THPO and MPL

Number of citations of the paper that reports this interaction (PMID 9766811)
1

Data Source:
HPRD (in vivo)

		THPO	MPL
Gene Name		thrombopoietin	MPL proto-oncogene, thrombopoietin receptor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Cytokine Activity Hormone Activity Growth Factor Activity	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Multicellular Organismal Development Blood Coagulation Cell Proliferation Myeloid Cell Differentiation Platelet Activation Thrombopoietin-mediated Signaling Pathway Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade	Cell Surface Receptor Signaling Pathway Blood Coagulation Cell Proliferation Cytokine-mediated Signaling Pathway Platelet Activation Regulation Of Chemokine Production Homeostasis Of Number Of Cells
Pathways		Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation)	Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation)
Drugs
Diseases
GWAS		Platelet counts ( 22139419 20139978)
Protein-Protein Interactions		4 interactors: APH1A EP300 MPL NUMBL	9 interactors: ANKRA2 ATXN2L IRS2 JAK2 PTPN11 SHC1 SOCS1 THPO YWHAQ
Entrez ID		7066	4352
HPRD ID		02500	01161
Ensembl ID		ENSG00000090534	ENSG00000117400
Uniprot IDs		P40225 Q5FBX8	P40238
PDB IDs		1V7M 1V7N
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Histone H2B Acetylation Notch Signaling Pathway Cell Surface Receptor Signaling Pathway N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Neuroblast Division In Subventricular Zone Regulation Of Tubulin Deacetylation Apoptotic Signaling Pathway Positive Regulation By Host Of Viral Transcription Amyloid Precursor Protein Catabolic Process N-terminal Protein Amino Acid Acetylation Cytokine-mediated Signaling Pathway Forebrain Neuroblast Division Signal Transduction Axonogenesis Membrane Protein Intracellular Domain Proteolysis Regulation Of Cytokine Production Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Signaling Axon Development Nervous System Development Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Cell Communication Cell Morphogenesis Involved In Neuron Differentiation Lateral Ventricle Development Notch Receptor Processing Anatomical Structure Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Neuron Projection Morphogenesis Somatic Stem Cell Division N-terminal Protein Amino Acid Modification Regulation Of Cellular Response To Heat Response To Cytokine Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cell Morphogenesis Involved In Differentiation Cell Proliferation Interaction With Symbiont Membrane Protein Proteolysis Positive Regulation Of Dendrite Morphogenesis Cellular Response To Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Neuron Projection Development Stem Cell Division Ventricular System Development Cell Projection Morphogenesis Organ Development	Cellular Response To Peptide Hormone Stimulus Regulation Of Interferon-gamma-mediated Signaling Pathway Cellular Response To Peptide JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Growth Hormone Response To Peptide JAK-STAT Cascade Cellular Response To Hormone Stimulus Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Innate Immune Response Regulation Of Cytokine-mediated Signaling Pathway Response To Organonitrogen Compound Positive Regulation Of Hormone Secretion Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Response To Hormone Interferon-gamma-mediated Signaling Pathway Blood Coagulation Hemostasis Positive Regulation Of MAPK Cascade Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Signaling Cellular Response To Interferon-gamma Regulation Of Protein Phosphorylation Insulin Receptor Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Interferon-gamma Negative Regulation Of Lipid Transport Immune System Process Regulation Of Body Fluid Levels Cellular Response To Fibroblast Growth Factor Stimulus Cellular Response To Cytokine Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Signal Transduction Wound Healing Regulation Of Insulin Secretion
Tagcloud ?		biphosphoglycerate bpgm congenital csf3r epo epor erythrocytosis erythropoietin exhibit gelsolin germline haemoglobin hereditary inheritance inherited mendelian mpl mutase mutational myeloproliferative neutrophilia oxygen pedigrees sensing syndromes thrombocytosis thrombopoietin uncovered v617f	advances begun biology commitment correlate determination developmental dlk experimental flk gata genetic hematopoietic hoxb4 identify impact implicated loci major mapping numbers others recently regulators scl stem strategies strongly variety
Tagcloud (Difference) ?		biphosphoglycerate bpgm congenital csf3r epo epor erythrocytosis erythropoietin exhibit gelsolin germline haemoglobin hereditary inheritance inherited mendelian mutase mutational myeloproliferative neutrophilia oxygen pedigrees sensing syndromes thrombocytosis thrombopoietin uncovered v617f	advances begun biology commitment correlate determination developmental dlk experimental flk gata genetic hematopoietic hoxb4 identify impact implicated loci major mapping numbers others recently regulators scl stem strategies strongly variety
Tagcloud (Intersection) ?		mpl