CCL11 and CCR5

Number of citations of the paper that reports this interaction (PMID 10477718)
47

Data Source:
HPRD (in vitro, in vivo)

		CCL11	CCR5
Gene Name		chemokine (C-C motif) ligand 11	chemokine (C-C motif) receptor 5 (gene/pseudogene)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface
	Molecular Function	Protein Binding Chemokine Activity	Actin Binding Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Chronic Inflammatory Response Mast Cell Chemotaxis Protein Phosphorylation Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Actin Filament Organization Cell Adhesion Signal Transduction Regulation Of Cell Shape Response To Radiation Response To Virus Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Rac GTPase Activity Positive Regulation Of Angiogenesis Eosinophil Chemotaxis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth ERK1 And ERK2 Cascade Response To Interleukin-4	MAPK Cascade Dendritic Cell Chemotaxis Calcium Ion Transport Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Viral Process Calcium-mediated Signaling Signaling Entry Into Host Cell Chemokine-mediated Signaling Pathway Response To Cholesterol Cellular Response To Lipopolysaccharide
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR HIV Infection Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Early Phase of HIV Life Cycle GPCR downstream signaling HIV Life Cycle Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events Binding and entry of HIV virion
Drugs			Maraviroc
Diseases
GWAS		Crohn's disease ( 22412388) Inflammatory bowel disease ( 23128233)	Celiac disease ( 20190752)
Protein-Protein Interactions		7 interactors: ACKR2 ACKR4 CCR3 CCR5 DPP4 NUDT3 TPI1	41 interactors: ADRBK1 ADRBK2 AFP ARL6IP5 ARRB1 CCL11 CCL13 CCL14 CCL16 CCL2 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCL8 CD4 CST9L CTBP2 CXCR4 DNM2 ETV5 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ IL24 JAK1 JAK2 LCK ORM1 PRAF2 PSMA5 PTK2 PTK2B STAT1 STAT3 STAT5A TXK
Entrez ID		6356	1234
HPRD ID		03098	03223
Ensembl ID		ENSG00000172156	ENSG00000160791
Uniprot IDs		P51671 Q6I9T4	A0A502 P51681 Q38L21
PDB IDs		1EOT 2EOT	1ND8 1NE0 1OPN 1OPT 1OPW 2L87 2RLL 2RRS 4MBS
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Locomotion Cellular Response To Cytokine Stimulus Chemotaxis Response To Cytokine Cellular Defense Response G-protein Coupled Receptor Signaling Pathway Inflammatory Response Diphosphoinositol Polyphosphate Catabolic Process Diadenosine Polyphosphate Catabolic Process Organophosphate Catabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Response To External Stimulus Cellular Response To Organic Substance Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Cytosolic Calcium Ion Homeostasis Immune System Process Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cell-cell Adhesion Mediated By Integrin Cellular Calcium Ion Homeostasis Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Homeostasis Response To Organic Substance Dendritic Cell Chemotaxis Receptor-mediated Endocytosis Immune Response Defense Response Cellular Metal Ion Homeostasis Neutrophil Activation Cellular Cation Homeostasis Response To Cholesterol Cellular Ion Homeostasis Dendritic Cell Migration Pentose-phosphate Shunt Glyceraldehyde-3-phosphate Metabolic Process Cell Surface Receptor Signaling Pathway Metal Ion Homeostasis Leukocyte Activation Regulation Of Extracellular Matrix Disassembly Cellular Chemical Homeostasis Signaling Viral Process Response To Stress Glucose 6-phosphate Metabolic Process Release Of Sequestered Calcium Ion Into Cytosol Ion Homeostasis Cell Communication Nucleotide Metabolic Process	Response To Stress Cell Chemotaxis Defense Response Immune Response Immune System Process Cellular Response To Stimulus Inflammatory Response Cell Migration Cell Motility Response To Stimulus Response To External Stimulus Signaling Locomotion Cell Communication Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Signal Transduction Regulation Of Cell Proliferation Chemotaxis Movement Of Cell Or Subcellular Component Positive Regulation Of Metabolic Process Eosinophil Chemotaxis Eosinophil Migration Cellular Metal Ion Homeostasis Cell Activation Cellular Cation Homeostasis Positive Regulation Of Signal Transduction Regulation Of Lymphocyte Migration Cellular Ion Homeostasis Metal Ion Homeostasis Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Natural Killer Cell Chemotaxis Cellular Chemical Homeostasis Regulation Of Signal Transduction Regulation Of Signaling Chemical Homeostasis Response To Cytokine Ion Homeostasis Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Growth Hormone Receptor Signaling Pathway Leukocyte Chemotaxis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Granulocyte Chemotaxis Cellular Response To Growth Hormone Stimulus
Tagcloud ?		biopsy ccl5 cells chemokines chemotaxins compare cx3cl1 determined distribution epithelial il immunohistochemistry included intraepithelial investigate mast method might migrate migration mucosa nasal normal objective obtained polyps regulated result specimens	7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Difference) ?		biopsy ccl5 cells chemotaxins compare cx3cl1 determined distribution epithelial il immunohistochemistry included intraepithelial investigate mast method might migration mucosa nasal normal objective obtained polyps regulated result specimens	7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 chemokine chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Intersection) ?		chemokines migrate