CCL11 and NUDT3

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		CCL11	NUDT3
Gene Name		chemokine (C-C motif) ligand 11	nudix (nucleoside diphosphate linked moiety X)-type motif 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Chemokine Activity	Magnesium Ion Binding Diphosphoinositol-polyphosphate Diphosphatase Activity Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate Diphosphatase Activity Inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate Diphosphatase Activity Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase Activity Inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Chronic Inflammatory Response Mast Cell Chemotaxis Protein Phosphorylation Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Actin Filament Organization Cell Adhesion Signal Transduction Regulation Of Cell Shape Response To Radiation Response To Virus Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Rac GTPase Activity Positive Regulation Of Angiogenesis Eosinophil Chemotaxis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth ERK1 And ERK2 Cascade Response To Interleukin-4	Cell-cell Signaling Diadenosine Polyphosphate Catabolic Process Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Diphosphoinositol Polyphosphate Catabolic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Synthesis of pyrophosphates in the cytosol Inositol phosphate metabolism
Drugs
Diseases
GWAS		Crohn's disease ( 22412388) Inflammatory bowel disease ( 23128233)	Body mass index ( 20935630) Height ( 19893584)
Protein-Protein Interactions		7 interactors: ACKR2 ACKR4 CCR3 CCR5 DPP4 NUDT3 TPI1	36 interactors: ALAS1 APEX1 ARL6IP1 ASB13 CCL11 CHCHD3 DBN1 DDR1 DNAJA1 EEF1G FXYD3 HES1 ITFG1 MAF1 MCM5 MEX3B NR2C1 NUDT5 OAT PDCD5 PEX5 PRKD3 RAB17 REEP5 RNF126 RPL17 RPL8 RPLP1 SOX30 TNNT3 TUBA1A TUBGCP4 UBR1 VPS51 WDR74 XPNPEP1
Entrez ID		6356	11165
HPRD ID		03098	14849
Ensembl ID		ENSG00000172156
Uniprot IDs		P51671 Q6I9T4	O95989
PDB IDs		1EOT 2EOT	2FVV 2Q9P
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Locomotion Cellular Response To Cytokine Stimulus Chemotaxis Response To Cytokine Cellular Defense Response G-protein Coupled Receptor Signaling Pathway Inflammatory Response Diphosphoinositol Polyphosphate Catabolic Process Diadenosine Polyphosphate Catabolic Process Organophosphate Catabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Response To External Stimulus Cellular Response To Organic Substance Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Cytosolic Calcium Ion Homeostasis Immune System Process Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cell-cell Adhesion Mediated By Integrin Cellular Calcium Ion Homeostasis Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Homeostasis Response To Organic Substance Dendritic Cell Chemotaxis Receptor-mediated Endocytosis Immune Response Defense Response Cellular Metal Ion Homeostasis Neutrophil Activation Cellular Cation Homeostasis Response To Cholesterol Cellular Ion Homeostasis Dendritic Cell Migration Pentose-phosphate Shunt Glyceraldehyde-3-phosphate Metabolic Process Cell Surface Receptor Signaling Pathway Metal Ion Homeostasis Leukocyte Activation Regulation Of Extracellular Matrix Disassembly Cellular Chemical Homeostasis Signaling Viral Process Response To Stress Glucose 6-phosphate Metabolic Process Release Of Sequestered Calcium Ion Into Cytosol Ion Homeostasis Cell Communication Nucleotide Metabolic Process	Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Establishment Of Protein Localization To Membrane Cellular Metabolic Process Protein Targeting Intracellular Transport Protein Localization To Organelle Cellular Localization Cellular Protein Localization Translational Elongation Establishment Of Protein Localization To Organelle Catabolic Process Protein Localization To Membrane Protein Localization Intracellular Protein Transport Viral Transcription Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Cellular Process Establishment Of Localization In Cell Protein Targeting To ER Cytoplasmic Transport Aromatic Compound Catabolic Process Establishment Of Protein Localization To Endoplasmic Reticulum Protein Transport Protein Localization To Endoplasmic Reticulum DNA Strand Elongation Involved In DNA Replication Establishment Of Protein Localization Branching Involved In Mammary Gland Duct Morphogenesis DNA Strand Elongation Translational Termination Membrane Organization Cellular Macromolecule Catabolic Process Nuclear-transcribed MRNA Catabolic Process Metabolic Process MRNA Catabolic Process Transcription Factor TFIIIB Complex Assembly Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Cytoplasm-associated Proteasomal Ubiquitin-dependent Protein Catabolic Process Pharyngeal Arch Artery Morphogenesis Lateral Inhibition Positive Regulation Of Protein Import Into Mitochondrial Outer Membrane Negative Regulation Of Chaperone-mediated Protein Folding Mammary Gland Duct Morphogenesis RNA Catabolic Process Cellular Nitrogen Compound Metabolic Process Response To Interleukin-4 Cellular Protein Complex Disassembly Viral Life Cycle
Tagcloud ?		biopsy ccl5 cells chemokines chemotaxins compare cx3cl1 determined distribution epithelial il immunohistochemistry included intraepithelial investigate mast method might migrate migration mucosa nasal normal objective obtained polyps regulated result specimens
Tagcloud (Difference) ?		biopsy ccl5 cells chemokines chemotaxins compare cx3cl1 determined distribution epithelial il immunohistochemistry included intraepithelial investigate mast method might migrate migration mucosa nasal normal objective obtained polyps regulated result specimens
Tagcloud (Intersection) ?