S100A2 and S100B

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		S100A2	S100B
Gene Name		S100 calcium binding protein A2	S100 calcium binding protein B
Image
Gene Ontology Annotations	Cellular Component	Cellular_component	Ruffle Extracellular Region Extracellular Space Nucleus Cytoplasm Neuronal Cell Body Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Calcium Ion Binding Protein Binding Identical Protein Binding	Calcium Ion Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Tau Protein Binding Calcium-dependent Protein Binding RAGE Receptor Binding
	Biological Process	Endothelial Cell Migration	Axonogenesis Central Nervous System Development Learning Or Memory Memory Cell Proliferation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Neuronal Synaptic Plasticity Astrocyte Differentiation Response To Glucocorticoid Response To Methylmercury Long-term Synaptic Potentiation Cellular Response To Hypoxia Negative Regulation Of Skeletal Muscle Cell Differentiation
Pathways			Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Advanced glycosylation endproduct receptor signaling Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Signaling by ERBB4 MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Nuclear signaling by ERBB4 Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs			Olopatadine Calcium N-Formylmethionine (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide
Diseases
GWAS			Lymphocyte counts ( 22286170)
Protein-Protein Interactions		11 interactors: FKBP4 MDM2 PPID S100A1 S100B S100P STUB1 TP53 TPM1 TPM2 TPM3	27 interactors: AGER AHNAK ANXA6 CACYBP CALM1 CAPZA1 DES GFAP GUCY2D IMPA1 IQGAP1 MAPT MDM2 NDRG1 PGM1 S100A1 S100A11 S100A2 S100A4 S100A6 S100P SPG21 STK38 SUGT1 TNIP1 TP53 VAV1
Entrez ID		6273	6285
HPRD ID		01508	01505
Ensembl ID		ENSG00000196754
Uniprot IDs		P29034	P04271
PDB IDs		2RGI 4DUQ	1MQ1 1UWO 2H61 2PRU 3CZT 3D0Y 3D10 3HCM
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Cellular Response To UV Actin Filament-based Movement Cellular Response To Light Stimulus Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Cellular Response To Stress Response To UV Cellular Response To Radiation Response To Abiotic Stimulus Cellular Response To Oxidative Stress Muscle Contraction Regulation Of ATPase Activity Regulation Of Signal Transduction By P53 Class Mediator Muscle System Process Positive Regulation Of Transport DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Hypoxia Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Response To Antibiotic Positive Regulation Of Cellular Component Biogenesis Chaperone-mediated Protein Folding Regulation Of Protein Complex Assembly Response To Light Stimulus Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Steroid Hormone Receptor Complex Assembly Positive Regulation Of Heart Rate By Epinephrine Cellular Response To UV-C Cellular Response To Vitamin B1 Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Peptidyl-prolyl Isomerization Signal Transduction In Response To DNA Damage Response To Oxidative Stress Regulation Of Cell Cycle Arrest Mitotic DNA Damage Checkpoint Protein Complex Assembly Negative Regulation Of Macromitophagy Positive Regulation Of Voltage-gated Calcium Channel Activity	Regulation Of Voltage-gated Calcium Channel Activity Cellular Response To Light Stimulus Cellular Response To Radiation Cellular Response To Stimulus Response To Stimulus Signal Transduction Response To Metal Ion Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune System Process Signaling Regulation Of Cation Channel Activity Cell Communication DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Wounding Intracellular Signal Transduction Signal Transduction In Response To DNA Damage Immune Response-regulating Signaling Pathway Response To Inorganic Substance Glycogen Catabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Innate Immune Response Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Polysaccharide Catabolic Process Response To Calcium Ion Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of DNA Replication Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Rhodopsin Mediated Signaling Pathway Immune Response Response To Growth Factor Response To Light Stimulus Energy Reserve Metabolic Process Defense Response Regulation Of Ion Transmembrane Transporter Activity Rhodopsin Mediated Signaling Pathway Cellular Carbohydrate Catabolic Process Regulation Of Transmembrane Transporter Activity Nervous System Development Positive Regulation Of Cation Channel Activity Regulation Of Cellular Process Immune Response-regulating Cell Surface Receptor Signaling Pathway
Tagcloud ?		carcinogenesis concept conflicting correlate cytoplasm debated disagree distributed downregulated dual ef equally hountis indicative indicator location middle movement nsclc operable positivity precise published seem stages substantial unfavorable varies	accessory antigens areas brings cd11c cd40 cd83 cd86 continually cytological dcs dec endocytic initiate interdigitating invariant lymphoid maintains migrate migratory multilectin patch periphery peyer pick recirculate resident speculate uncharacterized
Tagcloud (Difference) ?		carcinogenesis concept conflicting correlate cytoplasm debated disagree distributed downregulated dual ef equally hountis indicative indicator location middle movement nsclc operable positivity precise published seem stages substantial unfavorable varies	accessory antigens areas brings cd11c cd40 cd83 cd86 continually cytological dcs dec endocytic initiate interdigitating invariant lymphoid maintains migrate migratory multilectin patch periphery peyer pick recirculate resident speculate uncharacterized
Tagcloud (Intersection) ?