SAA2 and COL4A1

Number of citations of the paper that reports this interaction (PMID 8995276)
1

Data Source:
HPRD (in vitro)

		SAA2	COL4A1
Gene Name		serum amyloid A2	collagen, type IV, alpha 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	High-density Lipoprotein Particle Extracellular Vesicular Exosome	Extracellular Region Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function		Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Constituent Conferring Elasticity Platelet-derived Growth Factor Binding
	Biological Process	Acute-phase Response	Patterning Of Blood Vessels Receptor-mediated Endocytosis Axon Guidance Brain Development Neuromuscular Junction Development Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Epithelial Cell Differentiation Blood Vessel Morphogenesis Retinal Blood Vessel Morphogenesis Renal Tubule Morphogenesis Cellular Response To Amino Acid Stimulus Basement Membrane Organization
Pathways			Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Laminin interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth Scavenging by Class A Receptors
Drugs
Diseases
GWAS			Arterial stiffness ( 20031579) Coronary heart disease ( 21378990) Obesity-related traits ( 23251661)
Protein-Protein Interactions		3 interactors: APOA1 COL4A1 LAMA1	27 interactors: ACHE APCS APP BMP3 CD93 COL4A2 COL7A1 DCN DISC1 FBLN2 FN1 HABP2 MAG MATN2 MMP9 NID1 NID2 OSM PDGFA PDGFB SAA1 SAA2 SAA4 SERPINE2 SMAD1 TGFBI THBS1
Entrez ID		6289	1282
HPRD ID		00098	00359
Ensembl ID		ENSG00000134339	ENSG00000187498
Uniprot IDs		P0DJI9	P02462
PDB IDs			1LI1
Enriched GO Terms of Interacting Partners?		Retinal Blood Vessel Morphogenesis Retina Vasculature Morphogenesis In Camera-type Eye Retina Vasculature Development In Camera-type Eye Axon Development Chemotaxis Neuron Projection Development Neuron Development Regulation Of Embryonic Development Neuron Differentiation Cell Projection Organization Negative Regulation Of Cell Adhesion Molecule Production Retina Development In Camera-type Eye Locomotion Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Interleukin-1 Beta Secretion Movement Of Cell Or Subcellular Component Generation Of Neurons Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import Neurogenesis Negative Regulation Of Interleukin-1 Secretion Cell Development Response To External Stimulus Establishment Of Epithelial Cell Apical/basal Polarity Receptor-mediated Endocytosis High-density Lipoprotein Particle Clearance Camera-type Eye Development Extracellular Matrix Organization Extracellular Structure Organization Epithelial Tube Morphogenesis Protein Oxidation Axon Guidance Eye Development Negative Regulation Of Heterotypic Cell-cell Adhesion Establishment Of Apical/basal Cell Polarity Negative Regulation Of Cytokine Secretion Involved In Immune Response High-density Lipoprotein Particle Assembly Polarized Epithelial Cell Differentiation Nervous System Development Blood Vessel Morphogenesis Tube Morphogenesis Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Cholesterol Esterification Regulation Of Intestinal Cholesterol Absorption Phospholipid Homeostasis Peptidyl-methionine Modification Establishment Of Monopolar Cell Polarity Gland Development	Extracellular Matrix Organization Extracellular Structure Organization Response To Wounding Wound Healing Acute-phase Response Extracellular Matrix Disassembly Tissue Development Blood Coagulation Platelet Degranulation Hemostasis Acute Inflammatory Response Multicellular Organismal Development System Development Cell Adhesion Anatomical Structure Development Locomotion Platelet Activation Response To Stress Endodermal Cell Differentiation Regulation Of Body Fluid Levels Developmental Process Formation Of Primary Germ Layer Regulation Of Wound Healing Inflammatory Response Endoderm Formation Anatomical Structure Morphogenesis Negative Regulation Of Platelet Activation Negative Regulation Of Wound Healing Organ Development Defense Response Negative Regulation Of Phosphatidylinositol Biosynthetic Process Gastrulation Cell Migration Movement Of Cell Or Subcellular Component Endoderm Development Chemotaxis Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Cell Differentiation Regulation Of Blood Coagulation Regulation Of Platelet Activation Cell Motility Response To Stimulus Leukocyte Migration Connective Tissue Development Blood Vessel Morphogenesis Negative Regulation Of Phospholipid Biosynthetic Process Cell Activation Immune System Process Regulation Of Protein Metabolic Process
Tagcloud ?		10scn 1rn alleles amyloidosis c57bl chemotaxis del deposit differently efficacious encoded equally familiar fever formyl fpr2 isoforms mediterranean mobilization modulating predominant preference robust saa1 selectivity tlr2 tlr4lps toll	arteriopathy autosomal cadasil cavitary confirms eif2b encountered entity excluded fifty frequencies heterogeneous increasingly infancy infarcts inherited leukoencephalopathies leukoencephalopathy magnetic matter onset oriented realized resonance subcortical symmetrical systematic underestimated white
Tagcloud (Difference) ?		10scn 1rn alleles amyloidosis c57bl chemotaxis del deposit differently efficacious encoded equally familiar fever formyl fpr2 isoforms mediterranean mobilization modulating predominant preference robust saa1 selectivity tlr2 tlr4lps toll	arteriopathy autosomal cadasil cavitary confirms eif2b encountered entity excluded fifty frequencies heterogeneous increasingly infancy infarcts inherited leukoencephalopathies leukoencephalopathy magnetic matter onset oriented realized resonance subcortical symmetrical systematic underestimated white
Tagcloud (Intersection) ?