MAPK12 and SH3BP5

Number of citations of the paper that reports this interaction (PubMedID 15158451)
0

Data Source:
HPRD (in vitro)

		MAPK12	SH3BP5
Description		mitogen-activated protein kinase 12	SH3 domain binding protein 5
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Nucleoplasm Cytoplasm Mitochondrion Membrane Nuclear Body Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Peptidase Activator Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Protein Kinase Inhibitor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding
	Biological Process	MAPK Cascade Signal Transduction Muscle Organ Development Cellular Response To Stress Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Myoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Muscle Cell Differentiation Regulation Of Cell Cycle	Signal Transduction Intracellular Signal Transduction
Pathways		NOD1/2 Signaling Pathway p38MAPK events Activation of PPARGC1A (PGC-1alpha) by phosphorylation VEGFA-VEGFR2 Pathway Myogenesis Myogenesis Negative regulation of MAPK pathway
Drugs		Minocycline Phosphonothreonine Phosphoaminophosphonic Acid-Adenylate Ester KC706 CEP-1347
Diseases
GWAS		Acne (severe) ( 24927181) Diverticular disease ( 30177863) Triiodothyronine levels and thyroxine levels ( 30843173)	Alcohol and nicotine co-dependence ( 22488850) Alcohol dependence ( 21956439) Heschl's gyrus morphology ( 25130324) Prudent dietary pattern ( 28644415)
Interacting Genes		30 interacting genes: CDK1 DLG1 DLG2 DLG3 DLG4 DUSP1 EEF2K ERBIN GRB2 GTF2I HTRA2 MAP2K3 MAP2K4 MAP2K6 MAPKAPK5 MAPT MBP PATJ PDGFRL PKN1 PTPN3 PTPN4 RCSD1 RGS3 SH3BP5 SIAH1 SNTA1 SNTB1 SRPK1 TERF1	16 interacting genes: APP BTK CDC5L DISC1 DST EXOC1 IFT20 MAPK10 MAPK12 MAPK8 MAPK9 NAP1L2 SOS1 SPTBN1 SYNE1 TTC3
Entrez ID		6300	9467
HPRD ID		03868	12030
Ensembl ID		ENSG00000188130	ENSG00000131370
Uniprot IDs		P53778	O60239
PDB IDs		1CM8 4QUM 6UNA 7CGA	4H3B 6DJL 6IXE 6IXF 6IXG 6IXV
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity MAPK Cascade Neuromuscular Junction Intracellular Signal Transduction MAP Kinase Kinase Activity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Ionotropic Glutamate Receptor Binding Protein Serine/threonine Kinase Activity Establishment Or Maintenance Of Cell Polarity Protein Kinase Binding Intracellular Signaling Cassette Muscle Contraction Signal Transduction Protein Kinase Activity Receptor Localization To Synapse Receptor Clustering Protein Serine Kinase Activity Cytoplasm Cytosol Protein Localization To Synapse Muscle System Process Cellular Senescence Kinase Activity Protein Localization To Cell Junction Response To Metal Ion Calmodulin Binding Negative Regulation Of Cell Cycle Kinase Binding Postsynaptic Density Membrane Cytoplasmic Side Of Plasma Membrane Regulation Of Sodium Ion Transmembrane Transport Regulation Of Chromosome Organization NLRP1 Inflammasome Complex Assembly Phosphoprotein Phosphatase Activity Negative Regulation Of P38MAPK Cascade GMP Kinase Activity Cellular Response To Brain-derived Neurotrophic Factor Stimulus Cellular Response To Growth Factor Stimulus System Process GDP Metabolic Process Regulation Of Multicellular Organismal Process Chemical Synaptic Transmission Juxtaparanode Region Of Axon Response To Growth Factor Positive Regulation Of Organelle Organization Regulation Of Signal Transduction Regulation Of Sodium Ion Transport Cytoskeletal Protein Binding Cellular Response To Potassium Ion	Fc-epsilon Receptor Signaling Pathway JUN Kinase Activity MAP Kinase Activity Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette Intracellular Signal Transduction Cytoplasm Cell Surface Receptor Signaling Pathway Peptidase Activator Activity Immune Response-regulating Signaling Pathway JNK Cascade Cellular Senescence MAPK Cascade Protein Kinase Activity Positive Regulation Of Cell Differentiation Regulation Of Immune Response Cellular Response To Reactive Oxygen Species Regulation Of Circadian Rhythm Response To Light Stimulus Kinase Activity Protein Serine/threonine Kinase Binding Regulation Of Cell Differentiation Signal Transduction Protein Phosphorylation Protein Serine Kinase Activity Positive Regulation Of Cellular Component Organization Phosphorylation Axon Cytosol Response To Reactive Oxygen Species Positive Regulation Of NLRP3 Inflammasome Complex Assembly Protein Serine/threonine Kinase Activity Transport Along Microtubule Regulation Of Protein-containing Complex Assembly Response To Radiation Positive Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium Cytoskeleton-dependent Intracellular Transport Regulation Of Response To Calcium Ion Response To Stress Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Developmental Process Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Cellular Response To Oxidative Stress Positive Regulation Of Protein-containing Complex Assembly
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