ACKR4 and CCL19

Number of citations of the paper that reports this interaction (PubMedID 10706668)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		ACKR4	CCL19
Description		atypical chemokine receptor 4	C-C motif chemokine ligand 19
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Early Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Recycling Endosome	Extracellular Region Extracellular Space
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Scavenger Receptor Activity Protein Binding C-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding	Cytokine Activity Protein Binding Chemokine Activity CCR7 Chemokine Receptor Binding CCR10 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	Chemotaxis Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Vesicle-mediated Transport Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway	Establishment Of T Cell Polarity Immunological Synapse Formation Dendritic Cell Chemotaxis Myeloid Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cell Communication Response To Virus Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Cell Migration T Cell Costimulation Killing Of Cells Of Another Organism Regulation Of Cdc42 Protein Signal Transduction Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Rac Protein Signal Transduction CCL19-activated CCR7 Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Endocytosis Positive Regulation Of JNK Cascade Eosinophil Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Projection Assembly Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Prostaglandin E Stimulus Response To Nitric Oxide Positive Regulation Of Neutrophil Chemotaxis Mature Conventional Dendritic Cell Differentiation Cellular Response To Virus Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		Chemokine receptors bind chemokines	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Subcortical volume (MOSTest) ( 32665545)	Metabolite levels ( 23823483) Rheumatoid arthritis ( 24390342 30423114)
Interacting Genes		11 interacting genes: CCL11 CCL13 CCL19 CCL2 CCL21 CCL25 CCL5 CCL7 CCL8 CDK2 CXCL13	8 interacting genes: ACKR2 ACKR4 CCL22 CCR10 CCR7 CXCL13 MEOX2 PF4V1
Entrez ID		51554	6363
HPRD ID		07298	03750
Ensembl ID		ENSG00000129048	ENSG00000172724
Uniprot IDs		Q9NPB9	Q6IBD6 Q99731
PDB IDs			2MP1 7STA
Enriched GO Terms of Interacting Partners?		Eosinophil Migration Eosinophil Chemotaxis Chemokine Activity CCR Chemokine Receptor Binding Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Granulocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Myeloid Leukocyte Migration Leukocyte Chemotaxis Antimicrobial Humoral Response Cell Chemotaxis Cytokine Activity Leukocyte Migration Humoral Immune Response Chemotaxis Locomotion Cytokine-mediated Signaling Pathway Inflammatory Response Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Leukocyte Migration Defense Response To Symbiont Defense Response To Other Organism Killing Of Cells Of Another Organism G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Leukocyte Migration Cell Migration Regulation Of Lymphocyte Chemotaxis Regulation Of Cell Migration Cell Killing Regulation Of Cell Motility Cell Motility Regulation Of Locomotion Positive Regulation Of Leukocyte Chemotaxis Response To Other Organism Chemokine Receptor Binding Mononuclear Cell Migration Immune Response Response To External Biotic Stimulus Defense Response Positive Regulation Of Chemotaxis CCR10 Chemokine Receptor Binding Extracellular Space Positive Regulation Of Lymphocyte Chemotaxis Regulation Of Lymphocyte Migration Intracellular Calcium Ion Homeostasis Regulation Of Chemotaxis Calcium Ion Homeostasis	Chemokine-mediated Signaling Pathway Cell Chemotaxis C-C Chemokine Receptor Activity Chemokine Receptor Activity Chemotaxis Locomotion Cytokine-mediated Signaling Pathway Myeloid Leukocyte Migration Positive Regulation Of Cytosolic Calcium Ion Concentration External Side Of Plasma Membrane Cell Migration C-C Chemokine Binding Leukocyte Migration Immune System Process Cell Motility G Protein-coupled Receptor Signaling Pathway Leukocyte Chemotaxis Inflammatory Response Chemokine Activity Calcium-mediated Signaling G Protein-coupled Receptor Activity Galactose Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Granulocyte Chemotaxis Cell Surface Receptor Signaling Pathway CXCR Chemokine Receptor Binding Cellular Response To Lipid Granulocyte Migration Immune Response Mononuclear Cell Migration Response To Lipopolysaccharide Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Response To Molecule Of Bacterial Origin Antimicrobial Humoral Response C-C Motif Chemokine 19 Receptor Activity Chemokine (C-C Motif) Ligand 19 Binding Positive Regulation Of Glycoprotein Biosynthetic Process Involved In Immunological Synapse Formation Chemokine (C-C Motif) Ligand 21 Binding C-C Motif Chemokine 21 Receptor Activity UDP-glucose:hexose-1-phosphate Uridylyltransferase Activity Positive Regulation Of Circulating Fibrinogen Levels Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Negative Regulation Of Ectodermal Cell Fate Specification CXCR5 Chemokine Receptor Binding Lymphocyte Chemotaxis Across High Endothelial Venule Endothelial Cell Chemotaxis To Fibroblast Growth Factor Response To Lipid Regulation Of Humoral Immune Response Signal Transduction
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