CCL8 and CCR1

Number of citations of the paper that reports this interaction (PMID 9115216)
14

Data Source:
HPRD (in vivo)

		CCL8	CCR1
Gene Name		chemokine (C-C motif) ligand 8	chemokine (C-C motif) receptor 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Protein Kinase Activity Chemokine Activity Heparin Binding Phospholipase Activator Activity	Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of Catalytic Activity Cell Chemotaxis	Dendritic Cell Chemotaxis Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Metabolic Process Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Calcium Ion Transport Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Crohn's disease ( 22412388)	Behcet's disease ( 23291587) Celiac disease ( 20190752 18311140)
Protein-Protein Interactions		8 interactors: ACKR1 ACKR2 ACKR4 CCR1 CCR3 CCR5 MMP3 VCAN	20 interactors: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CREB3 GNA14 JAK1 PLP2 STAT1 STAT3 TPST1 TPST2
Entrez ID		6355	1230
HPRD ID		03791	03101
Ensembl ID		ENSG00000108700	ENSG00000163823
Uniprot IDs		P80075	P32246 Q5U003
PDB IDs		1ESR	1Y5D
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Inflammatory Response Cellular Response To Organic Substance G-protein Coupled Receptor Signaling Pathway Chemotaxis Locomotion Response To Organic Substance Dendritic Cell Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Defense Response Dendritic Cell Migration Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway Response To External Stimulus Cellular Defense Response Response To Stress Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Immune Response Leukocyte Chemotaxis Cellular Chemical Homeostasis Ion Homeostasis Cellular Response To Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Homeostasis Negative Regulation Of Hydrogen Peroxide Metabolic Process Cell Chemotaxis Signal Transduction Cell Migration Chemical Homeostasis Leukocyte Migration Positive Regulation Of Oxidative Stress-induced Cell Death Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cell Motility Signaling Response To Stimulus Regulation Of Hydrogen Peroxide Metabolic Process Cell Communication Immune System Process Positive Regulation Of Monocyte Chemotaxis Sarcoplasmic Reticulum Calcium Ion Transport Dermatan Sulfate Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process	Cell Chemotaxis Chemotaxis Inflammatory Response Locomotion Cell Migration Cell Motility Immune Response Defense Response Response To External Stimulus Movement Of Cell Or Subcellular Component Monocyte Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Regulation Of Lymphocyte Migration Cellular Calcium Ion Homeostasis Immune System Process Calcium Ion Homeostasis Positive Regulation Of Leukocyte Migration Response To Stress Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Chemical Homeostasis Cellular Metal Ion Homeostasis Positive Regulation Of Behavior Regulation Of Chemotaxis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Chemotaxis Regulation Of Behavior Positive Regulation Of Cellular Component Movement Ion Homeostasis Positive Regulation Of Locomotion Cellular Response To Stimulus Positive Regulation Of Calcium Ion Transport Regulation Of Cell Migration Cell-cell Signaling Regulation Of Cell Motility Leukocyte Chemotaxis Response To Stimulus Lipopolysaccharide-mediated Signaling Pathway Eosinophil Chemotaxis Regulation Of Locomotion Homeostatic Process Regulation Of Cellular Component Movement Eosinophil Migration Cellular Homeostasis
Tagcloud ?		3kda attenuation blockage cd44 chemokines conclusively conversely cxcl1 cxcl2 cxcl6 dermal fibroblasts granulation ha healing hmw hyaluronan leukocytes lmw mediators mw nhdf players pro stromal supernatants tendency transferred wound	7b11 aminoxypentane augmented broadening ccr2 ccr3 ccr5 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Difference) ?		3kda attenuation blockage cd44 conclusively conversely cxcl1 cxcl2 cxcl6 dermal fibroblasts granulation ha healing hmw hyaluronan lmw mediators mw nhdf players pro stromal supernatants tendency transferred wound	7b11 aminoxypentane augmented broadening ccr2 ccr3 ccr5 chemokine chemotactic cxc cxcr1 eotaxin hcc2 mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Intersection) ?		chemokines leukocytes