ACKR4 and CXCL13

Number of citations of the paper that reports this interaction (PMID 10706668)
23

Data Source:
HPRD (in vitro)

		ACKR4	CXCL13
Gene Name		atypical chemokine receptor 4	chemokine (C-X-C motif) ligand 13
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Recycling Endosome	Extracellular Region Extracellular Space
	Molecular Function	Chemokine Receptor Activity Scavenger Receptor Activity Protein Binding Chemokine Binding	Chemokine Activity Heparin Binding Fibroblast Growth Factor Binding CXCR5 Chemokine Receptor Binding CCR10 Chemokine Receptor Binding Protein Heterodimerization Activity Receptor Agonist Activity CXCR3 Chemokine Receptor Binding
	Biological Process	Receptor-mediated Endocytosis Chemotaxis Immune Response G-protein Coupled Receptor Signaling Pathway Chemokine-mediated Signaling Pathway	Germinal Center Formation Lymphocyte Chemotaxis Across High Endothelial Venule Chronic Inflammatory Response Regulation Of Humoral Immune Response Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Positive Regulation Of T Cell Chemotaxis Response To Lipopolysaccharide Activation Of Rap GTPase Activity Positive Regulation Of Integrin Activation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin B Cell Chemotaxis Endothelial Cell Chemotaxis To Fibroblast Growth Factor B Cell Chemotaxis Across High Endothelial Venule Regulation Of Cell Proliferation Defense Response To Bacterium Regulation Of Angiogenesis Lymph Node Development Chemokine-mediated Signaling Pathway Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Cardiac Troponin-T levels ( 23247143)
Protein-Protein Interactions		11 interactors: CCL11 CCL13 CCL19 CCL2 CCL21 CCL25 CCL5 CCL7 CCL8 CDK2 CXCL13	8 interactors: ACKR4 CCL19 CCL21 CCR10 CXCR3 CXCR5 EEF1G FGF2
Entrez ID		51554	10563
HPRD ID		07298	05513
Ensembl ID		ENSG00000129048	ENSG00000156234
Uniprot IDs		Q9NPB9	O43927 Q53X90
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Leukocyte Chemotaxis Leukocyte Migration Inflammatory Response Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Chemotaxis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Regulation Of Leukocyte Migration Cellular Ion Homeostasis Metal Ion Homeostasis Cell Migration Cell Motility Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Leukocyte Chemotaxis Cellular Homeostasis Positive Regulation Of Leukocyte Migration Regulation Of Lymphocyte Migration Locomotion Eosinophil Chemotaxis Immune Response Eosinophil Migration Defense Response Positive Regulation Of Chemotaxis Chemical Homeostasis Positive Regulation Of Behavior Movement Of Cell Or Subcellular Component Regulation Of Chemotaxis Regulation Of Cell Migration Positive Regulation Of Cell Migration Granulocyte Chemotaxis Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Locomotion Response To External Stimulus Regulation Of Cellular Component Movement Regulation Of Behavior Homeostatic Process Immune System Process Response To Stress Regulation Of Granulocyte Chemotaxis Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Dendritic Cell Chemotaxis Monocyte Chemotaxis Positive Regulation Of Cell-cell Adhesion	Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Response To External Stimulus Cytosolic Calcium Ion Homeostasis Chemokine-mediated Signaling Pathway Locomotion Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Chemotaxis Positive Regulation Of Behavior Regulation Of Chemotaxis Cellular Metal Ion Homeostasis Positive Regulation Of Phosphatidylinositol 3-kinase Activity Cellular Cation Homeostasis Cellular Ion Homeostasis Regulation Of Ion Homeostasis Metal Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Sequestering Of Calcium Ion Regulation Of Behavior Regulation Of Dendritic Cell Dendrite Assembly Cellular Chemical Homeostasis Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Ion Homeostasis Immune System Process Regulation Of Phosphatidylinositol 3-kinase Activity Immune Response Regulation Of Lipid Kinase Activity Cellular Homeostasis Response To Organic Substance Establishment Of T Cell Polarity Positive Regulation Of Locomotion Chemical Homeostasis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Leukocyte Chemotaxis Regulation Of Leukocyte Migration Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Dendritic Cell Chemotaxis Positive Regulation Of Glycoprotein Biosynthetic Process Immunological Synapse Formation Leukocyte Activation Positive Regulation Of Glycoprotein Metabolic Process G-protein Coupled Receptor Signaling Pathway Response To Prostaglandin E Cell Chemotaxis Cellular Response To Cytokine Stimulus Regulation Of Cell Migration
Tagcloud ?			aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl19 ccl20 ccl21 chemokine chemokines chemotaxis conditioned contributors converted cryosections evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger
Tagcloud (Difference) ?			aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl19 ccl20 ccl21 chemokine chemokines chemotaxis conditioned contributors converted cryosections evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger
Tagcloud (Intersection) ?