MAPK12 and RGS3

Number of citations of the paper that reports this interaction (PubMedID 16637659)
54

Data Source:
HPRD (in vitro)

		MAPK12	RGS3
Description		mitogen-activated protein kinase 12	regulator of G protein signaling 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Peptidase Activator Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	GTPase Activity GTPase Activator Activity Protein Binding
	Biological Process	MAPK Cascade Signal Transduction Muscle Organ Development Cellular Response To Stress Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Myoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Muscle Cell Differentiation Regulation Of Cell Cycle	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction
Pathways		NOD1/2 Signaling Pathway p38MAPK events Activation of PPARGC1A (PGC-1alpha) by phosphorylation VEGFA-VEGFR2 Pathway Myogenesis Myogenesis Negative regulation of MAPK pathway	G alpha (q) signalling events G alpha (i) signalling events
Drugs		Minocycline Phosphonothreonine Phosphoaminophosphonic Acid-Adenylate Ester KC706 CEP-1347
Diseases
GWAS		Acne (severe) ( 24927181) Diverticular disease ( 30177863) Triiodothyronine levels and thyroxine levels ( 30843173)	Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Red blood cell count ( 32888494) Refractive error ( 32231278)
Interacting Genes		30 interacting genes: CDK1 DLG1 DLG2 DLG3 DLG4 DUSP1 EEF2K ERBIN GRB2 GTF2I HTRA2 MAP2K3 MAP2K4 MAP2K6 MAPKAPK5 MAPT MBP PATJ PDGFRL PKN1 PTPN3 PTPN4 RCSD1 RGS3 SH3BP5 SIAH1 SNTA1 SNTB1 SRPK1 TERF1	24 interacting genes: ACD APP CNKSR2 CYSRT1 DEPDC1B EFNB1 EFNB2 ESR1 GLS2 GNA11 GNAI3 GORASP2 GRIN2A HES4 HIPK3 MAPK12 PAX6 PLSCR1 PRKN SCN5A YWHAB YWHAE YWHAQ YWHAZ
Entrez ID		6300	5998
HPRD ID		03868	03720
Ensembl ID		ENSG00000188130	ENSG00000138835
Uniprot IDs		P53778	A0A087WUY2 A0A8Q3WKG2 B3KVT7 B3KWG8 H7BXY1 P49796 Q53GP3
PDB IDs		1CM8 4QUM 6UNA 7CGA	2F5Y 2OJ4 3FBK
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity MAPK Cascade Neuromuscular Junction Intracellular Signal Transduction MAP Kinase Kinase Activity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Ionotropic Glutamate Receptor Binding Protein Serine/threonine Kinase Activity Establishment Or Maintenance Of Cell Polarity Protein Kinase Binding Intracellular Signaling Cassette Muscle Contraction Signal Transduction Protein Kinase Activity Receptor Localization To Synapse Receptor Clustering Protein Serine Kinase Activity Cytoplasm Cytosol Protein Localization To Synapse Muscle System Process Cellular Senescence Kinase Activity Protein Localization To Cell Junction Response To Metal Ion Calmodulin Binding Negative Regulation Of Cell Cycle Kinase Binding Postsynaptic Density Membrane Cytoplasmic Side Of Plasma Membrane Regulation Of Sodium Ion Transmembrane Transport Regulation Of Chromosome Organization NLRP1 Inflammasome Complex Assembly Phosphoprotein Phosphatase Activity Negative Regulation Of P38MAPK Cascade GMP Kinase Activity Cellular Response To Brain-derived Neurotrophic Factor Stimulus Cellular Response To Growth Factor Stimulus System Process GDP Metabolic Process Regulation Of Multicellular Organismal Process Chemical Synaptic Transmission Juxtaparanode Region Of Axon Response To Growth Factor Positive Regulation Of Organelle Organization Regulation Of Signal Transduction Regulation Of Sodium Ion Transport Cytoskeletal Protein Binding Cellular Response To Potassium Ion	Phosphoserine Residue Binding Enzyme Binding G Protein-coupled Receptor Binding Ephrin Receptor Binding Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Developmental Process Protein Domain Specific Binding Regulation Of Spontaneous Synaptic Transmission Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Membrane Potential Ligand-gated Ion Channel Signaling Pathway Protein Sequestering Activity Signal Transduction Regulation Of Transport Protein Kinase Binding Negative Regulation Of Protein Localization To Nucleus Transmembrane Transporter Binding Modulation Of Excitatory Postsynaptic Potential Regulation Of Monoatomic Ion Transmembrane Transport Peptidase Activator Activity System Development Cellular Response To Manganese Ion Extracellular Exosome Ubiquitin Protein Ligase Binding Regulation Of Establishment Of Protein Localization Glutamatergic Synapse Regulation Of MiRNA Transcription Response To Manganese Ion Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Targeting Regulation Of Protein Localization Negative Regulation Of Protein Localization Response To Lead Ion Negative Regulation Of RNA Biosynthetic Process Regulation Of Monoatomic Ion Transport Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Cellular Response To Catecholamine Stimulus Regulation Of Protein Transport Regulation Of Neurotransmitter Uptake Response To Catecholamine Focal Adhesion Guanyl Nucleotide Binding Startle Response Negative Regulation Of Transport Regulation Of Innate Immune Response Positive Regulation Of Protein Transport Melanosome Negative Regulation Of Macromolecule Metabolic Process G-protein Beta/gamma-subunit Complex Binding
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