THPO and APH1A

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		THPO	APH1A
Gene Name		thrombopoietin	APH1A gamma secretase subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Membrane Golgi Cisterna Membrane
	Molecular Function	Cytokine Activity Hormone Activity Growth Factor Activity	Endopeptidase Activity Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Multicellular Organismal Development Blood Coagulation Cell Proliferation Myeloid Cell Differentiation Platelet Activation Thrombopoietin-mediated Signaling Pathway Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade	Metanephros Development Membrane Protein Ectodomain Proteolysis Notch Signaling Pathway Notch Receptor Processing Axon Guidance Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Apoptotic Signaling Pathway
Pathways		Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation)	Signaling by NOTCH1 HD Domain Mutants in Cancer Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Regulated proteolysis of p75NTR Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by NOTCH p75 NTR receptor-mediated signalling Signaling by ERBB4 NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 NRIF signals cell death from the nucleus Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS		Platelet counts ( 22139419 20139978)
Protein-Protein Interactions		4 interactors: APH1A EP300 MPL NUMBL	15 interactors: ATF4 BHLHE40 GLP1R GPATCH8 HES1 HIVEP1 KLF11 NCSTN PSEN1 PSEN2 PSENEN RBFOX2 THPO TLE1 TMED10
Entrez ID		7066	51107
HPRD ID		02500	06360
Ensembl ID		ENSG00000090534	ENSG00000117362
Uniprot IDs		P40225 Q5FBX8	B4DUG7 Q96BI3
PDB IDs		1V7M 1V7N
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Histone H2B Acetylation Notch Signaling Pathway Cell Surface Receptor Signaling Pathway N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Neuroblast Division In Subventricular Zone Regulation Of Tubulin Deacetylation Apoptotic Signaling Pathway Positive Regulation By Host Of Viral Transcription Amyloid Precursor Protein Catabolic Process N-terminal Protein Amino Acid Acetylation Cytokine-mediated Signaling Pathway Forebrain Neuroblast Division Signal Transduction Axonogenesis Membrane Protein Intracellular Domain Proteolysis Regulation Of Cytokine Production Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Signaling Axon Development Nervous System Development Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Cell Communication Cell Morphogenesis Involved In Neuron Differentiation Lateral Ventricle Development Notch Receptor Processing Anatomical Structure Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Neuron Projection Morphogenesis Somatic Stem Cell Division N-terminal Protein Amino Acid Modification Regulation Of Cellular Response To Heat Response To Cytokine Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cell Morphogenesis Involved In Differentiation Cell Proliferation Interaction With Symbiont Membrane Protein Proteolysis Positive Regulation Of Dendrite Morphogenesis Cellular Response To Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Neuron Projection Development Stem Cell Division Ventricular System Development Cell Projection Morphogenesis Organ Development	Amyloid Precursor Protein Catabolic Process Notch Signaling Pathway Amyloid Precursor Protein Metabolic Process Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Membrane Protein Proteolysis Beta-amyloid Metabolic Process Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Metabolic Process Positive Regulation Of Cell Death Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Thymus Development Neural Tube Patterning Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Protein Processing Negative Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Neuron Development Apoptotic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Death Programmed Cell Death Cell Morphogenesis Involved In Neuron Differentiation Cell Death Death Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Neuron Differentiation Response To Stimulus Response To Organic Substance Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cell Morphogenesis Involved In Differentiation Cellular Response To Organic Substance Locomotion Peptide Metabolic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Transcription From RNA Polymerase II Promoter Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Phosphorus Metabolic Process Dorsal/ventral Neural Tube Patterning Cellular Nitrogen Compound Metabolic Process Movement Of Cell Or Subcellular Component
Tagcloud ?		biphosphoglycerate bpgm congenital csf3r epo epor erythrocytosis erythropoietin exhibit gelsolin germline haemoglobin hereditary inheritance inherited mendelian mpl mutase mutational myeloproliferative neutrophilia oxygen pedigrees sensing syndromes thrombocytosis thrombopoietin uncovered v617f	aph1b belonging categorize clarify cleave consequently exclusive fall gamma heterogeneous histopathological implying intensively kaplan meier mutually nicastrin pen presenilin probability probable proteolytically secretase transmembrane treatable triple ubiquitously univariate
Tagcloud (Difference) ?		biphosphoglycerate bpgm congenital csf3r epo epor erythrocytosis erythropoietin exhibit gelsolin germline haemoglobin hereditary inheritance inherited mendelian mpl mutase mutational myeloproliferative neutrophilia oxygen pedigrees sensing syndromes thrombocytosis thrombopoietin uncovered v617f	aph1b belonging categorize clarify cleave consequently exclusive fall gamma heterogeneous histopathological implying intensively kaplan meier mutually nicastrin pen presenilin probability probable proteolytically secretase transmembrane treatable triple ubiquitously univariate
Tagcloud (Intersection) ?