CCL8 and CXCL8

Number of citations of the paper that reports this interaction (PubMedID 28381538)
0

Data Source:
BioGRID (pull down)

		CCL8	CXCL8
Description		C-C motif chemokine ligand 8	C-X-C motif chemokine ligand 8
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Protein Kinase Activity Cytokine Activity Protein Binding Chemokine Activity Heparin Binding Phospholipase Activator Activity CCR Chemokine Receptor Binding	Cytokine Activity Interleukin-8 Receptor Binding Protein Binding Chemokine Activity Heparin Binding CXCR Chemokine Receptor Binding
	Biological Process	Positive Regulation Of Leukocyte Migration Calcium Ion Transport Intracellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of Cell Migration Killing Of Cells Of Another Organism Host-mediated Suppression Of Viral Genome Replication Positive Regulation Of Myoblast Differentiation Eosinophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Negative Regulation Of Leukocyte Proliferation Positive Regulation Of Myoblast Fusion	Angiogenesis Response To Molecule Of Bacterial Origin Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-mediated Signaling Regulation Of Cell Adhesion Neutrophil Chemotaxis Receptor Internalization Killing Of Cells Of Another Organism Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Neutrophil Activation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiogenesis Embryonic Digestive Tract Development Induction Of Positive Chemotaxis Negative Regulation Of Cell Adhesion Molecule Production Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Neutrophil Chemotaxis Regulation Of Entry Of Bacterium Into Host Cell
Pathways			Senescence-Associated Secretory Phenotype (SASP) Peptide ligand-binding receptors Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress G alpha (i) signalling events Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling
Drugs		Pidolic acid	ABT-510 MDX-018 Rivanicline Oleandrin
Diseases
GWAS		Blood protein levels ( 30072576) Crohn's disease ( 22412388) Triglyceride levels in HIV infection ( 33109212)	Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566)
Interacting Genes		20 interacting genes: ACKR1 ACKR2 ACKR4 CCL11 CCL13 CCL2 CCL26 CCR1 CCR3 CCR5 CXCL10 CXCL11 CXCL17 CXCL2 CXCL6 CXCL8 MMP3 PPBP VCAN XCL2	23 interacting genes: ACKR1 ARFGAP3 BAG6 CCL2 CCL4 CCL5 CCL8 CTSL CXCR1 CXCR2 EP300 ERBB2 GNAI2 IL12A MMP14 MMP9 PF4 POMGNT1 SDC1 SGTA WASF1 ZFP36 ZNF598
Entrez ID		6355	3576
HPRD ID		03791	00909
Ensembl ID		ENSG00000108700	ENSG00000169429
Uniprot IDs		P80075	C9J4T6 P10145
PDB IDs		1ESR 7S59 7S5A	1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8 4XDX 5D14 5WDZ 6LFM 6LFO 6N2U 6WZM 6XMN 8IC0 8XWN 8XX6
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Chemokine-mediated Signaling Pathway Chemotaxis Locomotion Chemokine Activity Cell Migration Inflammatory Response Leukocyte Chemotaxis Cell Motility Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cytokine-mediated Signaling Pathway Leukocyte Migration Antimicrobial Humoral Response Immune Response Myeloid Leukocyte Migration G Protein-coupled Receptor Signaling Pathway Cytokine Activity Defense Response Humoral Immune Response Immune System Process Granulocyte Chemotaxis Granulocyte Migration C-C Chemokine Binding Defense Response To Symbiont Defense Response To Other Organism Mononuclear Cell Migration Chemokine Receptor Activity C-C Chemokine Receptor Activity Extracellular Space Killing Of Cells Of Another Organism CCR Chemokine Receptor Binding Response To External Biotic Stimulus Response To Stress Response To Other Organism Cellular Response To Lipopolysaccharide CXCR Chemokine Receptor Binding Cell Killing Cellular Response To Molecule Of Bacterial Origin Response To Molecule Of Bacterial Origin Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Extracellular Region Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Chemotaxis Calcium-mediated Signaling Response To Lipopolysaccharide Regulation Of Cell Migration	Chemokine-mediated Signaling Pathway Granulocyte Chemotaxis Granulocyte Migration Cell Surface Receptor Signaling Pathway Myeloid Leukocyte Migration Leukocyte Chemotaxis Cytokine-mediated Signaling Pathway Cell Migration Chemokine Activity Cell Chemotaxis Locomotion Eosinophil Chemotaxis Leukocyte Migration Eosinophil Migration C-C Chemokine Binding Cell Motility Positive Regulation Of Leukocyte Migration CCR Chemokine Receptor Binding Signal Transduction Chemotaxis Positive Regulation Of Mononuclear Cell Migration Inflammatory Response Mononuclear Cell Migration Cytokine Activity G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Leukocyte Migration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Response To Stress Immune System Process Regulation Of Mononuclear Cell Migration Dendritic Cell Chemotaxis Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Regulation Of Immune System Process Antimicrobial Humoral Response Receptor-mediated Endocytosis Host-mediated Perturbation Of Viral Process Positive Regulation Of Immune System Process Monocyte Chemotaxis Defense Response Dendritic Cell Migration Regulation Of Lymphocyte Chemotaxis Interleukin-8 Binding Positive Regulation Of Macrophage Migration Regulation Of Apoptotic Process Positive Regulation Of Leukocyte Chemotaxis Host-mediated Perturbation Of Viral Transcription
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