ACKR4 and CCL13

Number of citations of the paper that reports this interaction (PMID 10734104)
12

Data Source:
HPRD (in vitro)

		ACKR4	CCL13
Gene Name		atypical chemokine receptor 4	chemokine (C-C motif) ligand 13
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Recycling Endosome	Extracellular Space
	Molecular Function	Chemokine Receptor Activity Scavenger Receptor Activity Protein Binding Chemokine Binding	Receptor Binding Chemokine Activity
	Biological Process	Receptor-mediated Endocytosis Chemotaxis Immune Response G-protein Coupled Receptor Signaling Pathway Chemokine-mediated Signaling Pathway	Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Signal Transduction Cell-cell Signaling Regulation Of Cell Shape Eosinophil Chemotaxis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Crohn's disease ( 22412388) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		11 interactors: CCL11 CCL13 CCL19 CCL2 CCL21 CCL25 CCL5 CCL7 CCL8 CDK2 CXCL13	8 interactors: ACKR2 ACKR4 APP CCR3 CCR5 HNRNPH3 MMP1 MMP3
Entrez ID		51554	6357
HPRD ID		07298	03230
Ensembl ID		ENSG00000129048	ENSG00000181374
Uniprot IDs		Q9NPB9	Q99616
PDB IDs			2RA4
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Leukocyte Chemotaxis Leukocyte Migration Inflammatory Response Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Chemotaxis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Regulation Of Leukocyte Migration Cellular Ion Homeostasis Metal Ion Homeostasis Cell Migration Cell Motility Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Leukocyte Chemotaxis Cellular Homeostasis Positive Regulation Of Leukocyte Migration Regulation Of Lymphocyte Migration Locomotion Eosinophil Chemotaxis Immune Response Eosinophil Migration Defense Response Positive Regulation Of Chemotaxis Chemical Homeostasis Positive Regulation Of Behavior Movement Of Cell Or Subcellular Component Regulation Of Chemotaxis Regulation Of Cell Migration Positive Regulation Of Cell Migration Granulocyte Chemotaxis Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Locomotion Response To External Stimulus Regulation Of Cellular Component Movement Regulation Of Behavior Homeostatic Process Immune System Process Response To Stress Regulation Of Granulocyte Chemotaxis Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Dendritic Cell Chemotaxis Monocyte Chemotaxis Positive Regulation Of Cell-cell Adhesion	Chemokine-mediated Signaling Pathway Chemotaxis Locomotion Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Oligomerization Cellular Response To Cytokine Stimulus Regulation Of Protein Oligomerization Response To Cytokine Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Response To External Stimulus Cellular Response To Organic Substance Cellular Defense Response Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Response To Stress Cellular Metal Ion Homeostasis Immune System Process Inflammatory Response Collagen Metabolic Process G-protein Coupled Receptor Signaling Pathway Cellular Cation Homeostasis Multicellular Organismal Macromolecule Metabolic Process Cellular Ion Homeostasis Multicellular Organismal Metabolic Process Metal Ion Homeostasis Extracellular Matrix Disassembly Immune Response Response To Organic Substance Cellular Chemical Homeostasis Defense Response Viral Process Synaptic Growth At Neuromuscular Junction Ion Homeostasis Collateral Sprouting In Absence Of Injury Endocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Homeostasis Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Protein Complex Assembly Cell Surface Receptor Signaling Pathway Collateral Sprouting Axon Midline Choice Point Recognition Cytosolic Calcium Ion Homeostasis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Chemical Homeostasis Leukocyte Migration Positive Regulation Of Oxidative Stress-induced Cell Death
Tagcloud ?			3b amylin bead bmi ccl19 ccl2 correction cxcl10 cxcl12 cxcl5 cxcl6 draw ena epidemiologic examining fdr gcp2 inactivity mcp mip multiplex nested obesity ors sdf stnfrii topic twelve vigorous
Tagcloud (Difference) ?			3b amylin bead bmi ccl19 ccl2 correction cxcl10 cxcl12 cxcl5 cxcl6 draw ena epidemiologic examining fdr gcp2 inactivity mcp mip multiplex nested obesity ors sdf stnfrii topic twelve vigorous
Tagcloud (Intersection) ?