CCL8 and ACKR2

Number of citations of the paper that reports this interaction (PMID 9405404)
30

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		CCL8	ACKR2
Gene Name		chemokine (C-C motif) ligand 8	atypical chemokine receptor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Early Endosome Actin Filament Plasma Membrane Integral Component Of Plasma Membrane Recycling Endosome
	Molecular Function	Protein Kinase Activity Chemokine Activity Heparin Binding Phospholipase Activator Activity	Chemokine Receptor Activity Scavenger Receptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of Catalytic Activity Cell Chemotaxis	Receptor-mediated Endocytosis Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Multicellular Organismal Development Neutrophil Activation Chemokine-mediated Signaling Pathway
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Crohn's disease ( 22412388)
Protein-Protein Interactions		8 interactors: ACKR1 ACKR2 ACKR4 CCR1 CCR3 CCR5 MMP3 VCAN	16 interactors: APP CCL11 CCL13 CCL14 CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL5 CCL7 CCL8
Entrez ID		6355	1238
HPRD ID		03791	09095
Ensembl ID		ENSG00000108700	ENSG00000144648
Uniprot IDs		P80075	O00590
PDB IDs		1ESR
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Inflammatory Response Cellular Response To Organic Substance G-protein Coupled Receptor Signaling Pathway Chemotaxis Locomotion Response To Organic Substance Dendritic Cell Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Defense Response Dendritic Cell Migration Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway Response To External Stimulus Cellular Defense Response Response To Stress Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Immune Response Leukocyte Chemotaxis Cellular Chemical Homeostasis Ion Homeostasis Cellular Response To Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Homeostasis Negative Regulation Of Hydrogen Peroxide Metabolic Process Cell Chemotaxis Signal Transduction Cell Migration Chemical Homeostasis Leukocyte Migration Positive Regulation Of Oxidative Stress-induced Cell Death Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cell Motility Signaling Response To Stimulus Regulation Of Hydrogen Peroxide Metabolic Process Cell Communication Immune System Process Positive Regulation Of Monocyte Chemotaxis Sarcoplasmic Reticulum Calcium Ion Transport Dermatan Sulfate Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process	Cell Chemotaxis Chemotaxis Cell Migration Locomotion Immune Response Cell Motility Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Movement Of Cell Or Subcellular Component Cellular Metal Ion Homeostasis Inflammatory Response Response To External Stimulus Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Leukocyte Migration Cellular Chemical Homeostasis Immune System Process Ion Homeostasis Cellular Homeostasis Leukocyte Chemotaxis Eosinophil Chemotaxis Leukocyte Migration Chemical Homeostasis Eosinophil Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Lymphocyte Migration Defense Response Positive Regulation Of Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Cell Migration Positive Regulation Of Behavior Regulation Of Cell Motility Granulocyte Chemotaxis Regulation Of Chemotaxis Homeostatic Process Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Behavior Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Monocyte Chemotaxis Negative Regulation Of Leukocyte Tethering Or Rolling Negative Regulation Of Leukocyte Migration Cellular Response To Stimulus Response To Stress Regulation Of Granulocyte Chemotaxis
Tagcloud ?		3kda attenuation blockage cd44 chemokines conclusively conversely cxcl1 cxcl2 cxcl6 dermal fibroblasts granulation ha healing hmw hyaluronan leukocytes lmw mediators mw nhdf players pro stromal supernatants tendency transferred wound
Tagcloud (Difference) ?		3kda attenuation blockage cd44 chemokines conclusively conversely cxcl1 cxcl2 cxcl6 dermal fibroblasts granulation ha healing hmw hyaluronan leukocytes lmw mediators mw nhdf players pro stromal supernatants tendency transferred wound
Tagcloud (Intersection) ?