THPO

Description		thrombopoietin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Signaling Receptor Binding Cytokine Activity Hormone Activity Growth Factor Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Megakaryocyte Differentiation Megakaryocyte Development Thrombopoietin-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Hematopoietic Stem Cell Proliferation
Pathways		Platelet Aggregation (Plug Formation)
Drugs
Diseases
GWAS		Cardiometabolic and hematological traits ( 27668658) Diisocyanate-induced asthma ( 25918132) Mean spheric corpuscular volume ( 32888494) Platelet count ( 20139978 22139419 27863252 29403010 32888494) Plateletcrit ( 27863252 32888494)
Interacting Genes		6 interacting genes: APH1A EP300 MPL NUMBL S100A6 S100P
Entrez ID		7066
HPRD ID		02500
Ensembl ID		ENSG00000090534
Uniprot IDs		A0A3B3ITS0 F8W6L1 P40225 Q5FBX8
PDB IDs		1V7M 1V7N 8G04
Enriched GO Terms of Interacting Partners?		Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Platelet Formation Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Positive Regulation Of Cell Development Histone Crotonyltransferase Activity Basophil Homeostasis Thrombopoietin Receptor Activity Calcium-dependent Protein Binding Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Positive Regulation Of Platelet Formation N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity Monocyte Homeostasis Eosinophil Homeostasis Neuroblast Division In Subventricular Zone Axonogenesis Negative Regulation Of Protein Oligomerization Regulation Of Cell Development L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Regulation Of Tubulin Deacetylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Thrombopoietin-mediated Signaling Pathway Gamma-secretase Complex Positive Regulation Of TORC2 Signaling Positive Regulation Of T-helper 17 Cell Lineage Commitment Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Pre-mRNA Intronic Binding Positive Regulation Of T-helper 17 Cell Differentiation Regulation Of Protein Deacetylation Cellular Response To L-leucine N-terminal Protein Amino Acid Acetylation Internal Protein Amino Acid Acetylation Response To Hypoxia Myeloid Cell Differentiation Peptidyl-lysine Acetylation
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