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ACKR4 and CCL8
Number of citations of the paper that reports this interaction (PMID
10734104
)
12
Data Source:
HPRD
(in vitro)
ACKR4
CCL8
Gene Name
atypical chemokine receptor 4
chemokine (C-C motif) ligand 8
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Early Endosome
Plasma Membrane
Integral Component Of Plasma Membrane
Recycling Endosome
Extracellular Space
Molecular Function
Chemokine Receptor Activity
Scavenger Receptor Activity
Protein Binding
Chemokine Binding
Protein Kinase Activity
Chemokine Activity
Heparin Binding
Phospholipase Activator Activity
Biological Process
Receptor-mediated Endocytosis
Chemotaxis
Immune Response
G-protein Coupled Receptor Signaling Pathway
Chemokine-mediated Signaling Pathway
Protein Phosphorylation
Calcium Ion Transport
Cellular Calcium Ion Homeostasis
Exocytosis
Chemotaxis
Inflammatory Response
Immune Response
Signal Transduction
Cell-cell Signaling
Response To Virus
Positive Regulation Of Catalytic Activity
Cell Chemotaxis
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
Peptide ligand-binding receptors
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
Metabolic disorders of biological oxidation enzymes
GPCR ligand binding
Drugs
Diseases
GWAS
Crohn's disease (
22412388
)
Protein-Protein Interactions
11 interactors:
CCL11
CCL13
CCL19
CCL2
CCL21
CCL25
CCL5
CCL7
CCL8
CDK2
CXCL13
8 interactors:
ACKR1
ACKR2
ACKR4
CCR1
CCR3
CCR5
MMP3
VCAN
Entrez ID
51554
6355
HPRD ID
07298
03791
Ensembl ID
ENSG00000129048
ENSG00000108700
Uniprot IDs
Q9NPB9
P80075
PDB IDs
1ESR
Enriched GO Terms of Interacting Partners
?
Cell Chemotaxis
Leukocyte Chemotaxis
Leukocyte Migration
Inflammatory Response
Cellular Calcium Ion Homeostasis
Calcium Ion Homeostasis
Chemotaxis
Cellular Metal Ion Homeostasis
Cellular Cation Homeostasis
Regulation Of Leukocyte Migration
Cellular Ion Homeostasis
Metal Ion Homeostasis
Cell Migration
Cell Motility
Cellular Chemical Homeostasis
Ion Homeostasis
Positive Regulation Of Leukocyte Chemotaxis
Cellular Homeostasis
Positive Regulation Of Leukocyte Migration
Regulation Of Lymphocyte Migration
Locomotion
Eosinophil Chemotaxis
Immune Response
Eosinophil Migration
Defense Response
Positive Regulation Of Chemotaxis
Chemical Homeostasis
Positive Regulation Of Behavior
Movement Of Cell Or Subcellular Component
Regulation Of Chemotaxis
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Granulocyte Chemotaxis
Positive Regulation Of Cell Motility
Regulation Of Cell Motility
Positive Regulation Of Cellular Component Movement
Positive Regulation Of Locomotion
Regulation Of Locomotion
Response To External Stimulus
Regulation Of Cellular Component Movement
Regulation Of Behavior
Homeostatic Process
Immune System Process
Response To Stress
Regulation Of Granulocyte Chemotaxis
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Dendritic Cell Chemotaxis
Monocyte Chemotaxis
Positive Regulation Of Cell-cell Adhesion
Chemokine-mediated Signaling Pathway
Cytokine-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
Response To Cytokine
Inflammatory Response
Cellular Response To Organic Substance
G-protein Coupled Receptor Signaling Pathway
Chemotaxis
Locomotion
Response To Organic Substance
Dendritic Cell Chemotaxis
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cytosolic Calcium Ion Homeostasis
Defense Response
Dendritic Cell Migration
Cellular Calcium Ion Homeostasis
Calcium Ion Homeostasis
Cell Surface Receptor Signaling Pathway
Response To External Stimulus
Cellular Defense Response
Response To Stress
Cellular Metal Ion Homeostasis
Cellular Cation Homeostasis
Cellular Ion Homeostasis
Metal Ion Homeostasis
Immune Response
Leukocyte Chemotaxis
Cellular Chemical Homeostasis
Ion Homeostasis
Cellular Response To Stimulus
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Cellular Homeostasis
Negative Regulation Of Hydrogen Peroxide Metabolic Process
Cell Chemotaxis
Signal Transduction
Cell Migration
Chemical Homeostasis
Leukocyte Migration
Positive Regulation Of Oxidative Stress-induced Cell Death
Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Cell Motility
Signaling
Response To Stimulus
Regulation Of Hydrogen Peroxide Metabolic Process
Cell Communication
Immune System Process
Positive Regulation Of Monocyte Chemotaxis
Sarcoplasmic Reticulum Calcium Ion Transport
Dermatan Sulfate Biosynthetic Process
Dermatan Sulfate Proteoglycan Biosynthetic Process
Tagcloud
?
3kda
attenuation
blockage
cd44
chemokines
conclusively
conversely
cxcl1
cxcl2
cxcl6
dermal
fibroblasts
granulation
ha
healing
hmw
hyaluronan
leukocytes
lmw
mediators
mw
nhdf
players
pro
stromal
supernatants
tendency
transferred
wound
Tagcloud (Difference)
?
3kda
attenuation
blockage
cd44
chemokines
conclusively
conversely
cxcl1
cxcl2
cxcl6
dermal
fibroblasts
granulation
ha
healing
hmw
hyaluronan
leukocytes
lmw
mediators
mw
nhdf
players
pro
stromal
supernatants
tendency
transferred
wound
Tagcloud (Intersection)
?