SELL and CFH

Number of citations of the paper that reports this interaction (PMID 10377245)
7

Data Source:
HPRD (in vitro)

		SELL	CFH
Gene Name		selectin L	complement factor H
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Extracellular Region Extracellular Space Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protease Binding Protein Binding Heparin Binding Carbohydrate Binding Glycosphingolipid Binding Cell Adhesion Molecule Binding	Protein Binding Heparin Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Cell Adhesion Blood Coagulation Response To ATP Regulation Of Immune Response Leukocyte Migration	Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation Innate Immune Response
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Adaptive Immune System	Regulation of Complement cascade Complement cascade Innate Immune System
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 19451621)	Age-related macular degeneration ( 20385819 20385826 22694956 23326517 23577725 23455636 23536807 20861866 21665990 15761122) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (GA) ( 22705344) Circulating myeloperoxidase levels (serum) ( 23620142) Complement C3 and C4 levels ( 23028341) Meningococcal disease ( 20694013) Nephropathy ( 21399633)
Protein-Protein Interactions		15 interactors: CD4 CFH EMCN EZR GRB2 MSN MUC7 PODXL PODXL2 PRKCA PRKCQ PRKG1 SELE SELPLG VCAN	16 interactors: ADM C3 CFHR1 CFI CRP DMP1 EP300 GRB2 ITGAM PTX3 SELL SMAD3 THBS1 VDR YTHDC1 ZBTB16
Entrez ID		6402	3075
HPRD ID		07034	00601
Ensembl ID		ENSG00000188404	ENSG00000000971
Uniprot IDs		P14151	F8WDX4 P08603
PDB IDs		1KJB 2LGF 3CFW	1FHC 1HAQ 1HCC 1HFH 1HFI 1KOV 2BZM 2G7I 2IC4 2JGW 2JGX 2KMS 2QFG 2QFH 2RLP 2RLQ 2UWN 2V8E 2W80 2W81 2WII 2XQW 3GAU 3GAV 3GAW 3KXV 3KZJ 3OXU 3R62 3RJ3 3SW0 4AYD 4AYE 4AYI 4AYM 4B2R 4B2S 4J38
Enriched GO Terms of Interacting Partners?		Locomotion Movement Of Cell Or Subcellular Component Leukocyte Migration Cell Migration Cell Motility Cell Adhesion Leukocyte Cell-cell Adhesion Immune System Process Regulation Of Cell-cell Adhesion Leukocyte Tethering Or Rolling Blood Coagulation Hemostasis Regulation Of Platelet Aggregation Single Organismal Cell-cell Adhesion Regulation Of Body Fluid Levels Cellular Extravasation Wound Healing Regulation Of Platelet Activation Regulation Of Cell Adhesion Response To Wounding Positive Regulation Of Cell Adhesion Membrane To Membrane Docking Regulation Of Immune System Process Regulation Of Cell Activation Positive Regulation Of Immune System Process Positive Regulation Of Cell-cell Adhesion Cell Differentiation Regulation Of Blood Coagulation Cell Activation Positive Regulation Of Interleukin-2 Biosynthetic Process Regulation Of Wound Healing Defense Response Innate Immune Response Cellular Response To Radiation Regulation Of Interleukin-2 Biosynthetic Process Regulation Of Rhodopsin Mediated Signaling Pathway Establishment Of Endothelial Barrier Rhodopsin Mediated Signaling Pathway Platelet Activation Positive Regulation Of Interleukin-2 Production Positive Regulation Of T Cell Activation Epithelial Cell Development Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Response To Stress Receptor Internalization Regulation Of Cell Migration Chemotaxis Cell Development Response To External Stimulus	Immune System Process Immune Response Regulation Of Immune System Process Tissue Development Regulation Of Immune Response Positive Regulation Of Immune System Process Response To Wounding Positive Regulation Of Reactive Oxygen Species Metabolic Process Defense Response Positive Regulation Of Cellular Metabolic Process Response To Hypoxia Response To Stress Wound Healing Complement Activation Positive Regulation Of Immune Response Endocytosis Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Cell Adhesion Organ Development Protein Activation Cascade Inflammatory Response Response To External Stimulus System Development Innate Immune Response Positive Regulation Of Metabolic Process Humoral Immune Response Response To Organic Cyclic Compound Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Cytokine Production Opsonization Phagocytosis Regulation Of Body Fluid Levels Organ Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Gene Expression Multicellular Organismal Development Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cell Adhesion Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Development Epithelium Development Response To Abiotic Stimulus Negative Regulation Of Cell Proliferation Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-substrate Adhesion Anatomical Structure Morphogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Cytokine Production Complement Activation, Classical Pathway
Tagcloud ?		aw cereal cereals consignments contents corrected damaged dry heterogeneity ill infestation insects inspection kernels mould overseas portion prompt safe shipments shipped storage substance substantiated substituted theoretical trade usefully validity	bands blue carcinoscorpius concerted converted crab crabs denaturation detoxification dosage fatalities fluorescent haemolymph horseshoe intracardially ld50 neutralization neutralizing page proteinaceous reacted rotundicauda sds spot tetrodotoxin tlc ttx wts yellow
Tagcloud (Difference) ?		aw cereal cereals consignments contents corrected damaged dry heterogeneity ill infestation insects inspection kernels mould overseas portion prompt safe shipments shipped storage substance substantiated substituted theoretical trade usefully validity	bands blue carcinoscorpius concerted converted crab crabs denaturation detoxification dosage fatalities fluorescent haemolymph horseshoe intracardially ld50 neutralization neutralizing page proteinaceous reacted rotundicauda sds spot tetrodotoxin tlc ttx wts yellow
Tagcloud (Intersection) ?