CCL8 and ACKR1

Number of citations of the paper that reports this interaction (PMID 13679391)
13

Data Source:
HPRD (in vivo)

		CCL8	ACKR1
Gene Name		chemokine (C-C motif) ligand 8	atypical chemokine receptor 1 (Duffy blood group)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Early Endosome Plasma Membrane Integral Component Of Membrane Recycling Endosome
	Molecular Function	Protein Kinase Activity Chemokine Activity Heparin Binding Phospholipase Activator Activity	Receptor Activity Transmembrane Signaling Receptor Activity G-protein Coupled Receptor Activity C-C Chemokine Binding
	Biological Process	Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of Catalytic Activity Cell Chemotaxis	Defense Response Inflammatory Response G-protein Coupled Receptor Signaling Pathway Regulation Of Chemokine Production Chemokine-mediated Signaling Pathway
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Crohn's disease ( 22412388)
Protein-Protein Interactions		8 interactors: ACKR1 ACKR2 ACKR4 CCR1 CCR3 CCR5 MMP3 VCAN	8 interactors: CCL17 CCL2 CCL5 CCL7 CCL8 CXCL1 CXCL5 CXCL8
Entrez ID		6355	2532
HPRD ID		03791	00192
Ensembl ID		ENSG00000108700	ENSG00000213088
Uniprot IDs		P80075	Q16570 Q5Y7A1 Q5Y7A2
PDB IDs		1ESR
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Inflammatory Response Cellular Response To Organic Substance G-protein Coupled Receptor Signaling Pathway Chemotaxis Locomotion Response To Organic Substance Dendritic Cell Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Defense Response Dendritic Cell Migration Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway Response To External Stimulus Cellular Defense Response Response To Stress Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Immune Response Leukocyte Chemotaxis Cellular Chemical Homeostasis Ion Homeostasis Cellular Response To Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Homeostasis Negative Regulation Of Hydrogen Peroxide Metabolic Process Cell Chemotaxis Signal Transduction Cell Migration Chemical Homeostasis Leukocyte Migration Positive Regulation Of Oxidative Stress-induced Cell Death Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cell Motility Signaling Response To Stimulus Regulation Of Hydrogen Peroxide Metabolic Process Cell Communication Immune System Process Positive Regulation Of Monocyte Chemotaxis Sarcoplasmic Reticulum Calcium Ion Transport Dermatan Sulfate Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process	Cell Chemotaxis Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Regulation Of Chemotaxis Cell Migration Chemokine-mediated Signaling Pathway Cell Motility Regulation Of Behavior Locomotion Immune Response Defense Response Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Movement Of Cell Or Subcellular Component Positive Regulation Of Locomotion Response To External Stimulus Granulocyte Chemotaxis Immune System Process Regulation Of Cell Migration Regulation Of Cell Motility Monocyte Chemotaxis Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Other Organism Response To Lipopolysaccharide Leukocyte Chemotaxis Response To Biotic Stimulus Response To Molecule Of Bacterial Origin Positive Regulation Of Immune System Process Regulation Of Lymphocyte Migration Cytokine-mediated Signaling Pathway Response To Bacterium Regulation Of Granulocyte Chemotaxis Response To Stress G-protein Coupled Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Leukocyte Migration Regulation Of Immune System Process Cellular Response To Interleukin-1 Positive Regulation Of Natural Killer Cell Chemotaxis Response To Cytokine Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Macrophage Chemotaxis
Tagcloud ?		3kda attenuation blockage cd44 chemokines conclusively conversely cxcl1 cxcl2 cxcl6 dermal fibroblasts granulation ha healing hmw hyaluronan leukocytes lmw mediators mw nhdf players pro stromal supernatants tendency transferred wound
Tagcloud (Difference) ?		3kda attenuation blockage cd44 chemokines conclusively conversely cxcl1 cxcl2 cxcl6 dermal fibroblasts granulation ha healing hmw hyaluronan leukocytes lmw mediators mw nhdf players pro stromal supernatants tendency transferred wound
Tagcloud (Intersection) ?