THPO

Gene Name		thrombopoietin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space
	Molecular Function	Cytokine Activity Hormone Activity Growth Factor Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Multicellular Organismal Development Blood Coagulation Cell Proliferation Myeloid Cell Differentiation Platelet Activation Thrombopoietin-mediated Signaling Pathway Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation)
Drugs
Diseases
GWAS		Platelet counts ( 22139419 20139978)
Protein-protein Interactions		4 interactors: APH1A EP300 MPL NUMBL
Entrez ID		7066
HPRD ID		02500
Ensembl ID		ENSG00000090534
Uniprot IDs		P40225 Q5FBX8
PDB IDs		1V7M 1V7N
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Histone H2B Acetylation Notch Signaling Pathway Cell Surface Receptor Signaling Pathway N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Neuroblast Division In Subventricular Zone Regulation Of Tubulin Deacetylation Apoptotic Signaling Pathway Positive Regulation By Host Of Viral Transcription Amyloid Precursor Protein Catabolic Process N-terminal Protein Amino Acid Acetylation Cytokine-mediated Signaling Pathway Forebrain Neuroblast Division Signal Transduction Axonogenesis Membrane Protein Intracellular Domain Proteolysis Regulation Of Cytokine Production Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Signaling Axon Development Nervous System Development Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Cell Communication Cell Morphogenesis Involved In Neuron Differentiation Lateral Ventricle Development Notch Receptor Processing Anatomical Structure Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Neuron Projection Morphogenesis Somatic Stem Cell Division N-terminal Protein Amino Acid Modification Regulation Of Cellular Response To Heat Response To Cytokine Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cell Morphogenesis Involved In Differentiation Cell Proliferation Interaction With Symbiont Membrane Protein Proteolysis Positive Regulation Of Dendrite Morphogenesis Cellular Response To Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Neuron Projection Development Stem Cell Division Ventricular System Development Cell Projection Morphogenesis Organ Development
Tagcloud ?		biphosphoglycerate bpgm congenital csf3r epo epor erythrocytosis erythropoietin exhibit gelsolin germline haemoglobin hereditary inheritance inherited mendelian mpl mutase mutational myeloproliferative neutrophilia oxygen pedigrees sensing syndromes thrombocytosis thrombopoietin uncovered v617f