CCL11 and CXCL1

Number of citations of the paper that reports this interaction (PubMedID 28381538)
0

Data Source:
BioGRID (pull down)

		CCL11	CXCL1
Description		C-C motif chemokine ligand 11	C-X-C motif chemokine ligand 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Specific Granule Lumen Tertiary Granule Lumen
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding Protein Dimerization Activity Receptor Ligand Activity CCR Chemokine Receptor Binding	Signaling Receptor Binding Cytokine Activity Protein Binding Chemokine Activity Enzyme Activator Activity Growth Factor Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Chronic Inflammatory Response Mast Cell Chemotaxis Protein Phosphorylation Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Actin Filament Organization Cell Adhesion Signal Transduction Learning Or Memory Regulation Of Cell Shape Response To Radiation Response To Virus Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Killing Of Cells Of Another Organism Response To Interleukin-13 Positive Regulation Of Angiogenesis Eosinophil Chemotaxis Negative Regulation Of Neurogenesis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway ERK1 And ERK2 Cascade Response To Interleukin-4	Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Nervous System Development Negative Regulation Of Cell Population Proliferation Actin Cytoskeleton Organization Killing Of Cells Of Another Organism Intracellular Signal Transduction Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Chemokine receptors bind chemokines Interleukin-4 and Interleukin-13 signaling	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling Neutrophil degranulation
Drugs		CAT-213
Diseases
GWAS		Crohn's disease ( 22412388 28067908) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 23128233 28067908) Triglyceride levels in HIV infection ( 33109212)	Anxiety disorder ( 25390645) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Growth-regulated protein alpha levels ( 27989323) Inflammatory bowel disease ( 23128233)
Interacting Genes		29 interacting genes: ACKR2 ACKR4 CCL13 CCL14 CCL18 CCL2 CCL26 CCL27 CCL28 CCL5 CCL8 CCR3 CCR5 CXCL1 CXCL10 CXCL11 CXCL12 CXCL14 CXCL2 CXCL3 CXCL5 CXCL6 CXCL9 DPP4 NUDT3 PF4 PF4V1 TPI1 XCL1	13 interacting genes: ACKR1 CCL11 CXCL5 CXCL6 CXCR1 CXCR2 ESR1 HIPK2 HRAS MEOX2 MMP9 PTEN XRCC3
Entrez ID		6356	2919
HPRD ID		03098	01119
Ensembl ID		ENSG00000172156	ENSG00000163739
Uniprot IDs		P51671 Q6I9T4	P09341
PDB IDs		1EOT 2EOT 2MPM 7SCS	1MGS 1MSG 1MSH 1ROD 8K4O 8XWA 8XWV
Enriched GO Terms of Interacting Partners?		Chemokine Activity Cell Chemotaxis Chemotaxis Locomotion Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cytokine Activity Humoral Immune Response Chemokine-mediated Signaling Pathway Cell Migration Leukocyte Chemotaxis Cell Motility Inflammatory Response Granulocyte Chemotaxis Granulocyte Migration Immune Response Leukocyte Migration Defense Response Killing Of Cells Of Another Organism Myeloid Leukocyte Migration Defense Response To Symbiont Defense Response To Other Organism Immune System Process CXCR Chemokine Receptor Binding Cytokine-mediated Signaling Pathway Cell Killing Response To External Biotic Stimulus Response To Other Organism Extracellular Space G Protein-coupled Receptor Signaling Pathway Neutrophil Chemotaxis Neutrophil Migration CCR Chemokine Receptor Binding Response To Stress Extracellular Region Cell-cell Signaling Signaling Cell Communication Mononuclear Cell Migration Cellular Response To Lipopolysaccharide Signal Transduction Cellular Response To Molecule Of Bacterial Origin Chemokine Receptor Binding Response To Molecule Of Bacterial Origin CXCR3 Chemokine Receptor Binding Response To Lipopolysaccharide Cell Surface Receptor Signaling Pathway Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of Calcium Ion Transport	Chemokine-mediated Signaling Pathway Granulocyte Chemotaxis Granulocyte Migration Myeloid Leukocyte Migration Positive Regulation Of Cell Population Proliferation Chemotaxis Leukocyte Chemotaxis Neutrophil Chemotaxis Locomotion Neutrophil Migration Cell Chemotaxis Interleukin-8-mediated Signaling Pathway Leukocyte Migration Interleukin-8 Receptor Activity C-C Chemokine Binding Cell Migration Interleukin-8 Binding Cell Motility Regulation Of Cell Population Proliferation Chemokine Activity Cytokine-mediated Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway C-X-C Chemokine Receptor Activity Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway Inflammatory Response CXCR Chemokine Receptor Binding Dendritic Cell Chemotaxis Response To Stress Branching Involved In Mammary Gland Duct Morphogenesis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Intracellular Signal Transduction Immune Response Chemokine Receptor Activity C-C Chemokine Receptor Activity Dendritic Cell Migration Positive Regulation Of Cytosolic Calcium Ion Concentration Neutrophil Activation Antimicrobial Humoral Response Defense Response Cellular Response To Lipopolysaccharide Negative Regulation Of Apoptotic Process Cellular Response To Lipid Negative Regulation Of Programmed Cell Death Cellular Response To Molecule Of Bacterial Origin Fibroblast Proliferation Cytokine Activity Regulation Of Cell Migration Regulation Of Cell Motility
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