ACKR4 and CCL19

Number of citations of the paper that reports this interaction (PMID 10706668)
23

Data Source:
HPRD (in vitro)

		ACKR4	CCL19
Gene Name		atypical chemokine receptor 4	chemokine (C-C motif) ligand 19
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Recycling Endosome	Extracellular Region Extracellular Space
	Molecular Function	Chemokine Receptor Activity Scavenger Receptor Activity Protein Binding Chemokine Binding	Chemokine Activity CCR7 Chemokine Receptor Binding CCR10 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	Receptor-mediated Endocytosis Chemotaxis Immune Response G-protein Coupled Receptor Signaling Pathway Chemokine-mediated Signaling Pathway	Establishment Of T Cell Polarity Immunological Synapse Formation Dendritic Cell Chemotaxis Myeloid Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Cellular Calcium Ion Homeostasis Inflammatory Response Immune Response Cell Communication Activation Of JUN Kinase Activity Response To Virus Positive Regulation Of Glycoprotein Biosynthetic Process T Cell Costimulation Positive Regulation Of Ras GTPase Activity Positive Regulation Of Interleukin-12 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Prostaglandin E Positive Regulation Of T Cell Proliferation Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Cdc42 GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Endocytosis Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Protein Kinase B Signaling Regulation Of Cell Projection Assembly Positive Regulation Of ERK1 And ERK2 Cascade Response To Nitric Oxide Interleukin-12 Secretion Positive Regulation Of Neutrophil Chemotaxis Mature Conventional Dendritic Cell Differentiation Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Cell Motility Positive Regulation Of Dendritic Cell Dendrite Assembly
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CCL11 CCL13 CCL19 CCL2 CCL21 CCL25 CCL5 CCL7 CCL8 CDK2 CXCL13	6 interactors: ACKR2 ACKR4 CCL22 CCR10 CCR7 CXCL13
Entrez ID		51554	6363
HPRD ID		07298	03750
Ensembl ID		ENSG00000129048	ENSG00000172724
Uniprot IDs		Q9NPB9	Q6IBD6 Q99731
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Leukocyte Chemotaxis Leukocyte Migration Inflammatory Response Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Chemotaxis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Regulation Of Leukocyte Migration Cellular Ion Homeostasis Metal Ion Homeostasis Cell Migration Cell Motility Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Leukocyte Chemotaxis Cellular Homeostasis Positive Regulation Of Leukocyte Migration Regulation Of Lymphocyte Migration Locomotion Eosinophil Chemotaxis Immune Response Eosinophil Migration Defense Response Positive Regulation Of Chemotaxis Chemical Homeostasis Positive Regulation Of Behavior Movement Of Cell Or Subcellular Component Regulation Of Chemotaxis Regulation Of Cell Migration Positive Regulation Of Cell Migration Granulocyte Chemotaxis Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Locomotion Response To External Stimulus Regulation Of Cellular Component Movement Regulation Of Behavior Homeostatic Process Immune System Process Response To Stress Regulation Of Granulocyte Chemotaxis Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Dendritic Cell Chemotaxis Monocyte Chemotaxis Positive Regulation Of Cell-cell Adhesion	Chemokine-mediated Signaling Pathway Chemotaxis Inflammatory Response Cytokine-mediated Signaling Pathway Locomotion Immune Response Cellular Response To Cytokine Stimulus Response To Cytokine Response To External Stimulus Immune System Process G-protein Coupled Receptor Signaling Pathway Defense Response Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Chemotaxis Cytosolic Calcium Ion Homeostasis Neutrophil Activation Cellular Response To Organic Substance Lymphocyte Migration Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Humoral Immune Response Receptor-mediated Endocytosis Response To Organic Substance Activation Of Ras GTPase Activity Cellular Metal Ion Homeostasis Positive Regulation Of Leukocyte Chemotaxis Cellular Cation Homeostasis Signal Transduction Cellular Ion Homeostasis Metal Ion Homeostasis Leukocyte Activation Signaling Positive Regulation Of Leukocyte Migration Cell Communication Cellular Chemical Homeostasis Cell Surface Receptor Signaling Pathway Ion Homeostasis Chemokine (C-C Motif) Ligand 21 Signaling Pathway Chemokine (C-C Motif) Ligand 19 Signaling Pathway Lymphocyte Chemotaxis Across High Endothelial Venule Positive Regulation Of Immunological Synapse Formation Endothelial Cell Chemotaxis To Fibroblast Growth Factor B Cell Chemotaxis Across High Endothelial Venule Positive Regulation Of Glycoprotein Biosynthetic Process Involved In Immunological Synapse Formation Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Lymphocyte Migration Into Lymph Node Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Response To Stress
Tagcloud ?			aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl20 ccl21 chemokine chemokines chemotaxis conditioned contributors converted cryosections cxcl13 cxcl16 evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger
Tagcloud (Difference) ?			aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl20 ccl21 chemokine chemokines chemotaxis conditioned contributors converted cryosections cxcl13 cxcl16 evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger
Tagcloud (Intersection) ?