THPO and MPL

Number of citations of the paper that reports this interaction (PubMedID 9766811)
0

Data Source:
HPRD (in vivo)

		THPO	MPL
Description		thrombopoietin	MPL proto-oncogene, thrombopoietin receptor
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Nuclear Membrane Neuronal Cell Body
	Molecular Function	Signaling Receptor Binding Cytokine Activity Hormone Activity Growth Factor Activity	Cytokine Receptor Activity Protein Binding Thrombopoietin Receptor Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Megakaryocyte Differentiation Megakaryocyte Development Thrombopoietin-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Hematopoietic Stem Cell Proliferation	Neutrophil Homeostasis Platelet Formation Monocyte Homeostasis Thrombopoietin-mediated Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Cellular Response To Hypoxia Positive Regulation Of Platelet Formation Eosinophil Homeostasis Basophil Homeostasis
Pathways		Platelet Aggregation (Plug Formation)	Platelet Aggregation (Plug Formation)
Drugs			Romiplostim SB-559448 Eltrombopag Thrombopoietin Avatrombopag Lusutrombopag
Diseases			Congenital amegakaryocytic thrombocytopenia (CAMT)
GWAS		Cardiometabolic and hematological traits ( 27668658) Diisocyanate-induced asthma ( 25918132) Mean spheric corpuscular volume ( 32888494) Platelet count ( 20139978 22139419 27863252 29403010 32888494) Plateletcrit ( 27863252 32888494)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Platelet count ( 32888494) Plateletcrit ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		6 interacting genes: APH1A EP300 MPL NUMBL S100A6 S100P	9 interacting genes: ANKRA2 ATXN2L IRS2 JAK2 PTPN11 SHC1 SOCS1 THPO YWHAQ
Entrez ID		7066	4352
HPRD ID		02500	01161
Ensembl ID		ENSG00000090534	ENSG00000117400
Uniprot IDs		A0A3B3ITS0 F8W6L1 P40225 Q5FBX8	P40238
PDB IDs		1V7M 1V7N 8G04	8G04
Enriched GO Terms of Interacting Partners?		Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Platelet Formation Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Positive Regulation Of Cell Development Histone Crotonyltransferase Activity Basophil Homeostasis Thrombopoietin Receptor Activity Calcium-dependent Protein Binding Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Positive Regulation Of Platelet Formation N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity Monocyte Homeostasis Eosinophil Homeostasis Neuroblast Division In Subventricular Zone Axonogenesis Negative Regulation Of Protein Oligomerization Regulation Of Cell Development L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Regulation Of Tubulin Deacetylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Thrombopoietin-mediated Signaling Pathway Gamma-secretase Complex Positive Regulation Of TORC2 Signaling Positive Regulation Of T-helper 17 Cell Lineage Commitment Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Pre-mRNA Intronic Binding Positive Regulation Of T-helper 17 Cell Differentiation Regulation Of Protein Deacetylation Cellular Response To L-leucine N-terminal Protein Amino Acid Acetylation Internal Protein Amino Acid Acetylation Response To Hypoxia Myeloid Cell Differentiation Peptidyl-lysine Acetylation	Insulin Receptor Binding Protein Kinase Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Thrombopoietin-mediated Signaling Pathway Myeloid Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptide Hormone Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Lymphocyte Activation Phosphatidylinositol 3-kinase Binding Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Positive Regulation Of Cell Activation Cytokine-mediated Signaling Pathway Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Hormone Secretion Megakaryocyte Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Insulin Secretion Neuron Projection Regeneration Hemopoiesis Regulation Of Lymphocyte Activation Positive Regulation Of ERK1 And ERK2 Cascade 14-3-3 Protein Binding Regulation Of Peptide Hormone Secretion Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of D-glucose Import Epithelial Cell Migration Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Lipid Transport Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of D-glucose Transmembrane Transport Phosphotyrosine Residue Binding Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Activation Regulation Of Hormone Secretion Regulation Of Protein Secretion Positive Regulation Of T Cell Activation Signal Transduction Regulation Of MAPK Cascade Regulation Of Leukocyte Proliferation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of D-glucose Import Histone H3Y41 Kinase Activity Nuclear Receptor-mediated Mineralocorticoid Signaling Pathway Positive Regulation Of Secretion By Cell
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