MAPK12 and RCSD1

Number of citations of the paper that reports this interaction (PubMedID 15850461)
32

Data Source:
BioGRID (enzymatic study)

		MAPK12	RCSD1
Description		mitogen-activated protein kinase 12	RCSD domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Early Endosome Cytosol Actin Filament WASH Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Peptidase Activator Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Actin Filament Binding Phosphatidylinositol Phosphate Binding Retromer Complex Binding
	Biological Process	MAPK Cascade Signal Transduction Muscle Organ Development Cellular Response To Stress Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Myoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Muscle Cell Differentiation Regulation Of Cell Cycle	Skeletal Muscle Contraction Protein Localization To Endosome Retrograde Transport, Endosome To Golgi Cellular Hyperosmotic Response
Pathways		NOD1/2 Signaling Pathway p38MAPK events Activation of PPARGC1A (PGC-1alpha) by phosphorylation VEGFA-VEGFR2 Pathway Myogenesis Myogenesis Negative regulation of MAPK pathway
Drugs		Minocycline Phosphonothreonine Phosphoaminophosphonic Acid-Adenylate Ester KC706 CEP-1347
Diseases
GWAS		Acne (severe) ( 24927181) Diverticular disease ( 30177863) Triiodothyronine levels and thyroxine levels ( 30843173)	Asthma ( 31959851) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		30 interacting genes: CDK1 DLG1 DLG2 DLG3 DLG4 DUSP1 EEF2K ERBIN GRB2 GTF2I HTRA2 MAP2K3 MAP2K4 MAP2K6 MAPKAPK5 MAPT MBP PATJ PDGFRL PKN1 PTPN3 PTPN4 RCSD1 RGS3 SH3BP5 SIAH1 SNTA1 SNTB1 SRPK1 TERF1	3 interacting genes: MAPK12 MAPKAPK2 MAPKAPK3
Entrez ID		6300	92241
HPRD ID		03868	10077
Ensembl ID		ENSG00000188130	ENSG00000198771
Uniprot IDs		P53778	B7ZKW8 Q6JBY9
PDB IDs		1CM8 4QUM 6UNA 7CGA
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity MAPK Cascade Neuromuscular Junction Intracellular Signal Transduction MAP Kinase Kinase Activity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Ionotropic Glutamate Receptor Binding Protein Serine/threonine Kinase Activity Establishment Or Maintenance Of Cell Polarity Protein Kinase Binding Intracellular Signaling Cassette Muscle Contraction Signal Transduction Protein Kinase Activity Receptor Localization To Synapse Receptor Clustering Protein Serine Kinase Activity Cytoplasm Cytosol Protein Localization To Synapse Muscle System Process Cellular Senescence Kinase Activity Protein Localization To Cell Junction Response To Metal Ion Calmodulin Binding Negative Regulation Of Cell Cycle Kinase Binding Postsynaptic Density Membrane Cytoplasmic Side Of Plasma Membrane Regulation Of Sodium Ion Transmembrane Transport Regulation Of Chromosome Organization NLRP1 Inflammasome Complex Assembly Phosphoprotein Phosphatase Activity Negative Regulation Of P38MAPK Cascade GMP Kinase Activity Cellular Response To Brain-derived Neurotrophic Factor Stimulus Cellular Response To Growth Factor Stimulus System Process GDP Metabolic Process Regulation Of Multicellular Organismal Process Chemical Synaptic Transmission Juxtaparanode Region Of Axon Response To Growth Factor Positive Regulation Of Organelle Organization Regulation Of Signal Transduction Regulation Of Sodium Ion Transport Cytoskeletal Protein Binding Cellular Response To Potassium Ion	Macropinocytosis Calcium-dependent Protein Serine/threonine Kinase Activity Pinocytosis MAPK Cascade Calcium/calmodulin-dependent Protein Kinase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Kinase Activity Toll-like Receptor Signaling Pathway Kinase Activity Intracellular Signaling Cassette Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Calmodulin Binding Activation Of Innate Immune Response ATP Binding Nucleotide Binding Transferase Activity Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Immune Response-activating Signaling Pathway Peptidase Activator Activity Immune Response-regulating Signaling Pathway Activation Of Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Endocytosis Regulation Of Innate Immune Response Positive Regulation Of Defense Response MAP Kinase Kinase Activity Regulation Of Cellular Response To Heat MAP Kinase Activity Response To Cytokine Response To Peptide 3'-UTR-mediated MRNA Stabilization Import Into Cell Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of Immune Response P38MAPK Cascade Cellular Response To Vascular Endothelial Growth Factor Stimulus Leukotriene Metabolic Process Myoblast Differentiation DNA Damage Response Response To Lipid Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Regulation Of Defense Response
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