCAN

Number of citations: 0 (PubMedID 10950950)
Data Source: BioGRID (pull down)

		SELL	VCAN
Name		selectin L	versican
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane	Photoreceptor Outer Segment Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Membrane Extracellular Matrix Interphotoreceptor Matrix Cell Projection Lysosomal Lumen Synapse Perineuronal Net
	Molecular Function	Protease Binding Calcium Ion Binding Protein Binding Heparin Binding Carbohydrate Binding Sialic Acid Binding Glycosphingolipid Binding Metal Ion Binding Oligosaccharide Binding	Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Hyaluronic Acid Binding Protein Tyrosine Phosphatase Activator Activity Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding
	Biological Process	Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Cytokine Leukocyte Migration Leukocyte Tethering Or Rolling Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules	Skeletal System Development Osteoblast Differentiation Cell Adhesion Central Nervous System Development Cell Recognition Glial Cell Migration System Development
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Neutrophil degranulation	Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation
Drugs		None	Hyaluronic acid
Diseases		None	Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
GWAS		Acne (severe) ( 24399259 ) Amyotrophic lateral sclerosis ( 19451621 ) Basophil percentage of white cells ( 32888494 ) Blood protein levels ( 30072576 ) Eosinophil percentage of white cells ( 32888494 ) Inflammatory bowel disease ( 26192919 ) L-selectin levels ( 25576479 ) Monocyte count ( 32888494 )	Appendicular lean mass ( 33097823 28724990 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (MOSTest) ( 32665545 ) Carotid intima media thickness (mean) ( 31801372 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical volume ( 32963231 ) Diisocyanate-induced asthma ( 25918132 ) Gastroesophageal reflux disease ( 31527586 ) HDL cholesterol levels ( 32203549 ) Joint mobility (Beighton score) ( 27182965 ) Laryngeal squamous cell carcinoma ( 25194280 ) Lean body mass ( 28724990 ) Major depressive disorder ( 20516156 ) Optic disc size ( 31809533 ) Subcortical volume (MOSTest) ( 32665545 ) Triglyceride levels ( 32203549 ) Vertical cup-disc ratio ( 28073927 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) White matter hyperintensity volume ( 29752348 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 ) White matter integrity (fractional anisotropy) ( 29752348 32358547 ) White matter integrity (mean diffusivity) ( 29752348 32358547 )
Interacting Genes		16 interacting genes: CD4 CFH EMCN EZR GRB2 MSN MUC7 PODXL PODXL2 PRKCA PRKCQ PRKG1 SELE SELPLG SLC30A2 VCAN	24 interacting genes: ADAMTS1 CCL2 CCL20 CCL21 CCL5 CCL8 CD44 CXCL10 CXCL12 FBLN1 FBLN2 FBN1 HAPLN1 ITGA4 ITGB1 PF4 PLA2G2A PTPRF RAB19 SELL SELP SELPLG TNR XCL1
Entrez ID		6402	1462
HPRD ID		07034	00340
Ensembl ID		ENSG00000188404	ENSG00000038427
Uniprot IDs		P14151	P13611 Q59FG9 Q86W61
PDB IDs		2LGF 3CFW 5VC1	Not available
GO Terms Enriched among Interactors		Leukocyte Cell-cell Adhesion Cell Adhesion Regulation Of Cell-cell Adhesion Uropod Plasma Membrane Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Microvillus Membrane Regulation Of Platelet Aggregation Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Cell Migration Membrane To Membrane Docking Positive Regulation Of Cell-cell Adhesion Regulation Of Platelet Activation Cell Motility Regulation Of Interleukin-2 Production Positive Regulation Of Early Endosome To Late Endosome Transport Microvillus Regulation Of Immune System Process Positive Regulation Of Protein Localization To Early Endosome Filopodium Positive Regulation Of Protein Localization To Endosome Cell-cell Adhesion Positive Regulation Of Leukocyte Cell-cell Adhesion Immune System Process Golgi Lumen Establishment Of Epithelial Cell Apical/basal Polarity Diacylglycerol-dependent Serine/threonine Kinase Activity Leukocyte Activation Regulation Of Early Endosome To Late Endosome Transport T Cell Activation Establishment Of Apical/basal Cell Polarity Positive Regulation Of Immune System Process Regulation Of Cell Activation Glycosaminoglycan Binding Epithelial Cell Development Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Cell Activation Cortical Cytoskeleton Gland Morphogenesis Establishment Of Epithelial Cell Polarity Regulation Of Leukocyte Cell-cell Adhesion Signaling Receptor Binding Actin Filament-based Process Plasma Membrane Raft Positive Regulation Of Interleukin-2 Production Establishment Of Endothelial Barrier	Leukocyte Migration Chemokine Activity Cell Migration Cell Motility Positive Regulation Of Leukocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of T Cell Migration Regulation Of Lymphocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Lymphocyte Migration Positive Regulation Of Locomotion Regulation Of Leukocyte Migration Regulation Of T Cell Migration Antimicrobial Humoral Response Positive Regulation Of Mononuclear Cell Migration Cell Adhesion Leukocyte Cell-cell Adhesion Mononuclear Cell Migration Inflammatory Response Extracellular Space Regulation Of Cell Migration Killing Of Cells Of Another Organism Cell Chemotaxis Cytokine Activity Regulation Of Cell Motility Granulocyte Chemotaxis Leukocyte Chemotaxis Chemokine-mediated Signaling Pathway Regulation Of Locomotion Regulation Of Mononuclear Cell Migration Heparin Binding Granulocyte Migration Humoral Immune Response Extracellular Region Leukocyte Tethering Or Rolling Cell Killing Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Lymphocyte Chemotaxis Regulation Of Cell Adhesion CCR Chemokine Receptor Binding Chemotaxis Myeloid Leukocyte Migration Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Locomotion Chemokine Receptor Binding Regulation Of Leukocyte Cell-cell Adhesion Response To Cytokine Response To Peptide