ACKR4 and CCL11

Number of citations of the paper that reports this interaction (PMID 10734104)
12

Data Source:
HPRD (in vitro)

		ACKR4	CCL11
Gene Name		atypical chemokine receptor 4	chemokine (C-C motif) ligand 11
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Recycling Endosome	Extracellular Region Extracellular Space
	Molecular Function	Chemokine Receptor Activity Scavenger Receptor Activity Protein Binding Chemokine Binding	Protein Binding Chemokine Activity
	Biological Process	Receptor-mediated Endocytosis Chemotaxis Immune Response G-protein Coupled Receptor Signaling Pathway Chemokine-mediated Signaling Pathway	Positive Regulation Of Endothelial Cell Proliferation Chronic Inflammatory Response Mast Cell Chemotaxis Protein Phosphorylation Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Actin Filament Organization Cell Adhesion Signal Transduction Regulation Of Cell Shape Response To Radiation Response To Virus Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Rac GTPase Activity Positive Regulation Of Angiogenesis Eosinophil Chemotaxis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth ERK1 And ERK2 Cascade Response To Interleukin-4
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Crohn's disease ( 22412388) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		11 interactors: CCL11 CCL13 CCL19 CCL2 CCL21 CCL25 CCL5 CCL7 CCL8 CDK2 CXCL13	7 interactors: ACKR2 ACKR4 CCR3 CCR5 DPP4 NUDT3 TPI1
Entrez ID		51554	6356
HPRD ID		07298	03098
Ensembl ID		ENSG00000129048	ENSG00000172156
Uniprot IDs		Q9NPB9	P51671 Q6I9T4
PDB IDs			1EOT 2EOT
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Leukocyte Chemotaxis Leukocyte Migration Inflammatory Response Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Chemotaxis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Regulation Of Leukocyte Migration Cellular Ion Homeostasis Metal Ion Homeostasis Cell Migration Cell Motility Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Leukocyte Chemotaxis Cellular Homeostasis Positive Regulation Of Leukocyte Migration Regulation Of Lymphocyte Migration Locomotion Eosinophil Chemotaxis Immune Response Eosinophil Migration Defense Response Positive Regulation Of Chemotaxis Chemical Homeostasis Positive Regulation Of Behavior Movement Of Cell Or Subcellular Component Regulation Of Chemotaxis Regulation Of Cell Migration Positive Regulation Of Cell Migration Granulocyte Chemotaxis Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Locomotion Response To External Stimulus Regulation Of Cellular Component Movement Regulation Of Behavior Homeostatic Process Immune System Process Response To Stress Regulation Of Granulocyte Chemotaxis Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Dendritic Cell Chemotaxis Monocyte Chemotaxis Positive Regulation Of Cell-cell Adhesion	Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Locomotion Cellular Response To Cytokine Stimulus Chemotaxis Response To Cytokine Cellular Defense Response G-protein Coupled Receptor Signaling Pathway Inflammatory Response Diphosphoinositol Polyphosphate Catabolic Process Diadenosine Polyphosphate Catabolic Process Organophosphate Catabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Response To External Stimulus Cellular Response To Organic Substance Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Cytosolic Calcium Ion Homeostasis Immune System Process Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cell-cell Adhesion Mediated By Integrin Cellular Calcium Ion Homeostasis Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Homeostasis Response To Organic Substance Dendritic Cell Chemotaxis Receptor-mediated Endocytosis Immune Response Defense Response Cellular Metal Ion Homeostasis Neutrophil Activation Cellular Cation Homeostasis Response To Cholesterol Cellular Ion Homeostasis Dendritic Cell Migration Pentose-phosphate Shunt Glyceraldehyde-3-phosphate Metabolic Process Cell Surface Receptor Signaling Pathway Metal Ion Homeostasis Leukocyte Activation Regulation Of Extracellular Matrix Disassembly Cellular Chemical Homeostasis Signaling Viral Process Response To Stress Glucose 6-phosphate Metabolic Process Release Of Sequestered Calcium Ion Into Cytosol Ion Homeostasis Cell Communication Nucleotide Metabolic Process
Tagcloud ?			biopsy ccl5 cells chemokines chemotaxins compare cx3cl1 determined distribution epithelial il immunohistochemistry included intraepithelial investigate mast method might migrate migration mucosa nasal normal objective obtained polyps regulated result specimens
Tagcloud (Difference) ?			biopsy ccl5 cells chemokines chemotaxins compare cx3cl1 determined distribution epithelial il immunohistochemistry included intraepithelial investigate mast method might migrate migration mucosa nasal normal objective obtained polyps regulated result specimens
Tagcloud (Intersection) ?