MAPK12 and DLG2

Number of citations of the paper that reports this interaction (PMID 16637659)
18

Data Source:
HPRD (in vitro)

		MAPK12	DLG2
Gene Name		mitogen-activated protein kinase 12	discs, large homolog 2 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol	Plasma Membrane Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Cell Junction Juxtaparanode Region Of Axon Postsynaptic Membrane
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding	Guanylate Kinase Activity Protein Binding Ionotropic Glutamate Receptor Binding
	Biological Process	MAPK Cascade Transcription, DNA-templated Regulation Of Transcription, DNA-templated DNA Damage Induced Protein Phosphorylation Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Ras Protein Signal Transduction Muscle Organ Development Positive Regulation Of Peptidase Activity Peptidyl-serine Phosphorylation Muscle Cell Differentiation Myoblast Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Muscle Cell Differentiation	Synaptic Transmission Nervous System Development Negative Regulation Of Phosphatase Activity Sensory Perception Of Pain Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Receptor Localization To Synapse
Pathways		Signalling to ERKs Signalling by NGF Organelle biogenesis and maintenance CDO in myogenesis NGF signalling via TRKA from the plasma membrane VEGFA-VEGFR2 Pathway Mitochondrial biogenesis DSCAM interactions Activation of PPARGC1A (PGC-1alpha) by phosphorylation Myogenesis Signaling by VEGF NOD1/2 Signaling Pathway Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways p38MAPK events Signalling to RAS Innate Immune System
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Parkinson's disease ( 17052657) Phospholipid levels (plasma) ( 22359512) Protein quantitative trait loci ( 18464913) Wilms tumor ( 22544364)
Protein-Protein Interactions		25 interactors: DLG1 DLG2 DLG3 DLG4 DUSP1 EEF2K ERBB2IP GRB2 GTF2I HTRA2 INADL MAP2K3 MAP2K4 MAP2K6 MAPKAPK5 MAPT MBP PKN1 RGS3 SH3BP5 SIAH1 SNTA1 SNTB1 SRPK1 TERF1	40 interactors: ABCA1 ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 ERBB4 FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 SCN4A SCN5A SEMA4C WNT3A
Entrez ID		6300	1740
HPRD ID		03868	04663
Ensembl ID		ENSG00000188130	ENSG00000150672
Uniprot IDs		B7Z274 P53778	B7Z2T4 E9PN83 Q15700
PDB IDs		1CM8	2BYG 2HE2
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Regulation Of Phosphorus Metabolic Process Protein Localization To Synapse Regulation Of Catalytic Activity Regulation Of MAP Kinase Activity Regulation Of Cellular Protein Metabolic Process Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Signaling Regulation Of Intracellular Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Cell Communication Regulation Of Metabolic Process Regulation Of MAPK Cascade Muscle System Process Receptor Clustering Activation Of Protein Kinase Activity Activation Of MAPK Activity Nucleotide Phosphorylation Response To Stimulus Regulation Of Cellular Process Phosphorylation Intracellular Signal Transduction Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of MAP Kinase Activity Muscle Contraction Cellular Response To Sorbitol MAPK Cascade Positive Regulation Of Protein Polymerization Positive Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Phosphate-containing Compound Metabolic Process Positive Regulation Of Catalytic Activity Axonogenesis Positive Regulation Of Transferase Activity Regulation Of Signaling Axon Development Cell Morphogenesis Involved In Neuron Differentiation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Apoptotic Process	Cell-cell Signaling Synaptic Transmission Membrane Depolarization Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Membrane Potential Regulation Of Ion Transport Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Neuron-neuron Synaptic Transmission Neuromuscular Process Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Ion Transmembrane Transport Neurological System Process Regulation Of Signaling Glutamate Receptor Signaling Pathway Startle Response Ion Transport Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Signal Transduction Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Sodium Ion Transmembrane Transport Nervous System Development Metal Ion Transport Transmembrane Transport Positive Regulation Of Membrane Potential Transport Negative Regulation Of Adrenergic Receptor Signaling Pathway Neuron Differentiation Cation Transmembrane Transport Protein Localization To Synapse Positive Regulation Of Transport Neurogenesis Behavior Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Regulation Of Receptor Activity Metencephalon Development Regulation Of Respiratory Gaseous Exchange Regulation Of Cellular Process Regulation Of Sodium Ion Transport Generation Of Neurons Postsynaptic Membrane Organization Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cell Morphogenesis Involved In Differentiation Postsynaptic Membrane Assembly
Tagcloud ?		6j acpp canonical carcinogenic cdk5 delineate e2f6 elf1 glands gprc5a hindered ingenuity ionizing ipa map2 mapped microarray nab2 persistently perturbed plcg1 ppp4c radiation runx1 scarcity sema4d stathmin1 surgically undertook	17q12 apical basolateral defining disc discs dlg3 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Difference) ?		6j acpp canonical carcinogenic cdk5 delineate e2f6 elf1 glands gprc5a hindered ingenuity ionizing ipa map2 mapped microarray nab2 persistently perturbed plcg1 ppp4c radiation runx1 scarcity sema4d stathmin1 surgically undertook	17q12 apical basolateral defining disc discs dlg3 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Intersection) ?