SELL and SELPLG

Number of citations of the paper that reports this interaction (PubMedID 10725346)
40

Data Source:
HPRD (in vitro, in vivo)

		SELL	SELPLG
Description		selectin L	selectin P ligand
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane	Uropod Plasma Membrane Membrane Plasma Membrane Raft
	Molecular Function	Protease Binding Calcium Ion Binding Protein Binding Heparin Binding Carbohydrate Binding Sialic Acid Binding Glycosphingolipid Binding Metal Ion Binding Oligosaccharide Binding	Virus Receptor Activity Signaling Receptor Binding Protein Binding
	Biological Process	Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Cytokine Leukocyte Migration Leukocyte Tethering Or Rolling Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules	Cell Adhesion Symbiont Entry Into Host Cell Leukocyte Migration Leukocyte Tethering Or Rolling Leukocyte Adhesive Activation Cellular Response To Interleukin-6
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Neutrophil degranulation	Cell surface interactions at the vascular wall
Drugs			Neihulizumab
Diseases
GWAS		Acne (severe) ( 24399259) Amyotrophic lateral sclerosis ( 19451621) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 26192919) L-selectin levels ( 25576479) Monocyte count ( 32888494)	Acne (severe) ( 24927181) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Conduct disorder (symptom count) ( 20585324)
Interacting Genes		16 interacting genes: CD4 CFH EMCN EZR GRB2 MSN MUC7 PODXL PODXL2 PRKCA PRKCQ PRKG1 SELE SELPLG SLC30A2 VCAN	14 interacting genes: BACE1 CTSG GALNT4 MAGEA1 MSN SELE SELL SELP SLC13A1 SYK TNIP1 TPST1 TPST2 VCAN
Entrez ID		6402	6404
HPRD ID		07034	02845
Ensembl ID		ENSG00000188404	ENSG00000110876
Uniprot IDs		P14151	Q14242
PDB IDs		2LGF 3CFW 5VC1	1G1S
Enriched GO Terms of Interacting Partners?		Leukocyte Cell-cell Adhesion Cell Adhesion Regulation Of Cell-cell Adhesion Uropod Plasma Membrane Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Microvillus Membrane Regulation Of Platelet Aggregation Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Cell Migration Membrane To Membrane Docking Positive Regulation Of Cell-cell Adhesion Regulation Of Platelet Activation Cell Motility Regulation Of Interleukin-2 Production Positive Regulation Of Early Endosome To Late Endosome Transport Microvillus Regulation Of Immune System Process Positive Regulation Of Protein Localization To Early Endosome Filopodium Positive Regulation Of Protein Localization To Endosome Cell-cell Adhesion Positive Regulation Of Leukocyte Cell-cell Adhesion Immune System Process Golgi Lumen Establishment Of Epithelial Cell Apical/basal Polarity Diacylglycerol-dependent Serine/threonine Kinase Activity Leukocyte Activation Regulation Of Early Endosome To Late Endosome Transport T Cell Activation Establishment Of Apical/basal Cell Polarity Positive Regulation Of Immune System Process Regulation Of Cell Activation Glycosaminoglycan Binding Epithelial Cell Development Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Cell Activation Cortical Cytoskeleton Gland Morphogenesis Establishment Of Epithelial Cell Polarity Regulation Of Leukocyte Cell-cell Adhesion Signaling Receptor Binding Actin Filament-based Process Plasma Membrane Raft Positive Regulation Of Interleukin-2 Production Establishment Of Endothelial Barrier	Leukocyte Cell-cell Adhesion Leukocyte Migration Oligosaccharide Binding Carbohydrate Binding Leukocyte Tethering Or Rolling Sialic Acid Binding Protein-tyrosine Sulfotransferase Activity Leukocyte Adhesion To Vascular Endothelial Cell Cell-cell Adhesion Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Glycosphingolipid Binding Regulation Of Platelet Activation Cell Motility Positive Regulation Of Leukocyte Tethering Or Rolling Regulation Of Leukocyte Tethering Or Rolling 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Golgi Lumen Response To Lipopolysaccharide Immune System Process Phospholipase Binding Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Response To Molecule Of Bacterial Origin Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Neutrophil Activation Positive Regulation Of Receptor Internalization Regulation Of Platelet Aggregation Regulation Of Leukocyte Cell-cell Adhesion Heparin Binding Regulation Of Immune System Process Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cellular Extravasation Pattern Recognition Receptor Signaling Pathway Regulation Of Inflammatory Response Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Innate Immune Response-activating Signaling Pathway Trans-Golgi Network Signaling Receptor Ligand Precursor Processing Response To Lipid Biofilm Matrix Disassembly Regulation Of Defense Response Mevalonate Kinase Activity Interleukin-15 Receptor Binding Positive Regulation Of Interleukin-3 Production Peptidyl-tyrosine Sulfation Golgi-associated Vesicle Lumen Activation Of Innate Immune Response Response To External Biotic Stimulus
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