CCL11 and ACKR4

Number of citations of the paper that reports this interaction (PubMedID 10734104)
0

Data Source:
HPRD (in vitro)

		CCL11	ACKR4
Description		C-C motif chemokine ligand 11	atypical chemokine receptor 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Endosome Early Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Recycling Endosome
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding Protein Dimerization Activity Receptor Ligand Activity CCR Chemokine Receptor Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity Scavenger Receptor Activity Protein Binding C-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Chronic Inflammatory Response Mast Cell Chemotaxis Protein Phosphorylation Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Actin Filament Organization Cell Adhesion Signal Transduction Learning Or Memory Regulation Of Cell Shape Response To Radiation Response To Virus Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Killing Of Cells Of Another Organism Response To Interleukin-13 Positive Regulation Of Angiogenesis Eosinophil Chemotaxis Negative Regulation Of Neurogenesis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway ERK1 And ERK2 Cascade Response To Interleukin-4	Chemotaxis Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Vesicle-mediated Transport Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines Interleukin-4 and Interleukin-13 signaling	Chemokine receptors bind chemokines
Drugs		CAT-213
Diseases
GWAS		Crohn's disease ( 22412388 28067908) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 23128233 28067908) Triglyceride levels in HIV infection ( 33109212)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		29 interacting genes: ACKR2 ACKR4 CCL13 CCL14 CCL18 CCL2 CCL26 CCL27 CCL28 CCL5 CCL8 CCR3 CCR5 CXCL1 CXCL10 CXCL11 CXCL12 CXCL14 CXCL2 CXCL3 CXCL5 CXCL6 CXCL9 DPP4 NUDT3 PF4 PF4V1 TPI1 XCL1	11 interacting genes: CCL11 CCL13 CCL19 CCL2 CCL21 CCL25 CCL5 CCL7 CCL8 CDK2 CXCL13
Entrez ID		6356	51554
HPRD ID		03098	07298
Ensembl ID		ENSG00000172156	ENSG00000129048
Uniprot IDs		P51671 Q6I9T4	Q9NPB9
PDB IDs		1EOT 2EOT 2MPM 7SCS
Enriched GO Terms of Interacting Partners?		Chemokine Activity Cell Chemotaxis Chemotaxis Locomotion Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cytokine Activity Humoral Immune Response Chemokine-mediated Signaling Pathway Cell Migration Leukocyte Chemotaxis Cell Motility Inflammatory Response Granulocyte Chemotaxis Granulocyte Migration Immune Response Leukocyte Migration Defense Response Killing Of Cells Of Another Organism Myeloid Leukocyte Migration Defense Response To Symbiont Defense Response To Other Organism Immune System Process CXCR Chemokine Receptor Binding Cytokine-mediated Signaling Pathway Cell Killing Response To External Biotic Stimulus Response To Other Organism Extracellular Space G Protein-coupled Receptor Signaling Pathway Neutrophil Chemotaxis Neutrophil Migration CCR Chemokine Receptor Binding Response To Stress Extracellular Region Cell-cell Signaling Signaling Cell Communication Mononuclear Cell Migration Cellular Response To Lipopolysaccharide Signal Transduction Cellular Response To Molecule Of Bacterial Origin Chemokine Receptor Binding Response To Molecule Of Bacterial Origin CXCR3 Chemokine Receptor Binding Response To Lipopolysaccharide Cell Surface Receptor Signaling Pathway Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of Calcium Ion Transport	Eosinophil Migration Eosinophil Chemotaxis Chemokine Activity CCR Chemokine Receptor Binding Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Granulocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Myeloid Leukocyte Migration Leukocyte Chemotaxis Antimicrobial Humoral Response Cell Chemotaxis Cytokine Activity Leukocyte Migration Humoral Immune Response Chemotaxis Locomotion Cytokine-mediated Signaling Pathway Inflammatory Response Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Leukocyte Migration Defense Response To Symbiont Defense Response To Other Organism Killing Of Cells Of Another Organism G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Leukocyte Migration Cell Migration Regulation Of Lymphocyte Chemotaxis Regulation Of Cell Migration Cell Killing Regulation Of Cell Motility Cell Motility Regulation Of Locomotion Positive Regulation Of Leukocyte Chemotaxis Response To Other Organism Chemokine Receptor Binding Mononuclear Cell Migration Immune Response Response To External Biotic Stimulus Defense Response Positive Regulation Of Chemotaxis CCR10 Chemokine Receptor Binding Extracellular Space Positive Regulation Of Lymphocyte Chemotaxis Regulation Of Lymphocyte Migration Intracellular Calcium Ion Homeostasis Regulation Of Chemotaxis Calcium Ion Homeostasis
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