CCL11 and CXCL3

Number of citations of the paper that reports this interaction (PubMedID 28381538)
0

Data Source:
BioGRID (pull down)

		CCL11	CXCL3
Description		C-C motif chemokine ligand 11	C-X-C motif chemokine ligand 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding Protein Dimerization Activity Receptor Ligand Activity CCR Chemokine Receptor Binding	Cytokine Activity Chemokine Activity
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Chronic Inflammatory Response Mast Cell Chemotaxis Protein Phosphorylation Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Actin Filament Organization Cell Adhesion Signal Transduction Learning Or Memory Regulation Of Cell Shape Response To Radiation Response To Virus Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Killing Of Cells Of Another Organism Response To Interleukin-13 Positive Regulation Of Angiogenesis Eosinophil Chemotaxis Negative Regulation Of Neurogenesis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway ERK1 And ERK2 Cascade Response To Interleukin-4	Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction Neutrophil Chemotaxis Killing Of Cells Of Another Organism Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Chemokine receptors bind chemokines Interleukin-4 and Interleukin-13 signaling	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		CAT-213
Diseases
GWAS		Crohn's disease ( 22412388 28067908) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 23128233 28067908) Triglyceride levels in HIV infection ( 33109212)	Inflammatory bowel disease ( 23128233) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		29 interacting genes: ACKR2 ACKR4 CCL13 CCL14 CCL18 CCL2 CCL26 CCL27 CCL28 CCL5 CCL8 CCR3 CCR5 CXCL1 CXCL10 CXCL11 CXCL12 CXCL14 CXCL2 CXCL3 CXCL5 CXCL6 CXCL9 DPP4 NUDT3 PF4 PF4V1 TPI1 XCL1	6 interacting genes: CCL11 CXCL5 CXCL6 CXCR1 CXCR2 XCL2
Entrez ID		6356	2921
HPRD ID		03098	00742
Ensembl ID		ENSG00000172156	ENSG00000163734
Uniprot IDs		P51671 Q6I9T4	P19876
PDB IDs		1EOT 2EOT 2MPM 7SCS	8XWF 8XX3
Enriched GO Terms of Interacting Partners?		Chemokine Activity Cell Chemotaxis Chemotaxis Locomotion Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cytokine Activity Humoral Immune Response Chemokine-mediated Signaling Pathway Cell Migration Leukocyte Chemotaxis Cell Motility Inflammatory Response Granulocyte Chemotaxis Granulocyte Migration Immune Response Leukocyte Migration Defense Response Killing Of Cells Of Another Organism Myeloid Leukocyte Migration Defense Response To Symbiont Defense Response To Other Organism Immune System Process CXCR Chemokine Receptor Binding Cytokine-mediated Signaling Pathway Cell Killing Response To External Biotic Stimulus Response To Other Organism Extracellular Space G Protein-coupled Receptor Signaling Pathway Neutrophil Chemotaxis Neutrophil Migration CCR Chemokine Receptor Binding Response To Stress Extracellular Region Cell-cell Signaling Signaling Cell Communication Mononuclear Cell Migration Cellular Response To Lipopolysaccharide Signal Transduction Cellular Response To Molecule Of Bacterial Origin Chemokine Receptor Binding Response To Molecule Of Bacterial Origin CXCR3 Chemokine Receptor Binding Response To Lipopolysaccharide Cell Surface Receptor Signaling Pathway Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of Calcium Ion Transport	Cell Chemotaxis Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Granulocyte Migration Chemotaxis Locomotion Myeloid Leukocyte Migration Leukocyte Chemotaxis Chemokine Activity Neutrophil Chemotaxis Leukocyte Migration Neutrophil Migration Cell Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cytokine-mediated Signaling Pathway Cell Motility Interleukin-8-mediated Signaling Pathway Immune Response Interleukin-8 Receptor Activity Antimicrobial Humoral Response Inflammatory Response Interleukin-8 Binding Cytokine Activity Humoral Immune Response G Protein-coupled Receptor Signaling Pathway Immune System Process C-X-C Chemokine Receptor Activity CXCR Chemokine Receptor Binding Dendritic Cell Chemotaxis Defense Response Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Dendritic Cell Migration CCR Chemokine Receptor Binding Neutrophil Activation Defense Response To Symbiont Defense Response To Other Organism Cell Surface Receptor Signaling Pathway Signal Transduction Response To Other Organism Receptor Internalization Response To External Biotic Stimulus Secretory Granule Membrane Mononuclear Cell Migration Extracellular Space Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Myeloid Leukocyte Activation Response To Stress Mammary Duct Terminal End Bud Growth
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