RPS10 and PFN2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RPS10	PFN2
Gene Name		ribosomal protein S10	profilin 2
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Membrane Cytosolic Small Ribosomal Subunit Extracellular Vesicular Exosome	Cytoplasm Cytoskeleton Terminal Bouton Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Poly(A) RNA Binding	Adenyl-nucleotide Exchange Factor Activity Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis
Pathways		Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Axon guidance Signaling by Robo receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: APP DMPK DNMT3B DVL3 EED FBXO25 HAP1 HIP1 KAT7 PFN2 PTTG1 SYK TCF25 WIZ XRCC6	31 interactors: ACTB ACTG1 CCDC113 DDX11 DLST DNM1 EEF1A1 EVL FAM173A FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPT5 SGTA SNTA1 SYN1 TERF1 VASP WDR33
Entrez ID		6204	5217
HPRD ID		04697	01451
Ensembl ID		ENSG00000124614	ENSG00000070087
Uniprot IDs		P46783	G5E9Q6 P35080
PDB IDs		3J3A	1D1J
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Chromosome Organization Organelle Organization Gene Expression Regulation Of Vesicle-mediated Transport Positive Regulation Of Organelle Organization Regulation Of Exocytosis Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Positive Regulation Of Protein Modification Process Genetic Imprinting Regulation Of Cell Differentiation Transcription, DNA-templated Positive Regulation Of Histone Methylation RNA Metabolic Process Regulation Of Gene Expression, Epigenetic Regulation Of Catalytic Activity RNA Biosynthetic Process Positive Regulation Of Cell Cycle Process DNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Axon Cargo Transport Regulation Of Cellular Process Regulation Of Histone Methylation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Positive Regulation Of Cell Cycle Regulation Of Cellular Component Organization Regulation Of Neurogenesis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Platelet Degranulation Positive Regulation Of JUN Kinase Activity Positive Regulation Of Histone Modification	Ephrin Receptor Signaling Pathway Chemotaxis Axon Guidance Positive Regulation Of Cellular Component Biogenesis Axonogenesis Movement Of Cell Or Subcellular Component Axon Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Stress Fiber Assembly Locomotion Positive Regulation Of Cytoskeleton Organization Neuron Projection Morphogenesis Regulation Of Actin Filament-based Process Neuron Development Organelle Organization Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Response To External Stimulus Protein Homooligomerization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Signaling Neuron Differentiation Cell Projection Organization Neuron Projection Development Positive Regulation Of Protein Polymerization Cell Communication Regulation Of Neurotransmitter Levels Actin Cytoskeleton Organization Regulation Of Synaptic Vesicle Exocytosis Regulation Of Actin Cytoskeleton Organization Actin Filament-based Process Platelet Aggregation Neurotransmitter Transport Positive Regulation Of Protein Complex Assembly Regulation Of Synaptic Vesicle Transport Neural Plate Formation Regulation Of Vasoconstriction By Circulating Norepinephrine Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Microvillus Assembly Positive Regulation Of Organelle Organization Cellular Process Positive Regulation Of Stress Fiber Assembly Cellular Component Assembly Positive Regulation Of Actin Filament Bundle Assembly Protein Oligomerization Regulation Of Cellular Component Organization Cell Junction Assembly
Tagcloud ?		26t 2a aberrations anemia blackfan cgh congenital copy dba deletions diamond fourfold haploinsufficiency heterozygous hyperactivation hypoproliferative korean malformations predisposition reductions rpl11 rpl35a rpl5 rps17 rps19 rps24 rps26 supports variations	actn1 candidates clonogenic gap gy hcls1 integration integrin itgb5 junction junctions microarray microarrays nci overrepresented platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature
Tagcloud (Difference) ?		26t 2a aberrations anemia blackfan cgh congenital copy dba deletions diamond fourfold haploinsufficiency heterozygous hyperactivation hypoproliferative korean malformations predisposition reductions rpl11 rpl35a rpl5 rps17 rps19 rps24 rps26 supports variations	actn1 candidates clonogenic gap gy hcls1 integration integrin itgb5 junction junctions microarray microarrays nci overrepresented platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature
Tagcloud (Intersection) ?