CCL8 and CCR3

Number of citations of the paper that reports this interaction (PMID 9005985)
61

Data Source:
HPRD (in vitro, in vivo)

		CCL8	CCR3
Gene Name		chemokine (C-C motif) ligand 8	chemokine (C-C motif) receptor 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Kinase Activity Chemokine Activity Heparin Binding Phospholipase Activator Activity	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity
	Biological Process	Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of Catalytic Activity Cell Chemotaxis	Positive Regulation Of Endothelial Cell Proliferation Chemotaxis Inflammatory Response Cellular Defense Response Cell Adhesion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Viral Process Positive Regulation Of Angiogenesis Chemokine-mediated Signaling Pathway
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Crohn's disease ( 22412388)	Behcet's disease ( 23291587) Celiac disease ( 20190752 18311140) Monocyte chemoattractant protein-1 ( 23017229) Obesity-related traits ( 23251661)
Protein-Protein Interactions		8 interactors: ACKR1 ACKR2 ACKR4 CCR1 CCR3 CCR5 MMP3 VCAN	19 interactors: CCL11 CCL13 CCL14 CCL15 CCL2 CCL24 CCL26 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CXCL10 CXCL11 CXCL9 FGR HCK
Entrez ID		6355	1232
HPRD ID		03791	03167
Ensembl ID		ENSG00000108700	ENSG00000183625
Uniprot IDs		P80075	P51677 Q8TDP4 Q8TDP5
PDB IDs		1ESR
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Inflammatory Response Cellular Response To Organic Substance G-protein Coupled Receptor Signaling Pathway Chemotaxis Locomotion Response To Organic Substance Dendritic Cell Chemotaxis Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Defense Response Dendritic Cell Migration Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway Response To External Stimulus Cellular Defense Response Response To Stress Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Immune Response Leukocyte Chemotaxis Cellular Chemical Homeostasis Ion Homeostasis Cellular Response To Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Homeostasis Negative Regulation Of Hydrogen Peroxide Metabolic Process Cell Chemotaxis Signal Transduction Cell Migration Chemical Homeostasis Leukocyte Migration Positive Regulation Of Oxidative Stress-induced Cell Death Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cell Motility Signaling Response To Stimulus Regulation Of Hydrogen Peroxide Metabolic Process Cell Communication Immune System Process Positive Regulation Of Monocyte Chemotaxis Sarcoplasmic Reticulum Calcium Ion Transport Dermatan Sulfate Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process	Cell Chemotaxis Cell Migration Cell Motility Chemotaxis Locomotion Immune Response Movement Of Cell Or Subcellular Component Inflammatory Response Response To External Stimulus Immune System Process Leukocyte Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Leukocyte Migration Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Eosinophil Chemotaxis Positive Regulation Of Leukocyte Migration Defense Response Eosinophil Migration Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Leukocyte Chemotaxis Regulation Of Cellular Component Movement Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Chemotaxis Granulocyte Chemotaxis Positive Regulation Of Behavior Regulation Of Chemotaxis Regulation Of Lymphocyte Migration Cellular Metal Ion Homeostasis Regulation Of Cell Shape Cellular Cation Homeostasis Cell-cell Signaling Cellular Ion Homeostasis Positive Regulation Of Calcium Ion Transport Metal Ion Homeostasis Regulation Of Behavior Response To Other Organism Lymphocyte Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Response To Biotic Stimulus T Cell Migration Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Immune System Process Regulation Of Immune System Process
Tagcloud ?		3kda attenuation blockage cd44 chemokines conclusively conversely cxcl1 cxcl2 cxcl6 dermal fibroblasts granulation ha healing hmw hyaluronan leukocytes lmw mediators mw nhdf players pro stromal supernatants tendency transferred wound	basophil basophils c5a ccr2 chains chemoattractant chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly
Tagcloud (Difference) ?		3kda attenuation blockage cd44 chemokines conclusively conversely cxcl1 cxcl2 cxcl6 dermal fibroblasts granulation ha healing hmw hyaluronan leukocytes lmw mediators mw nhdf players pro stromal supernatants tendency transferred wound	basophil basophils c5a ccr2 chains chemoattractant chemotactic continuous continuously cxcr1 cxcr2 eotaxin express fmlp formyl granulocyte hardly leu leukotrienes lt ltc4 macrophage mcp mcp1 mediate migratory phe unrelated weakly
Tagcloud (Intersection) ?