CCL8 and CCR3

Number of citations: 49 (PubMedID 9005985)
Data Source: HPRD (in vitro, in vivo)

		CCL8	CCR3
Name		C-C motif chemokine ligand 8	C-C motif chemokine receptor 3
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Protein Kinase Activity Cytokine Activity Protein Binding Chemokine Activity Heparin Binding Phospholipase Activator Activity CCR Chemokine Receptor Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Positive Regulation Of Leukocyte Migration Calcium Ion Transport Intracellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of Cell Migration Killing Of Cells Of Another Organism Host-mediated Suppression Of Viral Genome Replication Positive Regulation Of Myoblast Differentiation Eosinophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Negative Regulation Of Leukocyte Proliferation Positive Regulation Of Myoblast Fusion	Positive Regulation Of Endothelial Cell Proliferation Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Positive Regulation Of Angiogenesis Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus
Pathways		None	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Pidolic acid	None
GWAS		Blood protein levels ( 30072576 ) Crohn's disease ( 22412388 ) Triglyceride levels in HIV infection ( 33109212 )	Arthritis (juvenile idiopathic) ( 33106285 ) Basophil count ( 32888494 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 32888494 27863252 ) Behcet's disease ( 33393726 23291587 ) Bone mineral density (Ward's triangle area) ( 27397699 ) Celiac disease ( 25920553 20190752 22057235 24999842 18311140 ) Celiac disease and Rheumatoid arthritis ( 26546613 ) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Inflammatory bowel disease ( 26192919 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Monocyte chemoattractant protein-1 levels ( 23017229 ) Monocyte count ( 27863252 29403010 ) Narcolepsy with cataplexy ( 25986216 ) Obesity-related traits ( 23251661 ) Pancreatic beta-cell glucose sensitivity ( 32944759 ) Ulcerative colitis ( 26192919 28067908 ) White blood cell count (basophil) ( 27863252 )
Novel Interactors		1 novel interactors: SDF2	None recorded
Interacting Genes		20 interacting genes: ACKR1 ACKR2 ACKR4 CCL11 CCL13 CCL2 CCL26 CCR1 CCR3 CCR5 CXCL10 CXCL11 CXCL17 CXCL2 CXCL6 CXCL8 MMP3 PPBP VCAN XCL2	19 interacting genes: CCL11 CCL13 CCL14 CCL15 CCL2 CCL24 CCL26 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CXCL10 CXCL11 CXCL9 FGR HCK
Entrez ID		6355	1232
HPRD ID		03791	03167
Ensembl ID		ENSG00000108700	ENSG00000183625
Uniprot IDs		P80075	P51677 Q8TDP4 Q8TDP5
PDB IDs		1ESR 7S59 7S5A	7X9Y
GO Terms Enriched among Interactors		Cell Chemotaxis Chemokine-mediated Signaling Pathway Chemotaxis Locomotion Chemokine Activity Cell Migration Inflammatory Response Leukocyte Chemotaxis Cell Motility Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cytokine-mediated Signaling Pathway Leukocyte Migration Antimicrobial Humoral Response Immune Response Myeloid Leukocyte Migration G Protein-coupled Receptor Signaling Pathway Cytokine Activity Defense Response Humoral Immune Response Immune System Process Granulocyte Chemotaxis Granulocyte Migration C-C Chemokine Binding Defense Response To Symbiont Defense Response To Other Organism Mononuclear Cell Migration Chemokine Receptor Activity C-C Chemokine Receptor Activity Extracellular Space Killing Of Cells Of Another Organism CCR Chemokine Receptor Binding Response To External Biotic Stimulus Response To Stress Response To Other Organism Cellular Response To Lipopolysaccharide CXCR Chemokine Receptor Binding Cell Killing Cellular Response To Molecule Of Bacterial Origin Response To Molecule Of Bacterial Origin Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Extracellular Region Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Chemotaxis Calcium-mediated Signaling Response To Lipopolysaccharide Regulation Of Cell Migration	Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway CCR Chemokine Receptor Binding Antimicrobial Humoral Response Cell Chemotaxis Cytokine Activity Humoral Immune Response Chemotaxis Granulocyte Chemotaxis Locomotion Defense Response To Symbiont Inflammatory Response Defense Response To Other Organism Granulocyte Migration Eosinophil Chemotaxis Cytokine-mediated Signaling Pathway Leukocyte Chemotaxis Eosinophil Migration Leukocyte Migration Myeloid Leukocyte Migration Response To Other Organism Immune Response Cell Migration Response To External Biotic Stimulus Defense Response Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Locomotion Immune System Process Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Extracellular Space Cell Surface Receptor Signaling Pathway Extracellular Region Response To Stress Regulation Of Lymphocyte Chemotaxis Cell-cell Signaling Signaling Cell Communication Regulation Of Leukocyte Migration Regulation Of Cell Shape Positive Regulation Of Leukocyte Migration Signal Transduction Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Calcium Ion Transport Intracellular Calcium Ion Homeostasis